CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Productos de "CFTR"
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UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂,可用于研究囊性纤维化。Fórmula:C14H8ClF3N2OPureza:100%Forma y color:SolidPeso molecular:312.67CFTR corrector 16
CAS:CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.Fórmula:C27H26ClN5O2SForma y color:SolidPeso molecular:520.05Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Fórmula:C24H18F2N2O5Pureza:99.48% - 99.68%Forma y color:SolidPeso molecular:452.41PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Fórmula:C28H29N3O2Pureza:99.87%Forma y color:SolidPeso molecular:439.55Ref: TM-T16516
1mg84,00€5mg215,00€10mg324,00€25mg520,00€50mg702,00€100mg950,00€200mg1.283,00€1mL*10mM (DMSO)210,00€Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Fórmula:C18H18N4O4Pureza:98.64%Forma y color:SolidPeso molecular:354.36Ref: TM-T16681
1mg96,00€5mg215,00€10mg378,00€25mg650,00€50mg927,00€100mg1.254,00€1mL*10mM (DMSO)236,00€Crinecerfont tosylate
CAS:Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).Fórmula:C34H36ClFN2O4S2Forma y color:SolidPeso molecular:655.242CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Fórmula:C29H27F2NO7Pureza:99.58%Forma y color:SolidPeso molecular:539.52Ref: TM-T63806
1mg52,00€5mg105,00€10mg164,00€25mg320,00€50mg504,00€100mg827,00€200mg1.111,00€1mL*10mM (DMSO)137,00€ARN23765
CAS:ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).Fórmula:C30H22F5N3O6Forma y color:SolidPeso molecular:615.504WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Fórmula:C21H23N3O5Pureza:98.76%Forma y color:SolidPeso molecular:397.42Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Fórmula:C24H28N2O3Pureza:99% - 99.98%Forma y color:SolidPeso molecular:392.49Ref: TM-T2588
1mg38,00€5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg455,00€500mg998,00€1mL*10mM (DMSO)88,00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Fórmula:C26H27F3N2O6Pureza:100% - 99.69%Forma y color:SolidPeso molecular:520.5Ref: TM-T2263
1mg40,00€2mg52,00€5mg82,00€10mg123,00€25mg212,00€50mg343,00€100mg505,00€1mL*10mM (DMSO)88,00€CFTR activator 2
CAS:CFTRactivator 2 (WAY-326769) acts as an activator for the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR).Fórmula:C27H27N3O3Forma y color:SolidPeso molecular:441.52KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFórmula:C19H17Cl2N3O2SPureza:98.86%Forma y color:SolidPeso molecular:422.33CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Fórmula:C29H27F2NO7Pureza:98.43%Forma y color:SolidPeso molecular:539.52Ref: TM-T10776
1mg74,00€5mg170,00€10mg264,00€25mg535,00€50mg753,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)202,00€CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Fórmula:C27H23FN4O4Pureza:99.66%Forma y color:SolidPeso molecular:486.49Ref: TM-T5312
2mg39,00€5mg58,00€10mg85,00€25mg156,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)63,00€SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Fórmula:C24H23N3O2Pureza:98.73%Forma y color:SolidPeso molecular:385.46Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Forma y color:SolidSRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Fórmula:C22H19N3O2Pureza:99.87%Forma y color:SolidPeso molecular:357.41PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Fórmula:C26H22N4O3Pureza:99.17% - ≥95%Forma y color:SolidPeso molecular:438.48Ref: TM-T1874
1mg40,00€2mg51,00€5mg85,00€10mg135,00€25mg269,00€50mg520,00€100mg745,00€1mL*10mM (DMSO)93,00€DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Fórmula:C14H8N2Na2O10S2Pureza:99.88%Forma y color:Physical Description White Powder (Ntp 1992)Peso molecular:474.33
