Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Productos de "Canal TRP / TRPV"
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M8-B Hydrochloride
CAS:M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.Fórmula:C22H25ClN2O3SPureza:99.33%Forma y color:SolidPeso molecular:432.96Ref: TM-T8442
2mg35,00€5mg52,00€10mg74,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)64,00€ML329
CAS:ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.Fórmula:C16H12N2O4SPureza:98.96%Forma y color:SolidPeso molecular:328.34Ref: TM-T4028
1mg52,00€2mg73,00€5mg115,00€10mg187,00€25mg424,00€50mg627,00€100mg893,00€1mL*10mM (DMSO)118,00€TRPM4-IN-1
CAS:TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Fórmula:C15H11Cl2NO4Pureza:97.22%Forma y color:SolidPeso molecular:340.16TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Fórmula:C13H12N2O4SPureza:99.25%Forma y color:SolidPeso molecular:292.31Ref: TM-T9709
1mg62,00€5mg135,00€10mg202,00€25mg335,00€50mg490,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)149,00€A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Fórmula:C22H20ClF2N3O2Forma y color:SolidPeso molecular:431.86ML204 hydrochloride
CAS:ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Fórmula:C15H19ClN2Forma y color:SolidPeso molecular:262.78HC-030031
CAS:HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Forma y color:SolidPeso molecular:355.39Optovin
CAS:Optovin is a TRPA1 activator, which is reversibly photoactivated.Fórmula:C15H13N3OS2Pureza:100.00% - 99.16%Forma y color:SolidPeso molecular:315.41Ref: TM-T6617
1mg40,00€2mg51,00€5mg81,00€10mg97,00€25mg188,00€50mg314,00€100mg563,00€200mg687,00€1mL*10mM (DMSO)86,00€TRPM4-IN-2
CAS:NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Fórmula:C19H14ClNO4Pureza:99.21%Forma y color:SolidPeso molecular:355.77(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Fórmula:C21H24N4OPureza:99.41% - 99.78%Forma y color:SoildPeso molecular:348.44Ref: TM-T29522L
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)162,00€PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Fórmula:C26H21FN2O3Pureza:99.82%Forma y color:SolidPeso molecular:428.45Ref: TM-T16483
1mg48,00€2mg65,00€5mg96,00€10mg160,00€25mg305,00€50mg472,00€100mg710,00€200mg938,00€500mg1.444,00€1mL*10mM (DMSO)96,00€Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Fórmula:C18H13F6N3O2SPureza:99.69% - 99.70%Forma y color:SolidPeso molecular:449.37IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Fórmula:C8H12INOPureza:99.76%Forma y color:SolidPeso molecular:265.09Ref: TM-T15543
1mg59,00€5mg126,00€10mg187,00€25mg264,00€50mg329,00€100mg455,00€1mL*10mM (DMSO)120,00€TRPC6-PAM-C20
CAS:TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Fórmula:C22H21NO4Pureza:98.16%Forma y color:SolidPeso molecular:363.41Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Fórmula:C16H11Cl3F3N3O3Pureza:99.47%Forma y color:SolidPeso molecular:456.63Ref: TM-T16687
1mg35,00€2mg52,00€5mg77,00€10mg97,00€25mg215,00€50mg363,00€100mg512,00€200mg738,00€500mg1.121,00€1mL*10mM (DMSO)86,00€RN-1734
CAS:RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.30%Forma y color:SolidPeso molecular:353.31SB-366791
CAS:SB-366791 is a new and selective cinnamide TRPV1 antagonist.Fórmula:C16H14ClNO2Pureza:99.12%Forma y color:SolidPeso molecular:287.74TRPM8 antagonist 2
CAS:TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Fórmula:C26H26N2O2Pureza:98.10%Forma y color:SolidPeso molecular:398.5Ref: TM-T5698
1mg35,00€5mg70,00€10mg104,00€25mg170,00€50mg274,00€100mg439,00€200mg632,00€1mL*10mM (DMSO)78,00€NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFórmula:C21H12F6N4Pureza:95.26%Forma y color:SolidPeso molecular:434.34Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Fórmula:C26H42ClN3O4Pureza:98.51% - 99.94%Forma y color:SolidPeso molecular:496.08HC-067047
CAS:HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .Fórmula:C26H28F3N3O2Pureza:99.45% - 99.79%Forma y color:SolidPeso molecular:471.51SAR7334
CAS:SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Fórmula:C21H22ClN3OPureza:99.62% - 99.71%Forma y color:SolidPeso molecular:367.87Ref: TM-T12849
1mg71,00€5mg160,00€10mg250,00€25mg401,00€50mg567,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)170,00€Asivatrep
CAS:Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Fórmula:C21H22F5N3O3SPureza:95.13%Forma y color:SolidPeso molecular:491.48WS-12
CAS:WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Fórmula:C18H27NO2Pureza:99.99%Forma y color:Whitish To White Solid CrystallinePeso molecular:289.41ABT-239
CAS:ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists.Fórmula:C22H22N2OPureza:100%Forma y color:SolidPeso molecular:330.42Ref: TM-T14087
1mg48,00€5mg96,00€10mg160,00€25mg313,00€50mg470,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)96,00€JNJ-28583113
CAS:JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Fórmula:C19H21F3N2O2Pureza:98.57%Forma y color:SolidPeso molecular:366.38Ref: TM-T74779
1mg92,00€5mg215,00€10mg321,00€25mg494,00€50mg856,00€100mg1.478,00€200mg1.931,00€1mL*10mM (DMSO)225,00€PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Fórmula:C27H32ClF3N2O2Pureza:97.91% - 99.3%Forma y color:SolidPeso molecular:509Ref: TM-T64337
1mg73,00€5mg145,00€10mg197,00€25mg333,00€50mg475,00€100mg655,00€200mg882,00€1mL*10mM (DMSO)163,00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Fórmula:C16H19NO3SPureza:99.46%Forma y color:SolidPeso molecular:305.39Ref: TM-T28118
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg255,00€100mg378,00€200mg533,00€1mL*10mM (DMSO)74,00€M084
CAS:M084 (N-Butyl-1H-benzimidazol-2-amine) is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.Fórmula:C11H15N3Pureza:98.13%Forma y color:SolidPeso molecular:189.26Ref: TM-T8607
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)145,00€MDR-652
CAS:MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFórmula:C22H23ClFN3O2SPureza:99.96%Forma y color:SolidPeso molecular:447.95Ref: TM-T22360
1mg66,00€5mg144,00€10mg205,00€25mg369,00€50mg558,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)157,00€BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Fórmula:C23H21F3N4O2Pureza:99.68%Forma y color:SolidPeso molecular:442.43Ref: TM-T10537
1mg133,00€2mg177,00€5mg274,00€10mg432,00€25mg630,00€50mg825,00€100mg1.103,00€500mg2.205,00€1mL*10mM (DMSO)301,00€AM12
CAS:AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Fórmula:C15H9BrO5Pureza:98%Forma y color:SolidPeso molecular:349.13BTD
CAS:BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Fórmula:C24H33N3O4SForma y color:SolidPeso molecular:459.6TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Fórmula:C11H17BrN2Pureza:97%Forma y color:SolidPeso molecular:257.17Ref: TM-T9776
5mg47,00€10mg65,00€25mg96,00€50mg180,00€100mg283,00€200mg424,00€500mg697,00€1mL*10mM (DMSO)50,00€AC1903
CAS:AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.Fórmula:C19H17N3OPureza:98.45%Forma y color:SolidPeso molecular:303.36Linoleoyl Ethanolamide
CAS:Linoleoyl Ethanolamide is an endocannabinoid agent.Fórmula:C20H37NO2Pureza:99.97%Forma y color:SolidPeso molecular:323.51Ref: TM-T8425
1mg35,00€5mg67,00€10mg90,00€25mg164,00€50mg239,00€100mg348,00€200mg522,00€1mL*10mM (DMSO)85,00€BCTC
CAS:BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)Fórmula:C20H25ClN4OPureza:99.21%Forma y color:SolidPeso molecular:372.89N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride
CAS:N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.Fórmula:C16H17ClN4Pureza:99.25%Forma y color:SolidPeso molecular:300.79Ref: TM-T8565
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Fórmula:C21H13ClF6N2O5SPureza:98% - 99.17%Forma y color:SolidPeso molecular:554.85cim0216
CAS:CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.Fórmula:C21H21N3O2Pureza:99.87%Forma y color:SolidPeso molecular:347.41Ref: TM-T9263
1mg47,00€2mg59,00€5mg92,00€10mg145,00€25mg298,00€50mg465,00€100mg702,00€500mg1.454,00€1mL*10mM (DMSO)92,00€AMG 517
CAS:AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1Fórmula:C20H13F3N4O2SPureza:99.77% - 99.85%Forma y color:SolidPeso molecular:430.4GSK2798745
CAS:GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).Fórmula:C25H28N6O3Forma y color:SolidPeso molecular:460.53MK6-83
CAS:MK6-83 is the transient receptor potential channel ML3 agonist.Fórmula:C16H20N2O2S2Pureza:99.71%Forma y color:SolidPeso molecular:336.47TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Fórmula:C25H22F2N4O2Pureza:99.79%Forma y color:SolidPeso molecular:448.46ABT 102
CAS:ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Fórmula:C21H24N4OPureza:98.38% - 99.72%Forma y color:SolidPeso molecular:348.44Ref: TM-T29522
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)259,00€(Z)-Capsaicin
CAS:(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer ofFórmula:C18H27NO3Pureza:97.33% - 99.67%Forma y color:SolidPeso molecular:305.41Resolvin D2
CAS:Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.Fórmula:C22H32O5Pureza:98%Forma y color:SolidPeso molecular:376.49JNJ-17203212
CAS:JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Fórmula:C17H15F6N5OPureza:99.18%Forma y color:SolidPeso molecular:419.32AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Fórmula:C11H12ClNOPureza:99.85% - 99.87%Forma y color:SolidPeso molecular:209.67Ref: TM-T21543
2mg35,00€5mg50,00€10mg73,00€25mg140,00€50mg215,00€100mg338,00€500mg723,00€1mL*10mM (DMSO)50,00€TRPM8 antagonist WS-3
CAS:TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).Fórmula:C13H25NOPureza:97.64%Forma y color:DrypowderPeso molecular:211.34
