Ras
Las proteínas Ras son pequeñas GTPasas que actúan como interruptores moleculares en la vía de señalización MAPK, controlando el crecimiento, la diferenciación y la supervivencia celular. Ras activado inicia una cascada de señalización que incluye Raf, MEK y ERK, lo que lleva a diversas respuestas celulares. Las mutaciones en los genes Ras son comunes en el cáncer, lo que convierte a Ras en un enfoque importante de la investigación oncológica. En CymitQuimica, ofrecemos una gama de moduladores de Ras para apoyar su investigación en biología del cáncer, transducción de señales y desarrollo terapéutico.
Productos de "Ras"
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K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Forma y color:SolidPeso molecular:513.78Ref: TM-T6556
1mg52,00€2mg74,00€5mg123,00€10mg183,00€25mg378,00€50mg547,00€100mg750,00€1mL*10mM (DMSO)183,00€KRAS G12C inhibitor 13
CAS:KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Fórmula:C40H46F3N7O4Pureza:98%Forma y color:SolidPeso molecular:745.83Pan-RAS-IN-7
CAS:Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Fórmula:C59H76N8O8Forma y color:SolidPeso molecular:1025.28Ketoconazole
CAS:Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Fórmula:C26H28Cl2N4O4Pureza:99.53% - 99.62%Forma y color:Crystals From 4-Methylpentanone SolidPeso molecular:531.43KRAS inhibitor-9
CAS:KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.Fórmula:C13H9ClN2S2Pureza:99.66%Forma y color:SolidPeso molecular:292.81Ref: TM-T8756
1mg60,00€2mg86,00€5mg119,00€10mg188,00€25mg354,00€50mg512,00€100mg655,00€1mL*10mM (DMSO)143,00€KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFórmula:C31H30F5N7O2Pureza:98%Forma y color:SolidPeso molecular:627.61KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Fórmula:C51H65F4N9O9S2Forma y color:SolidPeso molecular:1088.24SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Fórmula:C24H26F3N5OPureza:98%Forma y color:SolidPeso molecular:457.49Eicosapentaenoic Acid
CAS:Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.Fórmula:C20H30O2Pureza:96.20%Forma y color:LiquidPeso molecular:302.45Oncrasin-1
CAS:Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrationsFórmula:C16H12ClNOPureza:99.75%Forma y color:SolidPeso molecular:269.73(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Fórmula:C31H28N6O2Pureza:97.78%Forma y color:SoildPeso molecular:516.59MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46Ref: TM-T22106
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€CASIN
CAS:CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Fórmula:C20H22N2OPureza:100% - 99.86%Forma y color:SolidPeso molecular:306.4Ref: TM-T3971
1mg38,00€2mg49,00€5mg74,00€10mg120,00€25mg188,00€50mg283,00€100mg435,00€500mg938,00€1mL*10mM (DMSO)74,00€Sotorasib
CAS:Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Fórmula:C30H30F2N6O3Pureza:98% - 99.89%Forma y color:SolidPeso molecular:560.59Ref: TM-T8684
1g1.359,00€1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg225,00€50mg374,00€100mg459,00€500mg1.026,00€1mL*10mM (DMSO)87,00€CID-1067700
CAS:CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).Fórmula:C18H18N2O4S2Pureza:99.46%Forma y color:SolidPeso molecular:390.48Ref: TM-T7558
1mg35,00€2mg52,00€5mg74,00€10mg111,00€25mg188,00€50mg246,00€100mg319,00€1mL*10mM (DMSO)82,00€KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFórmula:C30H36FN5O4Pureza:98%Forma y color:SolidPeso molecular:549.64RBC10
CAS:RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-Fórmula:C24H25ClN2O2Pureza:98.38%Forma y color:SolidPeso molecular:408.92Ref: TM-T24706
1mg34,00€2mg52,00€5mg80,00€10mg116,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)86,00€Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45Antineoplaston A10
CAS:Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.Fórmula:C13H14N2O3Pureza:99.42%Forma y color:SolidPeso molecular:246.26Ref: TM-T7131
2mg47,00€5mg71,00€10mg108,00€25mg205,00€50mg311,00€100mg449,00€200mg628,00€1mL*10mM (DMSO)78,00€KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Fórmula:C53H68ClF2N9O8SForma y color:SolidPeso molecular:1064.68XMU-MP-9
CAS:XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.Fórmula:C19H13ClFN3OSForma y color:SolidPeso molecular:385.84KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Fórmula:C24H19ClF2N4O3Pureza:98%Forma y color:SolidPeso molecular:484.88MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Fórmula:C33H36N2O3Pureza:97.18%Forma y color:OilPeso molecular:508.65Ref: TM-T24437
1mg37,00€5mg97,00€10mg169,00€25mg291,00€50mg423,00€100mg562,00€500mg1.121,00€1mL*10mM (DMSO)108,00€EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Forma y color:SolidPeso molecular:581.47Ref: TM-T6483
1mg47,00€5mg92,00€10mg136,00€25mg259,00€50mg472,00€100mg677,00€200mg934,00€1mL*10mM (DMSO)107,00€(E/Z)-ZINC09659342
CAS:(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.Fórmula:C23H15F3N2O4Pureza:95.83%Forma y color:SolidPeso molecular:440.37Ref: TM-T9986
1mg66,00€5mg145,00€10mg221,00€25mg378,00€50mg533,00€100mg718,00€200mg938,00€1mL*10mM (DMSO)160,00€(Rac)-Antineoplaston A10
CAS:Antineoplaston A10 is the first identified human antineoplaston, naturally occurring with anti-proliferative properties.Fórmula:C13H14N2O3Pureza:98.41%Forma y color:SolidPeso molecular:246.26Ref: TM-T5379
1mg40,00€5mg88,00€10mg129,00€25mg210,00€50mg311,00€100mg449,00€200mg627,00€1mL*10mM (DMSO)95,00€AZD0022
CAS:AZD0022 is a selective and orally active KRAS G12D inhibitor that displays exposure-dependent pRSK inhibition in a GP2D xenograft model.Fórmula:C34H30F4N6OForma y color:SoildPeso molecular:614.64ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFórmula:C14H11BrO3Pureza:99.12%Forma y color:SolidPeso molecular:307.139Ref: TM-T21970
5mg65,00€10mg95,00€25mg140,00€50mg202,00€100mg303,00€500mg725,00€1mL*10mM (DMSO)71,00€MRTF-A-IN-2
MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Forma y color:Odour SolidKRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Fórmula:C32H39F6N7O5Pureza:98%Forma y color:SolidPeso molecular:715.69K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29Ref: TM-T5469
2mg46,00€5mg70,00€10mg101,00€25mg182,00€50mg284,00€100mg424,00€200mg588,00€1mL*10mM (DMSO)77,00€Rhosin hydrochloride
CAS:Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases.Cost-effective and quality-assured.Fórmula:C20H20Cl2N6OPureza:97.33% - 98.92%Forma y color:SolidPeso molecular:431.318Ref: TM-T16745
1mg159,00€2mg217,00€5mg329,00€10mg472,00€25mg753,00€50mg1.026,00€100mg1.378,00€1mL*10mM (DMSO)363,00€EHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Fórmula:C25H30N6OPureza:100% - 99.86%Forma y color:SolidPeso molecular:430.55Ref: TM-T2427
5mg48,00€10mg73,00€25mg127,00€50mg213,00€100mg334,00€200mg492,00€500mg787,00€1mL*10mM (DMSO)52,00€KRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Fórmula:C33H39ClF2N6O3Forma y color:SolidPeso molecular:641.15
