Raf
Las quinasas Raf son componentes clave de la vía de señalización MAPK/ERK, desempeñando un papel crítico en la transmisión de señales desde la membrana celular hasta el núcleo. La activación de Raf conduce a la fosforilación de MEK, que posteriormente activa ERK, influyendo en la división, diferenciación y supervivencia celular. Las mutaciones en Raf, particularmente en B-Raf, están asociadas con varios tipos de cáncer, lo que convierte a Raf en un objetivo crucial en la terapia contra el cáncer. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de Raf para apoyar su investigación en oncología, transducción de señales y desarrollo terapéutico.
Productos de "Raf"
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NVP-BAW2881
CAS:NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Fórmula:C22H15F3N4O2Pureza:98.19% - 99.97%Forma y color:SolidPeso molecular:424.38Ref: TM-T3641
1mg35,00€2mg50,00€5mg74,00€10mg115,00€25mg212,00€50mg343,00€100mg495,00€500mg1.111,00€1mL*10mM (DMSO)72,00€BRAFV600E-IN-1
BRAFV600E-IN-1 (compound 9S) is an inhibitor of BRAF. It exhibits significant apoptotic effects in cell lines expressing mutant KRAS and cancer cells harboring BRAFV600E.Fórmula:C23H16Cl3N5O4Forma y color:SolidPeso molecular:532.76LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Fórmula:C23H29FN6OPureza:96.96% - ≥95%Forma y color:SolidPeso molecular:424.51Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Fórmula:C23H20F3N5O2S2Pureza:100% - 99.83%Forma y color:SolidPeso molecular:519.56RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Fórmula:C28H29F3N4O4Pureza:99.43% - 99.83%Forma y color:SolidPeso molecular:542.55Ref: TM-T3711
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg259,00€50mg424,00€100mg625,00€500mg1.311,00€1mL*10mM (DMSO)94,00€CCT241161
CAS:CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.Fórmula:C28H27N7O3SPureza:100% - 98.48%Forma y color:SolidPeso molecular:541.62Zabofloxacin hydrochloride
CAS:Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.Fórmula:C19H21ClFN5O4Pureza:98%Forma y color:SolidPeso molecular:437.86Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Fórmula:C22H27ClFN7O4SPureza:98.64% - 99.74%Forma y color:SolidPeso molecular:540.01NVP-BHG712
CAS:NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src andFórmula:C26H20F3N7OPureza:97.32%Forma y color:SolidPeso molecular:503.48Ref: TM-T6348
1mg35,00€5mg79,00€10mg111,00€25mg212,00€50mg393,00€100mg587,00€200mg833,00€1mL*10mM (DMSO)88,00€I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Forma y color:SolidPeso molecular:482.92Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.13% - 98.3%Forma y color:SolidPeso molecular:471.46Ref: TM-T6971
1mg57,00€2mg82,00€5mg115,00€10mg172,00€25mg329,00€50mg527,00€100mg758,00€1mL*10mM (DMSO)118,00€IHMT-RAF-128
CAS:IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor models without causing significant toxicity.Fórmula:C27H24F3N5O2Forma y color:SolidPeso molecular:507.51
