PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Productos de "PDE"
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Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Forma y color:SolidPeso molecular:405.8Ref: TM-T10590
1mg70,00€5mg135,00€10mg245,00€25mg409,00€50mg562,00€100mg780,00€200mg1.026,00€1mL*10mM (DMSO)149,00€Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.04%Forma y color:SolidPeso molecular:446.44Ref: TM-T27172
1mg69,00€5mg149,00€10mg235,00€25mg469,00€50mg753,00€100mg1.216,00€1mL*10mM (DMSO)164,00€Vardenafil hydrochloride
CAS:Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With DiabetesFórmula:C23H33ClN6O4SPureza:99.76% - 99.86%Forma y color:White To Off-White Cyrstalline SolidPeso molecular:525.06TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:98.48%Forma y color:SolidPeso molecular:460.45Ref: TM-T13189
1mg92,00€2mg120,00€5mg187,00€10mg279,00€25mg487,00€50mg705,00€100mg998,00€500mg1.882,00€1mL*10mM (DMSO)188,00€Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:98.3%Forma y color:SolidPeso molecular:687.54PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:100%Forma y color:SolidPeso molecular:318.4K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Fórmula:C14H13N3O2SPureza:99.12%Forma y color:SolidPeso molecular:287.34Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Fórmula:C20H27N5O2Pureza:99.58% - 99.90%Forma y color:Off-White SolidPeso molecular:369.46Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.11%Forma y color:SolidPeso molecular:253.3EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:98% - 99.38%Forma y color:SolidPeso molecular:425.5MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.29%Forma y color:SolidPeso molecular:422.44Anagrelide hydrochloride
CAS:Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.Fórmula:C10H7Cl2N3O·HClPureza:99.58%Forma y color:Off-White PowderPeso molecular:292.55Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:98.11%Forma y color:SolidPeso molecular:516.3Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Forma y color:Odour LiquidTAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Forma y color:SolidPeso molecular:458.36Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Forma y color:SolidPeso molecular:251.05Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:98.84%Forma y color:SolidPeso molecular:482.33Ref: TM-T63190
1mg77,00€5mg170,00€10mg248,00€25mg444,00€50mg662,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)170,00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Fórmula:C14H18N2OPureza:99.34% - 99.94%Forma y color:White SolidPeso molecular:230.31Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:100%Forma y color:SoildPeso molecular:403.88Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Forma y color:SolidPeso molecular:570.68Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:99.55% - 99.65%Forma y color:SolidPeso molecular:419.21Ref: TM-T4462
1mg35,00€2mg52,00€5mg74,00€10mg99,00€25mg170,00€50mg274,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)69,00€PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Forma y color:SolidPeso molecular:461.912-(Hydroxymethyl)pyridine
CAS:2-(Hydroxymethyl)pyridine (Piconol) is an intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.Fórmula:C6H7NOPureza:99.79%Forma y color:Clear Light Yellow To Orange Liquid LiquidPeso molecular:109.13Zaprinast
CAS:Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist.Fórmula:C13H13N5O2Pureza:99.73% - 99.77%Forma y color:White To Off White PowderPeso molecular:271.27Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Fórmula:C20H26N2O3Pureza:98.87%Forma y color:White To Off-White SolidPeso molecular:342.43Irsogladine
CAS:Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.Fórmula:C9H7Cl2N5Pureza:99.74% - 99.91%Forma y color:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecular:256.09uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Fórmula:C26H24F3N3O4Pureza:99.90%Forma y color:SolidPeso molecular:499.48Ref: TM-T67815
1mg159,00€5mg380,00€10mg570,00€25mg912,00€50mg1.216,00€100mg1.663,00€500mg3.315,00€1mL*10mM (DMSO)470,00€AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Fórmula:C22H14Cl2FN3O3Pureza:99.55% - 99.95%Forma y color:SolidPeso molecular:458.27Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFórmula:C19H31N7O4Pureza:99.42% - 99.51%Forma y color:SolidPeso molecular:421.49Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Forma y color:SolidPeso molecular:683.71MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Fórmula:C16H12ClN3O2Pureza:99.45%Forma y color:SolidPeso molecular:313.74Ref: TM-T21965
5mg47,00€10mg80,00€25mg145,00€50mg233,00€100mg335,00€200mg467,00€1mL*10mM (DMSO)49,00€Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Fórmula:C18H21N5SPureza:99.94%Forma y color:SolidPeso molecular:339.46Mirodenafil
CAS:Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Fórmula:C26H37N5O5SPureza:99.89%Forma y color:SolidPeso molecular:531.67Ref: TM-T16079
2mg35,00€5mg52,00€10mg79,00€25mg134,00€50mg210,00€100mg338,00€200mg497,00€1mL*10mM (DMSO)60,00€ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Fórmula:C27H28FN3O3Pureza:97.05%Forma y color:SolidPeso molecular:461.53Ref: TM-T38759
1mg156,00€5mg368,00€10mg509,00€25mg770,00€50mg1.035,00€100mg1.396,00€200mg1.882,00€1mL*10mM (DMSO)409,00€Dipyridamole
CAS:Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.Fórmula:C24H40N8O4Pureza:99.47% - 99.84%Forma y color:SolidPeso molecular:504.63Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:98.28%Forma y color:SolidPeso molecular:463.29Ref: TM-T11533
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg298,00€50mg487,00€100mg692,00€1mL*10mM (DMSO)106,00€Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Forma y color:SolidPeso molecular:334.37Ref: TM-T1708
2mg38,00€5mg60,00€10mg87,00€25mg162,00€50mg274,00€100mg406,00€500mg920,00€1mL*10mM (DMSO)66,00€Sulmazole
CAS:Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Fórmula:C14H13N3O2SPureza:99.64%Forma y color:SolidPeso molecular:287.34D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Fórmula:C21H19ClN2O2Pureza:97.57%Forma y color:SolidPeso molecular:366.84Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:97.28%Forma y color:SolidPeso molecular:360.41Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Fórmula:C28H31F6NO3Forma y color:SolidPeso molecular:543.54Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34Ref: TM-T8515
1mg38,00€2mg50,00€5mg81,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€200mg748,00€1mL*10mM (DMSO)89,00€PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:98.57%Forma y color:SolidPeso molecular:386.88Ref: TM-T10201
1mg341,00€5mg723,00€10mg969,00€25mg1.454,00€50mg1.948,00€100mg2.632,00€1mL*10mM (DMSO)815,00€ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Forma y color:Lyophilized PowderPeso molecular:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Forma y color:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Forma y color:SolidPeso molecular:375.34Ref: TM-T9239
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)187,00€ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.23%Forma y color:SolidPeso molecular:474.87Ref: TM-T10409
1mg64,00€5mg140,00€10mg219,00€25mg373,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)145,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Forma y color:SolidPeso molecular:322.77IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFórmula:C10H14N4O2Pureza:100% - 99.99%Forma y color:Off-WhitePeso molecular:222.24GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.52% - 99.66%Forma y color:SolidPeso molecular:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:100%Forma y color:SolidPeso molecular:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Forma y color:SolidPeso molecular:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84Ref: TM-T28352
1mg39,00€5mg73,00€10mg94,00€25mg153,00€50mg219,00€100mg325,00€200mg465,00€1mL*10mM (DMSO)84,00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:100% - 99.61%Forma y color:SolidPeso molecular:278.31Ref: TM-T23638
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mgA consultar1mL*10mM (DMSO)240,00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:100%Forma y color:SolidPeso molecular:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Forma y color:SolidPeso molecular:472.49Ref: TM-T3987
1mg34,00€2mg47,00€5mg70,00€10mg96,00€25mg170,00€50mg298,00€100mg430,00€200mg607,00€1mL*10mM (DMSO)71,00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:100% - ≥95%Forma y color:SolidPeso molecular:463.29Ref: TM-T2646
2mg39,00€5mg57,00€10mg93,00€25mg145,00€50mg235,00€100mg351,00€200mg528,00€1mL*10mM (DMSO)58,00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Fórmula:C9H13N5OPureza:99.02%Forma y color:White SolidPeso molecular:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.37%Forma y color:SolidPeso molecular:387.88Ref: TM-T36832
1mg37,00€5mg79,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Fórmula:C24H19BFNO5SPureza:98.92%Forma y color:SolidPeso molecular:463.29PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Fórmula:C20H25N7O2Pureza:99.11% - 99.11%Forma y color:SolidPeso molecular:395.46Naproxen etemesil
CAS:Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.Fórmula:C17H20O5SPureza:98%Forma y color:SolidPeso molecular:336.4CRT0273750
CAS:CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.Fórmula:C25H22ClF3N4O2Pureza:99.49%Forma y color:SolidPeso molecular:502.92Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Fórmula:C11H10ClN3OPureza:99.21% - 99.67%Forma y color:SolidPeso molecular:235.67Ref: TM-T9871
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg475,00€100mg638,00€200mg845,00€1mL*10mM (DMSO)138,00€BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.03%Forma y color:SolidPeso molecular:543.54Ref: TM-T10545
1mg221,00€5mg550,00€10mg905,00€25mg1.890,00€50mg3.030,00€100mg4.874,00€1mL*10mM (DMSO)35,00€Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Fórmula:C12H9N3OPureza:99.22% - 99.92%Forma y color:SolidPeso molecular:211.22
