P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Productos de "P-gp"
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Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Fórmula:C32H31F2N3O2Forma y color:SolidPeso molecular:527.6Evodine
CAS:1. Evodine has antinociceptive activity.Fórmula:C18H19NO5Pureza:98%Forma y color:SolidPeso molecular:329.35Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Fórmula:C19H18O8Pureza:97.43% - 98.53%Forma y color:SolidPeso molecular:374.34Ref: TM-TJS1159
1mg60,00€5mg127,00€10mg188,00€25mg348,00€50mg512,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)226,00€Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:100% - 99.55%Forma y color:SolidPeso molecular:636.99PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Fórmula:C26H23N3OPureza:98% - 98.53%Forma y color:SolidPeso molecular:393.48Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Fórmula:C21H21F2N3OSPureza:99.58%Forma y color:SolidPeso molecular:401.47Ref: TM-T13383
1mg96,00€5mg205,00€10mg309,00€25mg557,00€50mg838,00€100mg1.216,00€1mL*10mM (DMSO)221,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Forma y color:White To Yellowish Crystalline PowderPeso molecular:407.5Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Forma y color:SolidPeso molecular:294.42Ref: TM-T8596
1mg43,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)87,00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Fórmula:C43H52N4O5Pureza:98.54%Forma y color:SolidPeso molecular:704.9Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:98.74%Forma y color:SoildPeso molecular:698.73YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:97.50%Forma y color:SolidPeso molecular:663.6Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.17%Forma y color:SolidPeso molecular:646.73Larotaxel
CAS:Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in breast and bladder cancer.Fórmula:C45H53NO14Pureza:99.22%Forma y color:SolidPeso molecular:831.9Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Fórmula:C39H40N6O10SPureza:99.84%Forma y color:SolidPeso molecular:784.83Ref: TM-T11578L
2mg42,00€5mg62,00€10mg88,00€25mg155,00€50mg250,00€100mg393,00€500mg893,00€1mL*10mM (DMSO)74,00€Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Forma y color:White To Off-White PowderPeso molecular:491.06Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Fórmula:C38H52N6O7Pureza:98% - 99.95%Forma y color:Crystalline SolidPeso molecular:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Forma y color:SolidPeso molecular:802.93Ref: TM-T0100
5mg47,00€10mg62,00€25mg95,00€50mg120,00€100mg180,00€200mg264,00€500mg449,00€1mL*10mM (DMSO)52,00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.85%Forma y color:White Or Light-Tan SolidPeso molecular:310.37Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Forma y color:SolidPeso molecular:769.96ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Fórmula:C32H38N4OPureza:98.86%Forma y color:SolidPeso molecular:494.67
