Células madre y Derivados
Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.
Subcategorías de "Células madre y Derivados"
- Gamma-secretasa
- Hedgehog / Smoothened
- Hippo pathway
- JAK
- Porcupine (Puerco espín)
- ROCK
- STAT
- Células madre
- TGF-beta / Smad
- Wnt / beta-catenina
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Productos de "Células madre y Derivados"
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SAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Fórmula:C28H30Cl3N3OSPureza:100%Forma y color:SoildPeso molecular:562.984-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:99.56%Forma y color:White To Beige SolidPeso molecular:233.49exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44Ref: TM-T22775
5mg34,00€10mg52,00€25mg105,00€50mg173,00€100mg279,00€200mg406,00€1mL*10mM (DMSO)44,00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Fórmula:C31H31F3N8O4Forma y color:SolidPeso molecular:639.64ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Fórmula:C18H14N4OSPureza:98.53%Forma y color:SolidPeso molecular:334.39Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Fórmula:C95H128F3N25O28S3Pureza:99.48%Forma y color:SolidPeso molecular:2221.37Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Forma y color:SolidPeso molecular:754.83TTP 22
CAS:TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.Fórmula:C16H14N2O2S2Pureza:97.08% - 97.78%Forma y color:SolidPeso molecular:330.42Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.82%Forma y color:SolidPeso molecular:334.39Ref: TM-T9053
1mg73,00€5mg145,00€10mg220,00€25mg437,00€50mg567,00€100mg805,00€200mg1.111,00€1mL*10mM (DMSO)161,00€Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Fórmula:C28H26N2O12P2Pureza:98.97%Forma y color:SolidPeso molecular:644.46Ref: TM-T9646
1mg208,00€5mg518,00€10mg740,00€25mg1.093,00€50mg1.473,00€100mg2.015,00€1mL*10mM (DMSO)737,00€Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Fórmula:C27H36N6O3SPureza:98.23% - 99.96%Forma y color:SolidPeso molecular:524.68Ref: TM-T1995
1g625,00€5mg49,00€10mg69,00€50mg113,00€100mg134,00€200mg216,00€500mg472,00€1mL*10mM (DMSO)57,00€Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Fórmula:C24H25N7O2Forma y color:SolidPeso molecular:443.50Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Fórmula:C18H21F2N7OPureza:99.8%Forma y color:SolidPeso molecular:389.4Ref: TM-TQ0010
1mg35,00€5mg74,00€10mg110,00€25mg226,00€50mg411,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)81,00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Fórmula:C14H5F6N5OPureza:98.85% - ≥98%Forma y color:SolidPeso molecular:373.21Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:100% - 99.79%Forma y color:SolidPeso molecular:371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Fórmula:C16H18O4Pureza:98.66% - 99.48%Forma y color:SolidPeso molecular:274.31Ref: TM-TL0008
1mg49,00€2mg65,00€5mg97,00€10mg156,00€25mg255,00€50mg373,00€100mg555,00€1mL*10mM (DMSO)165,00€SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Fórmula:C14H14ClFN2O2Pureza:99.83%Forma y color:SolidPeso molecular:296.72Ref: TM-T60644
1mg52,00€5mg97,00€10mg149,00€25mg283,00€50mg550,00€100mg792,00€500mg1.605,00€1mL*10mM (DMSO)96,00€JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Forma y color:SolidPeso molecular:521.59Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Fórmula:C14H18ClN3O3SPureza:99.82%Forma y color:SolidPeso molecular:343.83Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Fórmula:C27H41NO2Pureza:98.31% - 99.66%Forma y color:White Crystalline SolidPeso molecular:411.62BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.75%Forma y color:SolidPeso molecular:347.45HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFórmula:C24H23ClN4O3Pureza:95.73%Forma y color:SolidPeso molecular:450.92Ref: TM-T3460
1mg52,00€5mg97,00€10mg178,00€25mg379,00€50mg645,00€100mg1.026,00€1mL*10mM (DMSO)110,00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Fórmula:C24H40O2Pureza:99.89%Forma y color:SoildPeso molecular:360.57
