P450
Las enzimas Citocromo P450 son una gran familia de enzimas involucradas en el metabolismo de diversos compuestos endógenos y exógenos, incluidos medicamentos, toxinas y hormonas. Los inhibidores del P450 se utilizan ampliamente para estudiar el metabolismo de fármacos, la farmacocinética y el papel de estas enzimas en estados patológicos como el cáncer y los trastornos hepáticos. En CymitQuimica, ofrecemos una amplia selección de inhibidores del P450 para apoyar su investigación en farmacología, toxicología y regulación metabólica.
Productos de "P450"
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BI 653048 phosphate
CAS:BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).Fórmula:C23H28F4N3O8PSPureza:98%Forma y color:SolidPeso molecular:613.52Canadine
CAS:Canadine has antioxidant activity with low-toxic effect.Fórmula:C20H21NO4Pureza:98%Forma y color:SolidPeso molecular:339.39Licopyranocoumarin
CAS:Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrialFórmula:C21H20O7Pureza:98%Forma y color:SolidPeso molecular:384.38BMS-819881
CAS:BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent forFórmula:C24H21ClN2O4SPureza:98%Forma y color:SolidPeso molecular:468.95Uniconazole
CAS:Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM).Fórmula:C15H18ClN3OPureza:99.94%Forma y color:White-Light Brown CrystallinePeso molecular:291.78BI 653048
CAS:BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.Fórmula:C23H25F4N3O4SPureza:98%Forma y color:SolidPeso molecular:515.52Casopitant mesylate
CAS:Casopitant mesylate (GW679769B): Selective, brain-permeable NK1 receptor blocker, oral antiemetic.Fórmula:C31H39F7N4O5SPureza:98%Forma y color:SolidPeso molecular:712.721-Ethynylpyrene
CAS:1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).Fórmula:C18H10Pureza:98.89%Forma y color:SolidPeso molecular:226.272,3',4,6-Tetrahydroxybenzophenone
CAS:2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.Fórmula:C13H10O5Forma y color:SolidPeso molecular:246.22Humantenirine
CAS:Humantenirine is a natural product of Gelsemium, Loganiaceae.Fórmula:C21H26N2O4Pureza:98%Forma y color:SolidPeso molecular:370.44CRTH2-IN-1
CAS:CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.Fórmula:C21H21FN2O4SPureza:98%Forma y color:SolidPeso molecular:416.47(S)-Mephenytoin
CAS:(S)-Mephenytoin: (+)-enantiomer, anticonvulsant, CYP2C19 substrate for analyzing CYP450 metabolism.Fórmula:C12H14N2O2Pureza:99.05% - 99.82%Forma y color:SolidPeso molecular:218.25Ref: TM-T21529
1mg56,00€5mg119,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€1mL*10mM (DMSO)131,00€Norfluoxetine Hydrochloride
CAS:Norfluoxetine Hydrochloride (Norfluoxetine HCl) is an active metabolite of fluoxetine. Fluoxetine is an antidepressant drug.Fórmula:C16H17ClF3NOPureza:99.75%Forma y color:SolidPeso molecular:331.76Ref: TM-T21029
1mg48,00€5mg135,00€10mg205,00€25mg369,00€50mg502,00€100mg727,00€200mg1.017,00€1mL*10mM (DMSO)99,00€GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Fórmula:C24H16Cl2F2N6OPureza:98.59%Forma y color:SolidPeso molecular:513.33Ref: TM-T4488
1mg47,00€2mg59,00€5mg92,00€10mg117,00€25mg172,00€50mg271,00€100mg454,00€1mL*10mM (DMSO)95,00€Climbazole
CAS:Climbazole (BAY-e 6975) is a broad-spectrum imidazole antifungal agent with anti-dandruff benefits.Fórmula:C15H17ClN2O2Pureza:98.23%Forma y color:White Solid CrystallinePeso molecular:292.76Methysticin
CAS:Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.Fórmula:C15H14O5Pureza:98%Forma y color:SolidPeso molecular:274.27Cephaeline dihydrochloride
CAS:(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).Fórmula:C28H40Cl2N2O4Forma y color:SolidPeso molecular:539.546',7'-Dihydroxybergamottin
CAS:6',7'-Dihydroxybergamottin (DHB) inhibits CYP3A4 and POR; affects nifedipine oxidation.Fórmula:C21H24O6Pureza:98%Forma y color:SolidPeso molecular:372.41Dipterocarpol
CAS:Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng.Fórmula:C30H50O2Pureza:98%Forma y color:SolidPeso molecular:442.7282-Hydroxy-1-Methoxyaporphine
CAS:2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.Fórmula:C18H19NO2Pureza:98%Forma y color:SolidPeso molecular:281.355
