Células madre y Derivados
Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.
Subcategorías de "Células madre y Derivados"
- Gamma-secretasa
- Hedgehog / Smoothened
- Hippo pathway
- JAK
- Porcupine (Puerco espín)
- ROCK
- STAT
- Células madre
- TGF-beta / Smad
- Wnt / beta-catenina
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Productos de "Células madre y Derivados"
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Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Fórmula:C23H22N6O2Pureza:97.47% - 99.56%Forma y color:SolidPeso molecular:414.46Ref: TM-T1849
1mg38,00€2mg49,00€5mg81,00€10mg95,00€25mg166,00€50mg259,00€100mg406,00€200mg625,00€1mL*10mM (DMSO)88,00€GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:98.8%Forma y color:SolidPeso molecular:313.42Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Forma y color:SolidPeso molecular:452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:97.10% - 98.54%Forma y color:SolidPeso molecular:358.18Ref: TM-T3156
2mg42,00€5mg59,00€10mg85,00€25mg168,00€50mg235,00€100mg331,00€200mg492,00€1mL*10mM (DMSO)69,00€GNE-7883
CAS:GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Fórmula:C28H29FN6O2Pureza:97.61%Forma y color:SolidPeso molecular:500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€Aβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C35H49NPureza:99.14%Forma y color:SoildPeso molecular:483.77Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Forma y color:LiquidRuxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Fórmula:C17H18N6Pureza:99.37% - 99.79%Forma y color:SolidPeso molecular:306.36CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:98.34% - 99.01%Forma y color:SolidPeso molecular:466.46JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.Fórmula:C20H24N6O2SPureza:98%Forma y color:SolidPeso molecular:412.51YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Fórmula:C25H24ClFN2O4Pureza:98%Forma y color:SolidPeso molecular:470.92ROCK-IN-6
CAS:ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1Fórmula:C19H19N5O8SPureza:98%Forma y color:SolidPeso molecular:477.45WAY-656935
CAS:WAY-656935 inhibits ROCK.Fórmula:C20H28ClN3O3SPureza:98.1%Forma y color:SolidPeso molecular:425.97Amcasertib
CAS:Amcasertib (BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways via targeting stemness kinases.Fórmula:C31H33N5O2SPureza:100% - 99.31%Forma y color:SolidPeso molecular:539.69Zelasudil
CAS:Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.Fórmula:C22H21F2N7OPureza:99.15%Forma y color:SolidPeso molecular:437.445Ref: TM-T69665
1mg92,00€5mg180,00€10mg274,00€25mg469,00€50mg653,00€100mg912,00€200mg1.225,00€1mL*10mM (DMSO)188,00€Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.51%Forma y color:SolidPeso molecular:352.5Ref: TM-T12721
1mg74,00€5mg145,00€10mg215,00€25mg378,00€50mg530,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)111,00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Forma y color:Yellow SolidPeso molecular:294.3ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Forma y color:SolidPeso molecular:402.79Ref: TM-TQ0110
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€1mL*10mM (DMSO)373,00€SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Forma y color:SolidPeso molecular:286.29Ref: TM-T6989
5mg40,00€10mg60,00€25mg107,00€50mg185,00€100mg339,00€200mg510,00€500mg797,00€1mL*10mM (DMSO)66,00€RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Fórmula:C16H14N4O2SPureza:98% - 99.73%Forma y color:SolidPeso molecular:326.37Ref: TM-T1898
5mg51,00€10mg87,00€25mg187,00€50mg311,00€100mg414,00€200mg520,00€500mg840,00€1mL*10mM (DMSO)57,00€
