p97
Los inhibidores de p97 son compuestos que inhiben p97, también conocido como Proteína Contenedora de Valosina (VCP), un ATPasa involucrado en diversos procesos celulares, como la degradación de proteínas, la regulación del ciclo celular y la reparación del ADN. p97 es un jugador clave en el sistema ubiquitina-proteasoma, y su inhibición es de gran interés en la investigación del cáncer, enfermedades neurodegenerativas y otros trastornos donde se ve alterada la homeostasis proteica. En CymitQuimica, ofrecemos inhibidores de p97 para apoyar su investigación en proteostasis, neurobiología y terapia contra el cáncer.
Productos de "p97"
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Hay 15 productos en esta categoría.
CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:98.5%Forma y color:SoildPeso molecular:412.49ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:100% - 99.66%Forma y color:SolidPeso molecular:396.44Ref: TM-T3535
1mg38,00€5mg81,00€10mg116,00€25mg205,00€50mg329,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)88,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Forma y color:SolidPeso molecular:408.92CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:100% - 99.92%Forma y color:SolidPeso molecular:413.47Ref: TM-T6796
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg298,00€50mg469,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)97,00€NSC799462
NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.Fórmula:C30H32F2N6O3SForma y color:SolidPeso molecular:594.68UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.5%Forma y color:SolidPeso molecular:520.67NSC819701
NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.Fórmula:C30H32F2N8O3SForma y color:SolidPeso molecular:622.69UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C23H16ClN3O3SForma y color:SolidPeso molecular:449.91ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Fórmula:C23H24N4OPureza:98%Forma y color:SolidPeso molecular:372.46DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Fórmula:C22H20N4Pureza:98.89% - ≥95%Forma y color:SolidPeso molecular:340.42Ref: TM-T1969
5mg58,00€10mg95,00€25mg180,00€50mg324,00€100mg410,00€200mg607,00€500mg938,00€1mL*10mM (DMSO)59,00€NPD8733
CAS:NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.Fórmula:C18H15NO4Pureza:98.48%Forma y color:SolidPeso molecular:309.32Ref: TM-T9008
1mg42,00€5mg87,00€10mg125,00€25mg245,00€50mg399,00€100mg645,00€500mg1.311,00€1mL*10mM (DMSO)183,00€MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55
