Receptor de retinoides
Los receptores de retinoides son receptores nucleares que median los efectos de los retinoides (derivados de la vitamina A) sobre la expresión génica. Estos receptores juegan un papel vital en la diferenciación celular, la proliferación y la apoptosis. Los inhibidores de los receptores de retinoides se utilizan para estudiar su implicación en diversas enfermedades, incluyendo el cáncer, los trastornos cutáneos y las condiciones metabólicas. Al modular la actividad de los receptores de retinoides, estos inhibidores pueden proporcionar información sobre los mecanismos de señalización de los retinoides y su potencial terapéutico. En CymitQuimica, ofrecemos inhibidores de los receptores de retinoides para apoyar su investigación en dermatología, oncología y regulación metabólica.
Productos de "Receptor de retinoides"
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Bexarotene
CAS:Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).Fórmula:C24H28O2Pureza:99% - 99.65%Forma y color:White SolidPeso molecular:348.48Tarenflurbil
CAS:Tarenflurbil, the R-enantiomer of flurbiprofen, lacks COX inhibition and was tested for Alzheimer's treatment.Fórmula:C15H13FO2Pureza:100% - 98%Forma y color:SolidPeso molecular:244.26LY 178002
CAS:LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.Fórmula:C18H25NO2SPureza:98%Forma y color:SolidPeso molecular:319.46LG100268
CAS:LG100268 is a selective, and oral RXR agonist,inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.Fórmula:C24H29NO2Pureza:99.83%Forma y color:SolidPeso molecular:363.49LG-100064
CAS:LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)Fórmula:C23H26O3Pureza:98.65%Forma y color:SolidPeso molecular:350.45Ref: TM-T11844
2mg47,00€5mg70,00€10mg97,00€25mg167,00€50mg249,00€100mg369,00€200mg545,00€1mL*10mM (DMSO)77,00€CD2665
CAS:CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.Fórmula:C31H34O5Pureza:99.67%Forma y color:SolidPeso molecular:486.6trifarotene
CAS:Trifarotene (CD5789) is a RARγ agonist, 65x more selective than RARα and 16x than RARβ, with EC50 of 7.7 nM.Fórmula:C29H33NO4Pureza:99.78%Forma y color:SolidPeso molecular:459.58AC-55649
CAS:AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.Fórmula:C21H26O2Pureza:99.84%Forma y color:SolidPeso molecular:310.43ER 50891
CAS:ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.Fórmula:C29H24N2O2Pureza:99.49%Forma y color:SolidPeso molecular:432.51HX 531
CAS:HX 531 is a RXR antagonist (IC50 of 18 nM).Cost-effective and quality-assured.Fórmula:C29H29N3O4Pureza:98.59% - 99.43%Forma y color:SolidPeso molecular:483.56MM 11253
CAS:MM 11253 is a RARγ antagonist with IC50 of 44nM.Fórmula:C28H30O2S2Pureza:98.62%Forma y color:SolidPeso molecular:462.67BMS 753
CAS:BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).Fórmula:C21H21NO4Pureza:98.4%Forma y color:SolidPeso molecular:351.4Fluorobexarotene
CAS:Fluorobexarotene, a potent RXR agonist, has 75% higher affinity than Bexarotene with Ki of 12 nM and EC50 of 43 nM for RXRα.Fórmula:C24H27FO2Pureza:99.23%Forma y color:SolidPeso molecular:366.47Ref: TM-T11303
1mg173,00€5mg439,00€10mg648,00€25mg1.017,00€50mg1.378,00€100mg1.853,00€500mg3.695,00€1mL*10mM (DMSO)354,00€Tazarotene
CAS:Tazarotene (Zorac), a synthetic topical retinoid, treats psoriasis by normalizing keratinocytes and reducing growth.Fórmula:C21H21NO2SPureza:97.01% - 99.14%Forma y color:White SolidPeso molecular:351.46Ref: TM-T6696
5mg38,00€10mg49,00€25mg88,00€50mg147,00€100mg256,00€200mg334,00€500mg563,00€1mL*10mM (DMSO)55,00€AGN 196996
CAS:AGN 196996: strong RARα inhibitor (Ki: 2 nM), weak for RARβ/γ (Ki: 1087/8523 nM).Fórmula:C24H20BrNO5Pureza:≥98%Forma y color:SolidPeso molecular:482.32Ref: TM-T10261
1mg59,00€5mg131,00€10mg190,00€25mg329,00€50mg477,00€100mg702,00€1mL*10mM (DMSO)138,00€Ch55
CAS:Ch55, a potent HL60 cell differentiator (EC50=200nM), binds well to RAR-α/β, useful for cancer research.Fórmula:C24H28O3Pureza:99.01%Forma y color:SolidPeso molecular:364.48Ref: TM-T14946
1mg43,00€5mg90,00€10mg130,00€25mg264,00€50mg414,00€100mg645,00€200mg895,00€1mL*10mM (DMSO)88,00€Isotretinoin
CAS:Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promoteFórmula:C20H28O2Pureza:98.06% - 99.61%Forma y color:Reddish-Orange Plates From Isopropyl Alcohol (Ntp 1992)Peso molecular:300.44BMS453
CAS:BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin.Fórmula:C27H24O2Pureza:99.78%Forma y color:SolidPeso molecular:380.48UVI 3003
CAS:UVI 3003 blocks retinoid X receptor (RXRα) in Xenopus/human Cos7 cells; IC50: 0.22/0.24 μM.Fórmula:C28H36O4Pureza:99.82%Forma y color:SolidPeso molecular:436.58Ref: TM-T17209
1mg35,00€2mg52,00€5mg74,00€10mg119,00€25mg243,00€50mg406,00€100mg607,00€1mL*10mM (DMSO)86,00€K-8012
CAS:K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.Fórmula:C23H23FN4Pureza:98.24%Forma y color:SolidPeso molecular:374.45Ref: TM-T24240
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.157,00€1mL*10mM (DMSO)266,00€
