FXR
El receptor X de farnesoide (FXR) es un receptor nuclear que desempeña un papel clave en la regulación de la homeostasis de los ácidos biliares, el metabolismo de los lípidos y la regulación de la glucosa. El FXR es un objetivo terapéutico potencial para el tratamiento de enfermedades hepáticas, trastornos metabólicos y enfermedades cardiovasculares. Los inhibidores del FXR pueden modular estas vías, ofreciendo información sobre los mecanismos de las enfermedades y las estrategias terapéuticas. En CymitQuimica, ofrecemos una gama de inhibidores del FXR para apoyar su investigación en hepatología, metabolismo y desarrollo de fármacos.
Productos de "FXR"
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Hay 43 productos en esta categoría.
Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Fórmula:C29H25F4N3O5SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€1mL*10mM (DMSO)213,00€T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.58%Forma y color:SolidPeso molecular:481.33Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.40% - 99.8%Forma y color:Light Yellow PowderPeso molecular:312.45Ref: TM-T5574
1mg35,00€5mg55,00€10mg93,00€25mg178,00€50mg245,00€100mg360,00€200mg532,00€1mL*10mM (DMSO)60,00€FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Fórmula:C15H22O4Forma y color:SolidPeso molecular:266.33Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Fórmula:C22H34O7Pureza:98.83% - 99.86%Forma y color:Less Crystalline Solid Colorless Crystalline SolidPeso molecular:410.5Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€LZ-007
CAS:LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Fórmula:C27H29F3N2O5Forma y color:SolidPeso molecular:518.53LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Fórmula:C28H27Cl2N3O4Pureza:99.16% - 99.78%Forma y color:SolidPeso molecular:540.44Ref: TM-T15806
1mg104,00€5mg227,00€10mg369,00€25mg740,00€50mg1.169,00€100mg1.568,00€200mg2.118,00€1mL*10mM (DMSO)269,00€Lecufexor
CAS:Lecufexor is an agonist of the farnesoid X receptor (FXR).Fórmula:C32H21Cl3N2O5Forma y color:SolidPeso molecular:619.88FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Fórmula:C18H16N2O5Forma y color:SolidPeso molecular:340.33FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Fórmula:C28H30N2O5Forma y color:SolidPeso molecular:474.55Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFórmula:C19H15Cl3N2O5SPureza:98.74%Forma y color:SolidPeso molecular:489.76Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.Fórmula:C24H40O4Pureza:99.74% - ≥95%Forma y color:White - Almost White Solid PowderPeso molecular:392.57Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Fórmula:C24H40NaO4Pureza:98% - 98.55%Forma y color:SolidPeso molecular:415.56NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Forma y color:Lyophilized PowderPeso molecular:27.80 kDa (predicted)Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFórmula:(C3H7N·C3H5ClO·HCl)xPureza:98%Forma y color:SolidPeso molecular:186.08BAR-2227
CAS:BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Fórmula:C24H17Cl2NO4Forma y color:SolidPeso molecular:454.30INT-767
CAS:INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial functionFórmula:C25H43NaO6SPureza:98%Forma y color:SolidPeso molecular:494.66Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Fórmula:C26H44O4Pureza:99.88% - 99.97%Forma y color:SolidPeso molecular:420.63Ref: TM-T1789
5mg48,00€10mg52,00€25mg82,00€50mg99,00€100mg163,00€200mg274,00€500mg505,00€1mL*10mM (DMSO)49,00€Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Fórmula:C20H18FNO4Pureza:98.83% - 99.58%Forma y color:SolidPeso molecular:355.36Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Fórmula:C28H22Cl3N3O5Pureza:99.32% - ≥95%Forma y color:SolidPeso molecular:586.85Ref: TM-T7436
1mg50,00€2mg73,00€5mg124,00€10mg188,00€25mg380,00€50mg567,00€100mg807,00€500mg1.644,00€1mL*10mM (DMSO)158,00€BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Forma y color:SolidPeso molecular:392.62Chenodeoxycholic acid
CAS:Chenodeoxycholic acid (CDCA), a bile acid, usually conjugated with either glycine or taurine, acts as a detergent to solubilize fats for intestinal absorption.Fórmula:C24H40O4Pureza:99.70% - 99.72%Forma y color:White - Almost White Solid PowderPeso molecular:392.57FXR agonist 5
CAS:FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Fórmula:C40H53N5O5Pureza:99.74%Forma y color:SolidPeso molecular:683.88Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Fórmula:C27H22ClN3O4Pureza:98.67%Forma y color:SolidPeso molecular:487.93GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Fórmula:C28H22Cl3NO4Pureza:97.47% - 99.94%Forma y color:SolidPeso molecular:542.84Ref: TM-T2233
5mg50,00€10mg84,00€25mg139,00€50mg235,00€100mg424,00€200mg640,00€500mg1.008,00€1mL*10mM (DMSO)63,00€LH10
LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).Fórmula:C34H33N3O2Forma y color:SolidPeso molecular:515.64Gly-β-MCA
CAS:Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.Fórmula:C26H43NO6Pureza:≥98.0%Forma y color:SolidPeso molecular:465.62LY367385
CAS:LY367385 is a highly effective and selective mGluR1a antagonist.Fórmula:C10H11NO4Pureza:98%Forma y color:SolidPeso molecular:209.2ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.Fórmula:C29H23Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:520.4FXR/CES2 modulator 1
CAS:Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.Fórmula:C27H21Cl2NO5Forma y color:SolidPeso molecular:510.36NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:27.83 kDa (predicted)Glyco-Obeticholic acid
CAS:Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Fórmula:C28H47NO5Pureza:99.77% - 99.95%Forma y color:SolidPeso molecular:477.68Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Fórmula:C32H36N2O3Pureza:98.87% - 99.61%Forma y color:SolidPeso molecular:496.64Osocimab
CAS:Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and reduces thrombosis in research.Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:144.46 kDaFXR agonist 12
CAS:FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.Fórmula:C26H44O3Forma y color:SolidPeso molecular:404.626GSK2324
CAS:GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.Fórmula:C29H22Cl2N2O4Pureza:100% - 98.50%Forma y color:SolidPeso molecular:533.4NDB
CAS:NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.Fórmula:C26H28Cl2N2O2Pureza:98.94%Forma y color:SolidPeso molecular:471.42Tauro-β-muricholic acid sodium
CAS:Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).Fórmula:C26H44NNaO7SPureza:98%Forma y color:SolidPeso molecular:537.69Tauro-β-muricholic acid
CAS:Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptoticFórmula:C26H45NO7SPureza:98%Forma y color:SolidPeso molecular:515.7Chenodeoxycholic Acid sodium salt
CAS:Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.Fórmula:C24H39NaO4Pureza:99.68% - 99.72%Forma y color:SolidPeso molecular:414.55Tauro-Obeticholic acid
CAS:Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Fórmula:C28H49NO6SPureza:99.82% - 99.82%Forma y color:SolidPeso molecular:527.76Ref: TM-T13092
1mg117,00€5mg274,00€10mg414,00€25mg685,00€50mg938,00€100mg1.311,00€1mL*10mM (DMSO)349,00€Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFórmula:C25H24F2N2O3Pureza:99.33% - 99.73%Forma y color:SolidPeso molecular:438.47DY268
CAS:DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Fórmula:C30H32N4O5SPureza:98.48% - 99.43%Forma y color:SolidPeso molecular:560.66Ref: TM-T31587
1mg40,00€5mg88,00€10mg126,00€25mg245,00€50mg454,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)87,00€
