ROR
Los receptores órfanos relacionados con el ácido retinoico (RORs) son receptores nucleares que regulan diversos procesos fisiológicos, incluyendo el ritmo circadiano, la respuesta inmunitaria y el metabolismo. Los inhibidores de ROR son de interés en el estudio de enfermedades autoinmunes, trastornos metabólicos y cáncer, ya que pueden modular la expresión génica e influir en las funciones celulares. En CymitQuimica, ofrecemos inhibidores de ROR para apoyar su investigación en inmunología, endocrinología y oncología.
Productos de "ROR"
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SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Fórmula:C13H9F6NO3S2Pureza:99.77%Forma y color:SolidPeso molecular:405.34T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.58%Forma y color:SolidPeso molecular:481.33Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Fórmula:C27H40O4Pureza:99.5% - 99.92%Forma y color:SolidPeso molecular:428.6Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Fórmula:C27H23F6NO6SPureza:99.92%Forma y color:SolidPeso molecular:603.53Ref: TM-TQ0007
1mg85,00€5mg147,00€10mg197,00€25mg329,00€50mg490,00€100mg710,00€1mL*10mM (DMSO)187,00€RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Fórmula:C27H37NO5SPeso molecular:487.651SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Fórmula:C26H24F7N3OPureza:98.2%Forma y color:SolidPeso molecular:527.48Ref: TM-T16929
1mg52,00€5mg96,00€10mg180,00€25mg274,00€50mg376,00€100mg533,00€500mg1.130,00€1mL*10mM (DMSO)120,00€RORγt inhibitor 4
CAS:RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.Fórmula:C22H16Cl2F3NO4SForma y color:SolidPeso molecular:518.333RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Fórmula:C24H28F3NO5SForma y color:SolidPeso molecular:499.54XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Fórmula:C25H20F7NO4SPureza:98.81%Forma y color:SolidPeso molecular:563.48Ref: TM-T13362
1mg87,00€5mg170,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€500mg1.691,00€1mL*10mM (DMSO)205,00€RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Fórmula:C26H33N7O2Pureza:98%Forma y color:SolidPeso molecular:475.59S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Forma y color:SolidPeso molecular:518.55Ref: TM-T16832
1mg57,00€5mg125,00€10mg188,00€25mg335,00€50mg470,00€100mg662,00€500mg1.320,00€1mL*10mM (DMSO)142,00€AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Fórmula:C21H18F6N2O5SPureza:99.75%Forma y color:SolidPeso molecular:524.43Ref: TM-T14369
1mg58,00€5mg135,00€10mg197,00€25mg306,00€50mg444,00€100mg562,00€1mL*10mM (DMSO)158,00€RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Fórmula:C26H26F8N2O6S2Pureza:98%Forma y color:SolidPeso molecular:678.61A-9758
CAS:A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Fórmula:C25H23Cl2F3N2O3Pureza:98%Forma y color:SolidPeso molecular:527.36RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Fórmula:C23H15Cl2F3N4O3SPureza:98%Forma y color:SolidPeso molecular:555.36SR0987
CAS:SR0987 is a RORγt agonist,Fórmula:C16H10ClF6NO2Pureza:99.43%Forma y color:SolidPeso molecular:397.7Ref: TM-T4670
2mg42,00€5mg59,00€10mg92,00€25mg188,00€50mg329,00€100mg490,00€200mg697,00€1mL*10mM (DMSO)66,00€FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Fórmula:C22H15ClF3N3O3Pureza:98%Forma y color:SolidPeso molecular:461.82
