Canal de cloruro
Los canales de cloruro son proteínas de membrana que controlan el movimiento de los iones de cloruro a través de las membranas celulares, desempeñando un papel vital en el mantenimiento del volumen celular, la excitabilidad eléctrica y el equilibrio ácido-base. La desregulación de los canales de cloruro está relacionada con enfermedades como la fibrosis quística, la epilepsia y los trastornos renales. En CymitQuimica, ofrecemos una variedad de moduladores de canales de cloruro para apoyar su investigación en el transporte de iones, la homeostasis celular y los mecanismos de enfermedades.
Productos de "Canal de cloruro"
Ordenar por
T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Fórmula:C19H20N4O3S2Pureza:97.18% - 98.15%Forma y color:SolidPeso molecular:416.52MONNA
CAS:MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Fórmula:C18H14N2O5Pureza:98.29%Forma y color:SolidPeso molecular:338.31CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Fórmula:C18H21NO4SPureza:99.92%Forma y color:SolidPeso molecular:347.43Picrotoxinin
CAS:Picrotoxinin blocks chloride channels, antagonizes GABAA noncompetitively (IC50: 1.15 μM, α1β2γ2L), and induces convulsions.Fórmula:C15H16O6Pureza:98.07%Forma y color:SolidPeso molecular:292.28Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Fórmula:C13H9F3N2O2Pureza:99.47%Forma y color:SolidPeso molecular:282.22Irisolidone
CAS:Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.Fórmula:C17H14O6Pureza:99.41% - 99.46%Forma y color:SolidPeso molecular:314.29Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Fórmula:C26H17ClF9N3O3Pureza:99.10% - 99.38%Forma y color:SolidPeso molecular:625.87NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.Fórmula:C15H11F3N2O3Pureza:99.62%Forma y color:SolidPeso molecular:324.25Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Fórmula:C24H32N2O4Pureza:99.13%Forma y color:SolidPeso molecular:412.52Ref: TM-T50082
1mg84,00€5mg167,00€10mg250,00€25mg414,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)187,00€Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.Fórmula:C22H24N2O5SPureza:97.01%Forma y color:SolidPeso molecular:428.5Ref: TM-T15192
1mg37,00€2mg50,00€5mg79,00€10mg126,00€25mg254,00€50mg429,00€100mg632,00€200mg899,00€1mL*10mM (DMSO)87,00€Talniflumate
CAS:Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cellFórmula:C21H13F3N2O4Pureza:98% - 99.81%Forma y color:White To Pale Yellow Crystalline PowderPeso molecular:414.33Ref: TM-T4503
1mg37,00€2mg52,00€5mg77,00€10mg97,00€25mg182,00€50mg300,00€100mg449,00€1mL*10mM (DMSO)85,00€Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Fórmula:C13H11NO2Pureza:99.60%Forma y color:White To Off-White Crystalline PowderPeso molecular:213.2319ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Fórmula:C19H19BrF2N2O2SForma y color:SolidPeso molecular:457.33Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Fórmula:C10H13NO4S2Pureza:99.16%Forma y color:SolidPeso molecular:275.34Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Fórmula:C14H10F3NO2Pureza:98.68%Forma y color:White To Light Yellow Crystalline PowderPeso molecular:281.23Shikonin
CAS:Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Fórmula:C16H16O5Pureza:98.13% - 99.9%Forma y color:SolidPeso molecular:288.3Ref: TM-T1125
5mg34,00€10mg52,00€25mg87,00€50mg140,00€100mg215,00€200mg319,00€500mg533,00€1mL*10mM (DMSO)52,00€DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFórmula:C22H28Cl2O4Pureza:99.79% - 99.87%Forma y color:SolidPeso molecular:427.36Ref: TM-T10979
1mg35,00€5mg74,00€10mg114,00€25mg235,00€50mg465,00€100mg605,00€200mg852,00€1mL*10mM (DMSO)84,00€Ani9
CAS:Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.Fórmula:C17H17ClN2O3Pureza:98.72%Forma y color:SolidPeso molecular:332.78Ref: TM-T26630
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg454,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)92,00€Picrotin
CAS:Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.Fórmula:C15H18O7Pureza:97.11%Forma y color:SolidPeso molecular:310.3ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Fórmula:C18H28N2O2SPureza:99.66%Forma y color:SolidPeso molecular:336.49
