Células madre y Derivados
Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.
Subcategorías de "Células madre y Derivados"
- Gamma-secretasa
- Hedgehog / Smoothened
- Hippo pathway
- JAK
- Porcupine (Puerco espín)
- ROCK
- STAT
- Células madre
- TGF-beta / Smad
- Wnt / beta-catenina
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Productos de "Células madre y Derivados"
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IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Ac-VDVAD-CHO
CAS:Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].Fórmula:C23H37N5O10Pureza:98%Forma y color:SolidPeso molecular:543.57Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Fórmula:C22H23F2N3O2SPureza:99.49%Forma y color:SolidPeso molecular:431.5Povorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Fórmula:C23H25F5N7O5PPureza:97.71%Forma y color:SolidPeso molecular:605.45Ref: TM-T39113L
1mg65,00€2mg95,00€5mg145,00€10mg212,00€25mg359,00€50mg512,00€100mg695,00€200mg937,00€SANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Fórmula:C26H26ClN3O4Pureza:99.23%Forma y color:SolidPeso molecular:479.96Wnt pathway inhibitor 3
CAS:Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFórmula:C21H17BrN2O5Pureza:99.69%Forma y color:SoildPeso molecular:457.27E 2012
CAS:E2012 is a γ-secretase modulator (GSM).Fórmula:C25H26FN3O2Pureza:99.18%Forma y color:SolidPeso molecular:419.49AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Fórmula:C22H16Cl2F3N3O3SPureza:99.16% - 99.60%Forma y color:SolidPeso molecular:530.35Ref: TM-T63730
1mg150,00€5mg364,00€10mg588,00€25mg1.169,00€50mg1.882,00€100mg2.822,00€1mL*10mM (DMSO)426,00€IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C13H11NO5S2Pureza:97.1% - 99.06%Forma y color:SolidPeso molecular:325.36GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Forma y color:Odour SolidSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Fórmula:C16H15NO3SForma y color:SolidPeso molecular:301.36JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Pureza:98%Forma y color:Odour SolidCDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Fórmula:C21H20ClN3O2Pureza:98.97% - 99.83%Forma y color:SoildPeso molecular:381.86Ref: TM-T72048
1mg52,00€5mg101,00€10mg150,00€25mg250,00€50mg363,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)116,00€KY-05009
CAS:KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Fórmula:C18H16N4O2SPureza:98.06%Forma y color:SolidPeso molecular:352.41Ref: TM-T11793
5mg50,00€10mg71,00€25mg117,00€50mg170,00€100mg245,00€200mg354,00€1mL*10mM (DMSO)51,00€Neocucurbitacin A
CAS:Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Fórmula:C31H42O8Pureza:98%Forma y color:SolidPeso molecular:542.66RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:97.29% - 99.91%Forma y color:SolidPeso molecular:545.63Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Fórmula:C18H22N4O2Pureza:98.67% - 99.4%Forma y color:SolidPeso molecular:326.39Ref: TM-T6933
2mg40,00€5mg66,00€10mg104,00€25mg182,00€50mg283,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)73,00€LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Fórmula:C23H20N6OPureza:100% - ≥98%Forma y color:SolidPeso molecular:396.44Ref: TM-T2618
1mg48,00€2mg65,00€5mg96,00€10mg164,00€25mg304,00€50mg545,00€100mg778,00€1mL*10mM (DMSO)96,00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Fórmula:C28H32O6Pureza:96.39% - 97.90%Forma y color:SolidPeso molecular:464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Fórmula:C21H23N7O3SPureza:98% - 99.25%Forma y color:SolidPeso molecular:453.52Ref: TM-T1957
1mg38,00€2mg49,00€5mg79,00€10mg106,00€25mg198,00€50mg374,00€100mg555,00€500mg1.206,00€1mL*10mM (DMSO)108,00€RU-SKI 43
CAS:RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Fórmula:C22H30N2O2SPureza:99.78%Forma y color:SolidPeso molecular:386.55Epiblastin A
CAS:Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.Fórmula:C12H10ClN7Pureza:99.45%Forma y color:SolidPeso molecular:287.71Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Fórmula:C20H28ClN7O3SPureza:99.23%Forma y color:SolidPeso molecular:482SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Fórmula:C16H24BrClN2OPureza:100%Forma y color:SolidPeso molecular:375.73Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.11%Forma y color:SoildPeso molecular:1640.88IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Fórmula:C22H17FN4O2S3Pureza:98.38%Forma y color:SolidPeso molecular:484.59GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Fórmula:C19H16FN5O2Pureza:98.16% - 98.44%Forma y color:SolidPeso molecular:365.36Ref: TM-T3513
1mg42,00€2mg52,00€5mg73,00€10mg88,00€25mg170,00€50mg306,00€100mg568,00€500mg1.225,00€1mL*10mM (DMSO)65,00€Tolnaftate
CAS:Tolnaftate (NP-27) is a synthetic antifungal agent.Fórmula:C19H17NOSPureza:98.85%Forma y color:White PowderPeso molecular:307.41MSC-4106
CAS:MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.Fórmula:C18H12F3N3O2Pureza:100%Forma y color:SoildPeso molecular:359.3Ref: TM-T60148
1mg96,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€200mg1.634,00€1mL*10mM (DMSO)271,00€Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Forma y color:SolidPeso molecular:445.54Ref: TM-T2487
1mg44,00€2mg55,00€5mg79,00€10mg106,00€25mg185,00€50mg283,00€100mg432,00€200mg605,00€500mg938,00€1mL*10mM (DMSO)86,00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Fórmula:C22H28N6O8Pureza:99.19% - 99.75%Forma y color:SolidPeso molecular:504.49TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:97.38% - 99.1%Forma y color:SolidPeso molecular:504.64AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Fórmula:C12H12N4O4SPureza:99.94% - ≥95%Forma y color:SolidPeso molecular:308.31Aloisine B
CAS:Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Fórmula:C15H14ClN3Pureza:95.15%Forma y color:SolidPeso molecular:271.74Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.23%Forma y color:SolidPeso molecular:334.41Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Fórmula:C20H26O5Pureza:100% - 99.74%Forma y color:SolidPeso molecular:346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFórmula:C21H19N5OPureza:98%Forma y color:SolidPeso molecular:357.41Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Fórmula:C12H13N3OPureza:98.27%Forma y color:SolidPeso molecular:215.25Wnt/β-catenin agonist 2
CAS:Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Fórmula:C13H12N4O3Pureza:99.58%Forma y color:SolidPeso molecular:272.26Ref: TM-T41094
1mg54,00€5mg116,00€10mg187,00€25mg318,00€50mg449,00€100mg638,00€500mg1.264,00€1mL*10mM (DMSO)111,00€Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Forma y color:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)177,00€CUR61414
CAS:CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Fórmula:C31H42N4O5Pureza:97.34% - 98.00%Forma y color:SolidPeso molecular:550.69Ref: TM-T15019
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)123,00€LSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Fórmula:C23H43F3N6O7Pureza:99.33%Forma y color:SolidPeso molecular:572.62CCG 203769
CAS:CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Fórmula:C8H14N2O2SPureza:99.46%Forma y color:SolidPeso molecular:202.27Ref: TM-T10705
1mg88,00€5mg187,00€10mg264,00€25mg469,00€50mg657,00€100mg944,00€500mg1.882,00€1mL*10mM (DMSO)207,00€DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Fórmula:C13H17ClO4Pureza:99.57%Forma y color:SolidPeso molecular:272.72Ref: TM-T60485
1mg92,00€5mg235,00€10mg350,00€25mg588,00€50mg838,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)215,00€2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Fórmula:C16H13Cl2N3O2Pureza:98.77%Forma y color:SolidPeso molecular:350.2SAG 21k
CAS:SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Fórmula:C29H28ClF2N3O2SPureza:99.51%Forma y color:SolidPeso molecular:556.07BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Fórmula:C14H10BrNOSPureza:99.48% - 99.94%Forma y color:SolidPeso molecular:320.2Ref: TM-T7799
5mg47,00€10mg60,00€25mg88,00€50mg126,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Fórmula:C19H23ClN2O3SPureza:99.53%Forma y color:SoildPeso molecular:394.92JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFórmula:C19H18N4O3Pureza:97.46% - 99.94%Forma y color:SolidPeso molecular:350.37
