GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Productos de "GluR"
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Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Fórmula:C12H20N2O8S2Pureza:98%Forma y color:SolidPeso molecular:384.43NPS2390
CAS:NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)Fórmula:C19H21N3OPureza:97.13%Forma y color:SolidPeso molecular:307.39VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Fórmula:C18H14F2N6OSPureza:98%Forma y color:SolidPeso molecular:400.41Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Fórmula:C16H10F3N5Pureza:97.38%Forma y color:SolidPeso molecular:329.28(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Fórmula:C7H11ClN2O4Forma y color:SolidPeso molecular:222.63LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Forma y color:SolidPeso molecular:539.59CDPPB
CAS:CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).Fórmula:C23H16N4OPureza:99.16%Forma y color:SolidPeso molecular:364.4YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Fórmula:C11H8ClN5O4Pureza:100%Forma y color:SolidPeso molecular:309.66ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Fórmula:C15H16N2OPureza:97.85%Forma y color:SolidPeso molecular:240.3VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Fórmula:C16H19N3O3SPureza:98%Forma y color:SolidPeso molecular:333.41LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Fórmula:C18H20ClNO4Pureza:99% - 99.32%Forma y color:SoildPeso molecular:349.81LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Fórmula:C18H23NO4Pureza:98.06% - 98.71%Forma y color:SolidPeso molecular:317.38CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFórmula:C19H13ClF3N3OPureza:99.17%Forma y color:SolidPeso molecular:391.77Ref: TM-T6457
2mg37,00€5mg52,00€10mg93,00€25mg145,00€50mg256,00€100mg349,00€200mg495,00€1mL*10mM (DMSO)58,00€mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Fórmula:C16H21N3OPureza:98.99%Forma y color:SolidPeso molecular:271.36VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Fórmula:C22H28N4OPureza:97.27%Forma y color:SolidPeso molecular:364.48Ref: TM-T29118
1mg44,00€5mg84,00€10mg114,00€25mg221,00€50mg329,00€100mg490,00€200mg677,00€1mL*10mM (DMSO)95,00€CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFórmula:C13H13NO4Pureza:99.87%Forma y color:SolidPeso molecular:247.25Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Fórmula:C18H11F3N2O3Pureza:97.57%Forma y color:SolidPeso molecular:360.29(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Fórmula:C9H9NO4Pureza:99.96%Forma y color:SolidPeso molecular:195.17Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Fórmula:C13H10N2OPureza:99.20%Forma y color:SolidPeso molecular:210.23BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Fórmula:C23H14ClF3N4Pureza:99.62%Forma y color:SolidPeso molecular:438.83Licostinel
CAS:Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.Fórmula:C8H3Cl2N3O4Pureza:98.02%Forma y color:SolidPeso molecular:276.031-BCP
CAS:1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.Fórmula:C13H15NO3Pureza:99.60%Forma y color:SolidPeso molecular:233.26Chelidamic acid
CAS:Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.Fórmula:C7H5NO5Pureza:98.11%Forma y color:Pale Yellow PowderPeso molecular:183.12DL-AP3
CAS:DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.Fórmula:C3H8NO5PPureza:98.18% - ≥98%Forma y color:White PowderPeso molecular:169.07VU6012962
CAS:VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).Fórmula:C21H19F3N4O4Pureza:97% - 98.31%Forma y color:SolidPeso molecular:448.4Ref: TM-T13323
1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg236,00€50mg425,00€100mg625,00€1mL*10mM (DMSO)87,00€GYKI 52466 dihydrochloride
CAS:GYKI 52466 dihydrochloride is an AMPA/Kainate receptor antagonist with anticonvulsant activity and can be used to study neurological diseases.Fórmula:C17H17Cl2N3O2Pureza:99.38%Forma y color:SolidPeso molecular:366.24Pomaglumetad methionil anhydrous
CAS:LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.Fórmula:C12H18N2O7S2Pureza:98%Forma y color:SolidPeso molecular:366.41CX516
CAS:CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.Fórmula:C14H15N3OPureza:99.29% - ≥95%Forma y color:Tan SolidPeso molecular:241.29Transtorine
CAS:Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.Fórmula:C10H7NO3Pureza:99.36%Forma y color:SolidPeso molecular:189.17HBT1
CAS:HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neuronsFórmula:C16H17F3N4O2SPureza:99.52%Forma y color:SolidPeso molecular:386.39MNI 137
CAS:MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.Fórmula:C15H9BrN4OPureza:97.21%Forma y color:SolidPeso molecular:341.16trans-ACPD
CAS:trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.Fórmula:C7H11NO4Pureza:99.53%Forma y color:SolidPeso molecular:173.17Ref: TM-T3484
1mg48,00€2mg63,00€5mg89,00€10mg147,00€25mg279,00€50mg505,00€100mg730,00€1mL*10mM (DMSO)74,00€CFMTI
CAS:CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.Fórmula:C19H16FN5OPureza:97.23%Forma y color:SolidPeso molecular:349.36Ref: TM-T3482
1mg60,00€2mg87,00€5mg127,00€10mg180,00€25mg321,00€50mg455,00€100mg635,00€1mL*10mM (DMSO)140,00€(R)-3,4-DCPG HCl
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatalFórmula:C10H10ClNO6Pureza:98.36% - 99.89%Forma y color:SoildPeso molecular:275.64(R)-ADX-47273
CAS:(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).Fórmula:C20H17F2N3O2Pureza:99.87%Forma y color:SolidPeso molecular:369.36Ref: TM-T13441
2mg42,00€5mg65,00€10mg94,00€25mg170,00€50mg259,00€100mg391,00€200mg545,00€1mL*10mM (DMSO)71,00€AMPA receptor modulator-2
CAS:AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.Fórmula:C15H6F6N4OSPureza:99.62%Forma y color:SolidPeso molecular:404.29Ref: TM-T37734
1mg123,00€5mg298,00€10mg393,00€25mg628,00€50mg905,00€100mg1.254,00€1mL*10mM (DMSO)328,00€VU0155094
CAS:VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.Fórmula:C24H24N2O4SPureza:98.00%Forma y color:SolidPeso molecular:436.52Ref: TM-T9011
1mg65,00€5mg116,00€10mg170,00€25mg284,00€50mg393,00€100mg567,00€200mg748,00€1mL*10mM (DMSO)134,00€MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Fórmula:C15H9FN2Pureza:98.82%Forma y color:SolidPeso molecular:236.24Farampator
CAS:Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.Fórmula:C12H13N3O2Pureza:99.76% - 99.83%Forma y color:SolidPeso molecular:231.25Ref: TM-T3957
2mg34,00€5mg52,00€10mg74,00€25mg140,00€50mg235,00€100mg350,00€200mg497,00€1mL*10mM (DMSO)58,00€JNJ-42153605
CAS:JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).Fórmula:C22H23F3N4Pureza:97.25% - 98.57%Forma y color:SolidPeso molecular:400.44Ref: TM-T3451
1mg34,00€2mg52,00€5mg81,00€10mg105,00€25mg180,00€50mg279,00€100mg396,00€200mg555,00€1mL*10mM (DMSO)84,00€LY2979165
CAS:LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.Fórmula:C13H22N6O6SPureza:100.00%Forma y color:SolidPeso molecular:390.42MPEP hydrochloride
CAS:MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).Fórmula:C14H12ClNPureza:100% - 99.75%Forma y color:SolidPeso molecular:229.7AZD-8529 mesylate
CAS:AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).Fórmula:C25H28F3N5O6SPureza:99.19%Forma y color:SolidPeso molecular:583.58Ref: TM-T10432L
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.093,00€200mg1.454,00€1mL*10mM (DMSO)156,00€LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Fórmula:C20H19NO5Pureza:98.53% - 99.37%Forma y color:SolidPeso molecular:353.37(1R,2S)-VU0155041
CAS:(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.Fórmula:C14H15Cl2NO3Pureza:99.73%Forma y color:SolidPeso molecular:316.18KM02894
CAS:KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.Fórmula:C7H9N3OS2Pureza:98.72%Forma y color:SolidPeso molecular:215.3CMPDA
CAS:CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].Fórmula:C16H28N2O4S2Pureza:98%Forma y color:SolidPeso molecular:376.53
