HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Productos de "HIF / HIF Prolilhidroxilasa"
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Hay 96 productos en esta categoría.
TC-S 7009
CAS:TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Fórmula:C12H6ClFN4O3Pureza:100% - 99.71%Forma y color:SolidPeso molecular:308.65PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFórmula:C26H27N7O4Pureza:98%Forma y color:SolidPeso molecular:501.54Tilorone dihydrochloride
CAS:Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Fórmula:C25H36Cl2N2O3Pureza:98% - 99.86%Forma y color:Orange Yellow Crystal PowderPeso molecular:483.47SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Fórmula:C18H16O3SPureza:98.31%Forma y color:SolidPeso molecular:312.38Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Fórmula:C17H16N4O4Pureza:99.14% - 99.61%Forma y color:SolidPeso molecular:340.33Ref: TM-T15219
1mg39,00€2mg50,00€5mg79,00€10mg115,00€25mg188,00€50mg311,00€100mg462,00€1mL*10mM (DMSO)90,00€HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFórmula:C12H13F5O4S2Pureza:98%Forma y color:SolidPeso molecular:380.35GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Fórmula:C18H15N3O2Pureza:98.20%Forma y color:SolidPeso molecular:305.33Ref: TM-T15396
1mg70,00€5mg135,00€10mg188,00€25mg325,00€50mg465,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)149,00€2,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Fórmula:C11H13NO4Pureza:99.74%Forma y color:Yellow Solid CrystallinePeso molecular:223.23Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Fórmula:C9H10O4Pureza:99.88%Forma y color:White Crystal Or PowderPeso molecular:182.17ZK-261991
CAS:ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Fórmula:C24H25N7O2Pureza:98%Forma y color:SolidPeso molecular:443.5Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Fórmula:C16H16N2O6Pureza:98%Forma y color:SolidPeso molecular:332.31Ref: TM-T5176
1mg35,00€2mg52,00€5mg94,00€10mg167,00€25mg300,00€50mg516,00€100mg732,00€1ml*10 (DMSO)112,00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Fórmula:C17H12F3NO4SPureza:99.34% - 99.41%Forma y color:SolidPeso molecular:383.34Ref: TM-T16679
1mg70,00€5mg153,00€10mg216,00€25mg411,00€50mg660,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)166,00€DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Fórmula:C17H13ClN2O5Forma y color:SolidPeso molecular:360.749HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Fórmula:C18H19IN2O2Pureza:99.17%Forma y color:SolidPeso molecular:422.26Ref: TM-T67767
1mg48,00€5mg96,00€10mg157,00€25mg281,00€50mg454,00€100mg702,00€200mg938,00€1mL*10mM (DMSO)116,00€IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFórmula:C6H13Li3O11Pureza:≥95%Forma y color:White Crystalline PowderPeso molecular:281.98IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Fórmula:C15H13N3O2SPureza:99.74%Forma y color:White To Yellowish PowderPeso molecular:299.35Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Fórmula:C22H28ClN3O4Pureza:99.95%Forma y color:SolidPeso molecular:433.93Ref: TM-T64336
5mg46,00€10mg64,00€25mg109,00€50mg170,00€100mg273,00€200mg399,00€1mL*10mM (DMSO)49,00€HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Fórmula:C32H61N3O10P2Pureza:98%Forma y color:SolidPeso molecular:709.79HIF-2α-IN-2
CAS:HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Fórmula:C17H13F2NO4SPureza:99.24%Forma y color:SolidPeso molecular:365.35Ref: TM-T11561
1mg71,00€5mg135,00€10mg178,00€25mg309,00€50mg447,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)149,00€JPHM-2-167
CAS:PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Fórmula:C30H28N6O2Forma y color:SolidPeso molecular:504.582PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Fórmula:C24H23N7O2Pureza:98%Forma y color:SolidPeso molecular:441.49HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Fórmula:C12H6ClN5O5Pureza:98.11%Forma y color:SolidPeso molecular:335.66Ref: TM-T11562
1mg115,00€5mg274,00€10mg432,00€25mg845,00€50mg1.293,00€100mg1.768,00€1mL*10mM (DMSO)303,00€HNHA
CAS:HNHA is an inhibitor of HDAC.Fórmula:C17H21NO2SPureza:98.04%Forma y color:SolidPeso molecular:303.42Ref: TM-T21806
1mg44,00€5mg84,00€10mg135,00€25mg279,00€50mg445,00€100mg640,00€200mg879,00€1mL*10mM (DMSO)90,00€Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Fórmula:C21H19N3OSPureza:98.45%Forma y color:SolidPeso molecular:361.46HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Fórmula:C13H8Br2N2O2SPureza:98.32%Forma y color:SoildPeso molecular:416.09Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Fórmula:C12H15N3O2SPureza:98.21% - 98.76%Forma y color:Colorless Crystals SolidPeso molecular:265.33JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65Ref: TM-T3180
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg210,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Fórmula:C16H12O5Pureza:98.72% - 99.55%Forma y color:SolidPeso molecular:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Fórmula:C17H10F5NO4SPureza:98.8% - 99.07%Forma y color:SolidPeso molecular:419.32Ref: TM-T12675L
1mg99,00€5mg235,00€10mg354,00€25mg640,00€50mg944,00€100mg1.320,00€1mL*10mM (DMSO)259,00€ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Fórmula:C27H21N5Pureza:99.03%Forma y color:SolidPeso molecular:415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFórmula:C28H37FN4O4SPureza:98%Forma y color:SolidPeso molecular:544.68Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.80%Forma y color:SolidPeso molecular:656.79Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Fórmula:C16H18O9Pureza:98.76% - 99.67%Forma y color:SolidPeso molecular:354.31Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Fórmula:C23H28ClN3O7Pureza:100% - 99.89%Forma y color:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:White CrystalPeso molecular:277.25HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Fórmula:C16H8F5NO4SPureza:97.99%Forma y color:SolidPeso molecular:405.3Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Fórmula:C19H16N2O5Pureza:99% - 99.82%Forma y color:SolidPeso molecular:352.34Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Fórmula:C6H7K3O8Pureza:95%Forma y color:White Solid CrystallinePeso molecular:324.41THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFórmula:C11H12F3N3O3Pureza:100%Forma y color:SolidPeso molecular:291.23dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Fórmula:C5H8N2O5Pureza:≥95%Forma y color:SolidPeso molecular:176.13Ref: TM-TL0001
1mg49,00€5mg97,00€10mg169,00€25mg349,00€50mg520,00€100mg748,00€200mg1.026,00€1mL*10mM (DMSO)106,00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Fórmula:C28H35NO3Pureza:99.22%Forma y color:SolidPeso molecular:433.58Ref: TM-T13289
1mg107,00€5mg227,00€10mg378,00€25mg620,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)250,00€IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Fórmula:C15H16N6O3Pureza:99.97%Forma y color:SolidPeso molecular:328.33LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Fórmula:C26H29NO5Pureza:98.1% - 99.10%Forma y color:SolidPeso molecular:435.51Ref: TM-T3494
2mg47,00€5mg69,00€10mg89,00€25mg183,00€50mg298,00€100mg449,00€500mg938,00€1mL*10mM (DMSO)69,00€1,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFórmula:C13H8N2O3Pureza:97.75%Forma y color:SolidPeso molecular:240.21Ref: TM-T21653
5mg51,00€10mg84,00€25mg153,00€50mg235,00€100mg376,00€200mg553,00€500mg883,00€1mL*10mM (DMSO)57,00€Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Fórmula:C8H9ClN4Pureza:99.1% - 99.86%Forma y color:Yellow Crystals White Crystalline SolidPeso molecular:196.64M1001
CAS:M1001 is a HIF-2α agonist.Fórmula:C17H17N3O2SPureza:98.83%Forma y color:SolidPeso molecular:327.4FM19G11
CAS:FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).Fórmula:C23H17N3O8Pureza:97.28%Forma y color:SolidPeso molecular:463.4Acriflavine Hydrochloride
CAS:Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro and in vivo.Fórmula:C14H14ClN3Pureza:99.69%Forma y color:SolidPeso molecular:259.73PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Fórmula:C17H12F3NO4SPureza:98.69% - 99.55%Forma y color:SolidPeso molecular:383.34Ref: TM-T7848
1mg66,00€2mg87,00€5mg153,00€10mg258,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)126,00€MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Fórmula:C24H21N5O4Pureza:100% - 99.38%Forma y color:SolidPeso molecular:443.45Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.84%Forma y color:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecular:323.13AKB-6899
CAS:AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFórmula:C14H11FN2O4Pureza:97.11%Forma y color:SolidPeso molecular:290.25Ref: TM-T29797
1mg74,00€5mg169,00€10mg263,00€25mg455,00€50mg652,00€100mg929,00€1mL*10mM (DMSO)178,00€DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14(Rac)-PT2399
CAS:(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).Fórmula:C17H10F5NO4SForma y color:SolidPeso molecular:419.32HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFórmula:C26H24N2O3Pureza:99.48%Forma y color:SolidPeso molecular:412.48KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Fórmula:C25H24FNOPureza:98.31% - 99.61%Forma y color:SolidPeso molecular:373.46Glucosamine
CAS:Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Fórmula:C6H13NO5Pureza:99.80% - 99.80%Forma y color:CoaPeso molecular:179.17Vadadustat
CAS:Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Fórmula:C14H11ClN2O4Pureza:99.09% - 99.4%Forma y color:SolidPeso molecular:306.7ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Fórmula:C15H14N2O2SForma y color:SolidPeso molecular:286.35Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.47%Forma y color:SolidPeso molecular:349.41Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Fórmula:C6H13NO5·HClPureza:99.77%Forma y color:White Solid CrystallinePeso molecular:215.63HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Pureza:98%Forma y color:Odour SolidAmifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Fórmula:C5H15N2O3PSPureza:99.88%Forma y color:White SolidPeso molecular:214.22BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Fórmula:C26H26F3N7O2Pureza:98% - 99.77%Forma y color:SolidPeso molecular:525.53M1002
CAS:M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Fórmula:C15H8F6N2O2SPureza:99.73%Forma y color:SolidPeso molecular:394.29Ref: TM-T61822
1mg52,00€5mg97,00€10mg153,00€25mg249,00€50mg369,00€100mg545,00€500mg1.130,00€1mL*10mM (DMSO)114,00€ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Fórmula:C20H21N5O2Pureza:99.94%Forma y color:SolidPeso molecular:363.41Ref: TM-T13398
1mg48,00€5mg97,00€10mg160,00€25mg255,00€50mg353,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)105,00€HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Fórmula:C9H9N3O4S2Pureza:≥98%Forma y color:SolidPeso molecular:287.32ZG-2305
ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.Fórmula:C17H11Cl2N3O5Forma y color:SolidPeso molecular:408.19HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Fórmula:C17H12N2OPureza:99.48%Forma y color:SolidPeso molecular:260.29ENMD-1198
CAS:ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.Fórmula:C20H25NO2Pureza:98%Forma y color:SolidPeso molecular:311.42HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFórmula:C21H20ClN3OSPureza:98%Forma y color:SolidPeso molecular:397.92E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Fórmula:C21H30O6Pureza:98.83%Forma y color:SolidPeso molecular:378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Forma y color:SolidPeso molecular:485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PHD2-IN-1
CAS:PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Fórmula:C21H23ClN4O5Pureza:98%Forma y color:SolidPeso molecular:446.88KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Fórmula:C16H16Cl4N2O4S4Pureza:98% - 99.11%Forma y color:SolidPeso molecular:570.38Angiogenesis agent 1
CAS:Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Fórmula:C20H24O7Pureza:98%Forma y color:SolidPeso molecular:376.4(-)-Hydroxycitric acid lactone
CAS:(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, whichFórmula:C6H6O7Pureza:99.91%Forma y color:SolidPeso molecular:190.11AKBA
CAS:AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Fórmula:C32H48O5Pureza:97.85% - 99.77%Forma y color:SolidPeso molecular:512.72Ref: TM-T5S1569
1g1.863,00€1mg43,00€5mg88,00€10mg117,00€25mg187,00€50mg279,00€100mg439,00€500mg1.188,00€1mL*10mM (DMSO)143,00€Adaptaquin
CAS:Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Fórmula:C21H16ClN3O2Pureza:98.35%Forma y color:SolidPeso molecular:377.82PHD2-IN-4
CAS:PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Fórmula:C21H19N5O3Forma y color:SolidPeso molecular:389.407TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Fórmula:C13H14N4O3SPureza:99.07%Forma y color:SolidPeso molecular:306.34Ref: TM-T17105
1mg74,00€5mg164,00€10mg239,00€25mg430,00€50mg645,00€100mg940,00€200mg1.264,00€1mL*10mM (DMSO)170,00€Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Fórmula:C8H6N2S3Pureza:100% - 99.56%Forma y color:SolidPeso molecular:226.34UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H21N5O4Pureza:99.81%Forma y color:SolidPeso molecular:443.45Ref: TM-T9584
1mg86,00€2mg111,00€5mg180,00€10mg283,00€25mg455,00€50mg645,00€100mg882,00€500mg1.758,00€1mL*10mM (DMSO)188,00€Annaosanchun
CAS:Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Fórmula:C19H32O3Pureza:99.58%Forma y color:SolidPeso molecular:308.46AFP464 free base
CAS:AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Fórmula:C22H23F3N4O3Pureza:98%Forma y color:SolidPeso molecular:448.44PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Fórmula:C13H8N4Pureza:99.78%Forma y color:SolidPeso molecular:220.23Daprodustat
CAS:Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Fórmula:C19H27N3O6Pureza:97% - 99.82%Forma y color:SolidPeso molecular:393.43Ref: TM-T3197
1mg39,00€5mg75,00€10mg111,00€25mg177,00€50mg296,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)90,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.14%Forma y color:SolidPeso molecular:396.83PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Fórmula:C13H20Cl4N2O3Pureza:97% - ≥98%Forma y color:SolidPeso molecular:394.12FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:100% - 99%Forma y color:SolidPeso molecular:280.66
