Células madre y Derivados
Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.
Subcategorías de "Células madre y Derivados"
- Gamma-secretasa
- Hedgehog / Smoothened
- Hippo pathway
- JAK
- Porcupine (Puerco espín)
- ROCK
- STAT
- Células madre
- TGF-beta / Smad
- Wnt / beta-catenina
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Productos de "Células madre y Derivados"
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DC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.Fórmula:C19H17NO2SPureza:98.82%Forma y color:SoildPeso molecular:323.41SRI 37892
CAS:SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.Fórmula:C26H19N5O2SPureza:98.92%Forma y color:SolidPeso molecular:465.53Ref: TM-T9662
1mg378,00€5mg922,00€10mg1.225,00€25mg1.853,00€50mg2.490,00€100mg3.353,00€1mL*10mM (DMSO)1.074,00€GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Fórmula:C20H16N2O2Pureza:99.44%Forma y color:SoildPeso molecular:316.35Ref: TM-T64351
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)249,00€GSA-10
CAS:GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Fórmula:C26H30N2O5Pureza:≥98%Forma y color:SolidPeso molecular:450.53Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Fórmula:C24H28N8O2Pureza:98.06% - 99.94%Forma y color:SolidPeso molecular:460.53Ref: TM-T14331
1mg42,00€5mg88,00€10mg123,00€25mg188,00€50mg350,00€100mg522,00€200mg750,00€1mL*10mM (DMSO)116,00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97% - 98.03%Forma y color:SolidPeso molecular:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Fórmula:C28H30N8O2Forma y color:SolidPeso molecular:510.59HJC0152 free base
CAS:HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFórmula:C15H13Cl2N3O4Pureza:98%Forma y color:SolidPeso molecular:370.19Sonidegib diphosphate
CAS:Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.Fórmula:C26H32F3N3O11P2Pureza:99.48%Forma y color:SolidPeso molecular:681.49Ref: TM-T15727
1g852,00€5g2.133,00€10g3.201,00€5mg50,00€10mg57,00€25mg90,00€50mg114,00€100mg188,00€1mL*10mM (DMSO)72,00€ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂,适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Forma y color:SolidPeso molecular:521.95Momelotinib sulfate
CAS:Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Fórmula:C23H26N6O10S2Pureza:98%Forma y color:SolidPeso molecular:610.62MRK-560
CAS:MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.Fórmula:C19H17ClF5NO4S2Pureza:98.87%Forma y color:SolidPeso molecular:517.92FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Fórmula:C18H14N2O4Pureza:100%Forma y color:SolidPeso molecular:322.31Ref: TM-T15363
2mg42,00€5mg60,00€10mg96,00€25mg177,00€50mg283,00€100mg454,00€200mg653,00€1mL*10mM (DMSO)95,00€JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFórmula:C22H24N6O3Pureza:98%Forma y color:SolidPeso molecular:420.46Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.01%Forma y color:SolidPeso molecular:456.92QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFórmula:C26H27N7O3Pureza:98%Forma y color:SolidPeso molecular:485.54GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SForma y color:SolidPeso molecular:312.35PI-828
CAS:PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.Fórmula:C19H18N2O3Pureza:99.39%Forma y color:SolidPeso molecular:322.36Ref: TM-T16528
1mg35,00€5mg78,00€10mg117,00€25mg197,00€50mg283,00€100mg386,00€200mg550,00€1mL*10mM (DMSO)55,00€SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Fórmula:C20H21N7OPureza:99.41%Forma y color:SolidPeso molecular:375.43CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent inhibitor of CK1, exhibiting IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a [1].Fórmula:C17H12FN3O2Pureza:98%Forma y color:SolidPeso molecular:309.29
