p38 MAPK
Las p38 MAPK son un subgrupo de MAPK que responden a señales de estrés y están involucradas en la regulación de la inflamación, la diferenciación celular, la apoptosis y la autofagia. La señalización de p38 MAPK es crucial en las respuestas inmunitarias y está implicada en varias enfermedades, incluidas las condiciones inflamatorias crónicas, el cáncer y los trastornos neurodegenerativos. En CymitQuimica, ofrecemos una gama completa de inhibidores y moduladores de p38 MAPK para apoyar su investigación en inflamación, respuesta al estrés y desarrollo terapéutico.
Productos de "p38 MAPK"
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Lucidenic acid D
CAS:Lucidenic acid D2 is a nartural product from G. lucidum AF.Fórmula:C29H38O8Pureza:98%Forma y color:SolidPeso molecular:514.61Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Fórmula:C27H30O14Pureza:98.11% - 98.87%Forma y color:SolidPeso molecular:578.52PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Fórmula:C22H19BrF2N2O3Pureza:97.79% - 97.90%Forma y color:SolidPeso molecular:477.3Ref: TM-T1974
1mg46,00€5mg94,00€10mg144,00€25mg255,00€50mg406,00€100mg628,00€500mg1.320,00€1mL*10mM (DMSO)97,00€Bisabolangelone
CAS:Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.Fórmula:C15H20O3Pureza:98.91%Forma y color:SolidPeso molecular:248.32Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Fórmula:C14H8O5Forma y color:SolidPeso molecular:256.213-Methyl Adenine
CAS:Applications 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)Fórmula:C6H7N5Forma y color:White SolidPeso molecular:149.15p38 Kinase inhibitor 7
CAS:p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Fórmula:C22H25FN6OForma y color:SolidPeso molecular:408.4725,6,7-TRIMETHOXYFLAVONE
CAS:5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.Fórmula:C18H16O5Pureza:99.05% - 99.11%Forma y color:SolidPeso molecular:312.322-Aminooctadecane-1,3,4-Triol
CAS:2-Aminooctadecane-1,3,4-Triol (Phytosphingosine) is a natural product.Fórmula:C18H39NO3Pureza:≥98%Forma y color:SolidPeso molecular:317.51p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:97.79%Forma y color:SolidPeso molecular:332.42SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64% - 99.64%Forma y color:SolidPeso molecular:328.69Ref: TM-T22115
5mg47,00€10mg74,00€25mg135,00€50mg188,00€100mg283,00€200mg411,00€1mL*10mM (DMSO)50,00€Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Fórmula:C30H48O5Pureza:96.91% - 99.97%Forma y color:SolidPeso molecular:488.7Samidin
CAS:Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.Fórmula:C21H22O7Pureza:98%Forma y color:SolidPeso molecular:386.4Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFórmula:C22H30O2Pureza:98%Forma y color:SolidPeso molecular:326.47CAL-101
CAS:Producto controladoApplications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor. References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);Fórmula:C22H18FN7OForma y color:Light BrownPeso molecular:415.40SSK1
CAS:SSK1 is a senescent cell-killing and β-galactosidase-targeting precursor compound that activates phosphorylation levels of p38 MAPK in senescent cells.Fórmula:C31H34F2N4O18Pureza:98.97% - 99.83%Forma y color:SolidPeso molecular:788.61SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Fórmula:C16H12FN3SPureza:98% - 99.68%Forma y color:SolidPeso molecular:297.35p38 MAPK-IN-1
CAS:p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.Fórmula:C21H14F2N2OPureza:98%Forma y color:SolidPeso molecular:348.35Esculin
CAS:Esculin (Aesculin) is a glucoside found in horse chestnuts.Fórmula:C15H16O9Pureza:99.46% - 99.83%Forma y color:Cream PowderPeso molecular:340.28BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Forma y color:SolidPeso molecular:442.95Ref: TM-T3462
1mg35,00€5mg71,00€10mg101,00€25mg170,00€50mg264,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)78,00€p38 MAPK Inhibitor
CAS:p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Fórmula:C20H13ClFN3OPureza:99.24%Forma y color:SolidPeso molecular:365.79Ref: TM-T36010
1mg96,00€5mg294,00€10mg459,00€25mg677,00€50mg929,00€100mg1.235,00€200mg1.681,00€500µg59,00€WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:98.98%Forma y color:SolidPeso molecular:528.61EO-1606
CAS:EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.Fórmula:C21H17ClFNOPureza:98.84% - 99.27%Forma y color:SolidPeso molecular:353.82R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Fórmula:C19H19ClF2N4O3Pureza:99.42%Forma y color:SolidPeso molecular:424.83TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Fórmula:C20H12F3N3Pureza:98.77% - 99.94%Forma y color:SolidPeso molecular:351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€TAK-715
CAS:TAK-715 is a p38 MAPK inhibitor for p38α.Fórmula:C24H21N3OSPureza:99.69%Forma y color:SolidPeso molecular:399.51Ref: TM-T6150
1mg40,00€2mg52,00€5mg87,00€10mg99,00€25mg170,00€50mg324,00€100mg507,00€1mL*10mM (DMSO)96,00€Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Fórmula:C20H15Cl3N2OS·HNO3Pureza:98.66%Forma y color:SolidPeso molecular:500.78Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFórmula:C27H30O15Pureza:96.96% - 98.17%Forma y color:SolidPeso molecular:594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Scio-323
CAS:Scio-323是一种可口服的 p38丝裂原活化蛋白(MAPK)激酶抑制剂。Fórmula:C27H30FN3O4Pureza:100.00%Forma y color:SolidPeso molecular:479.54Ref: TM-T68139
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)294,00€(-)-Bornyl acetate
CAS:L-(-)-Bornyl acetate, an enantiomer from hyssop oil, offers antifungal, skin-whitening, and antioxidant benefits, and reduces inflammation.Fórmula:C12H20O2Pureza:≥98%Forma y color:LiquidPeso molecular:196.29Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Fórmula:C23H17NO2Se2Forma y color:SolidPeso molecular:497.31FR 167653
CAS:FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Fórmula:C24H20FN5O6SPureza:98%Forma y color:SolidPeso molecular:525.51Esculin sesquihydrate
CAS:Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimentalFórmula:C15H16O9H2OPureza:98%Forma y color:SolidPeso molecular:367.31p38α inhibitor 5
CAS:The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Fórmula:C26H23BrF2N2O3Forma y color:SolidPeso molecular:529.37PF-03715455
CAS:PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.Fórmula:C35H34ClN7O3S2Pureza:98%Forma y color:SolidPeso molecular:700.27UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Forma y color:SolidPeso molecular:640.68UR13870
CAS:UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Fórmula:C24H16F2N4Pureza:100% - 98.92%Forma y color:SolidPeso molecular:398.41Quercetin
CAS:Producto controladoFórmula:C15H10O7Forma y color:Yellow Crystalline PowderPeso molecular:302.24AMG-548
CAS:AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.Fórmula:C29H27N5OPureza:98%Forma y color:SolidPeso molecular:461.56p38-α MAPK-IN-9
CAS:p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.Fórmula:C19H20N8O2Forma y color:SolidPeso molecular:392.414PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Fórmula:C27H26N6O2Pureza:98.04%Forma y color:SolidPeso molecular:466.53PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Forma y color:SolidPeso molecular:374.46Ref: TM-T16501
1mg37,00€5mg111,00€10mg202,00€25mg416,00€50mg620,00€100mg832,00€500mg1.663,00€1mL*10mM (DMSO)187,00€
