Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Productos de "Wnt / beta-catenina"
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BML-284 hydrochloride
CAS:BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.Fórmula:C19H19ClN4O3Pureza:99.80%Forma y color:SolidPeso molecular:386.84Ref: TM-T8820
1mg35,00€5mg67,00€10mg88,00€25mg150,00€50mg266,00€100mg462,00€200mg648,00€500mg1.017,00€1mL*10mM (DMSO)89,00€Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Fórmula:C25H21N3OPureza:99.56% - 99.95%Forma y color:SolidPeso molecular:379.45TNIK-IN-2
CAS:TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.Fórmula:C22H19N3O3Pureza:98.09%Forma y color:SolidPeso molecular:373.4Hematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Fórmula:C16H12O6Pureza:98%Forma y color:Dark Brown Crystalline PowderPeso molecular:300.26ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:98.65%Forma y color:SoildPeso molecular:456.88Ref: TM-T23602
1mg172,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)354,00€Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Forma y color:LiquidPeso molecular:145.5 kDaHLY78
CAS:HLY78, a Wnt/β-catenin activator, enhances Axin-LRP6 binding by targeting Axin's DIX domain.Fórmula:C17H17NO2Pureza:99.58%Forma y color:SolidPeso molecular:267.32JW 67
CAS:JW 67 is an inhibitor of canonical Wnt pathway signaling.Fórmula:C21H18N2O6Pureza:97.02%Forma y color:SolidPeso molecular:394.38Ref: TM-T22884
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg273,00€50mg439,00€100mg647,00€1mL*10mM (DMSO)97,00€IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Fórmula:C22H17FN4O2S3Pureza:98.38%Forma y color:SolidPeso molecular:484.59Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFórmula:C25H26N6O2Pureza:97.21%Forma y color:SolidPeso molecular:442.51TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.75%Forma y color:SolidPeso molecular:371.39FH535
CAS:FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Forma y color:SolidPeso molecular:361.2Ref: TM-T2413
5mg38,00€10mg57,00€25mg94,00€50mg164,00€100mg274,00€200mg404,00€500mg653,00€1mL*10mM (DMSO)64,00€Miclxin
CAS:Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potentFórmula:C26H27N5O2Pureza:100% - 99.57%Forma y color:SolidPeso molecular:441.52Ref: TM-T73415
1mg64,00€5mg140,00€10mg192,00€25mg324,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)156,00€FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Forma y color:SolidPeso molecular:360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€Toxoflavin
CAS:Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.Fórmula:C7H7N5O2Pureza:98.24% - 99.7%Forma y color:SolidPeso molecular:193.16Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.Fórmula:C16H15ClN4O2Pureza:99.39%Forma y color:SolidPeso molecular:330.77Ref: TM-T9988
5mg74,00€10mg107,00€25mg216,00€50mg354,00€100mg567,00€200mg800,00€500mg1.198,00€1mL*10mM (DMSO)81,00€PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.Fórmula:C33H35N6O7PPureza:98.25% - 99.11%Forma y color:SoildPeso molecular:658.641(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Fórmula:C16H15FN4O2Pureza:99.61%Forma y color:SolidPeso molecular:314.31Ref: TM-T60803
1mg35,00€5mg70,00€10mg103,00€25mg182,00€50mg311,00€100mg512,00€200mg720,00€1mL*10mM (DMSO)81,00€IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Fórmula:C25H19N3O3Pureza:98.46% - 99.82%Forma y color:SolidPeso molecular:409.44WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.Fórmula:C22H23N3O3Pureza:99.57%Forma y color:SoildPeso molecular:377.44F7H
CAS:F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.Fórmula:C24H18FN3O2S2Pureza:99.85%Forma y color:SoildPeso molecular:463.55NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Fórmula:C20H11Cl2F3N2O4SPureza:99.50%Forma y color:SolidPeso molecular:503.28Gossypolone
CAS:Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Fórmula:C30H26O10Pureza:96.66%Forma y color:SolidPeso molecular:546.52TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Fórmula:C26H23N3O6Pureza:99.45%Forma y color:SoildPeso molecular:473.48KYA1797K
CAS:KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Fórmula:C17H11N2O6S2·KPureza:97.57% - 99.33%Forma y color:SolidPeso molecular:442.51N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
CAS:Macamide Impurity 14 promotes bone growth by activating Wnt/β-catenin, aiding osteoporosis study.Fórmula:C26H39NO2Pureza:98.66%Forma y color:SolidPeso molecular:397.59TNIK-IN-3
CAS:TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK).Fórmula:C23H18FN3O2Pureza:99.56%Forma y color:SolidPeso molecular:387.41Ref: TM-T9556
1mg106,00€5mg259,00€10mg406,00€25mg652,00€50mg938,00€100mg1.454,00€1mL*10mM (DMSO)284,00€ZW4864 free base
CAS:ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.Fórmula:C33H42N6O3Pureza:99.54%Forma y color:SolidPeso molecular:570.72Ref: TM-T9642
1mg160,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€iCRT 14
CAS:iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Fórmula:C21H17N3O2SPureza:98.85% - 99.8%Forma y color:SolidPeso molecular:375.44IQ 1
CAS:IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.Fórmula:C21H22N4O2Pureza:98.57% - ≥95%Forma y color:SolidPeso molecular:362.42Ref: TM-T3635
5mg51,00€10mg78,00€25mg140,00€50mg195,00€100mg350,00€200mg500,00€500mg810,00€1mL*10mM (DMSO)57,00€CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Fórmula:C19H15F3N4O2Pureza:99.74%Forma y color:SolidPeso molecular:388.34Ref: TM-T61742
1mg59,00€5mg127,00€10mg205,00€25mg454,00€50mg748,00€100mg1.054,00€200mg1.415,00€1mL*10mM (DMSO)139,00€YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:100%Forma y color:SoildPeso molecular:328.37LF3
CAS:LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Fórmula:C20H24N4O2S2Pureza:99.63%Forma y color:SolidPeso molecular:416.56SRI 37892
CAS:SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.Fórmula:C26H19N5O2SPureza:98.92%Forma y color:SolidPeso molecular:465.53Ref: TM-T9662
1mg378,00€5mg922,00€10mg1.225,00€25mg1.853,00€50mg2.490,00€100mg3.353,00€1mL*10mM (DMSO)1.074,00€FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Fórmula:C18H14N2O4Pureza:100%Forma y color:SolidPeso molecular:322.31Ref: TM-T15363
2mg42,00€5mg60,00€10mg96,00€25mg177,00€50mg283,00€100mg454,00€200mg653,00€1mL*10mM (DMSO)95,00€Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.01%Forma y color:SolidPeso molecular:456.92Carboxylesterase-IN-3
CAS:Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.Fórmula:C11H6Cl2N4OSPureza:97.49% - 97.89%Forma y color:SolidPeso molecular:313.16Nefopam hydrochloride
CAS:Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.Fórmula:C17H20ClNOPureza:99.32% - 99.85%Forma y color:SolidPeso molecular:289.8TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Fórmula:C24H24N4O3Pureza:99.4%Forma y color:SoildPeso molecular:416.47Ref: TM-T77660
1mg42,00€2mg52,00€5mg87,00€10mg127,00€25mg250,00€50mg373,00€100mg547,00€500mg1.159,00€Pyrvinium pamoate
CAS:Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFórmula:C26H28N3C23H14O6Pureza:100% - 98.43%Forma y color:SolidPeso molecular:575.71β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:98.78%Forma y color:SolidPeso molecular:255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€KY02111
CAS:KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Fórmula:C18H17ClN2O3SPureza:97.71%（96.56%） - 98.68%Forma y color:SolidPeso molecular:376.86Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Forma y color:SolidPeso molecular:588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:96.13%Forma y color:SolidPeso molecular:717.63Cardiogenol C
CAS:Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.Fórmula:C13H16N4O2Pureza:98.46%Forma y color:SolidPeso molecular:260.29EMT inhibitor-1
CAS:EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.Fórmula:C12H12Cl2N2O2SPureza:99%Forma y color:SolidPeso molecular:319.21Ref: TM-T11190
1mg111,00€5mg264,00€10mg424,00€25mg723,00€50mg1.008,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)283,00€exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44Ref: TM-T22775
5mg34,00€10mg52,00€25mg105,00€50mg173,00€100mg279,00€200mg406,00€1mL*10mM (DMSO)44,00€Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Forma y color:Liquidβ-catenin/CBP-IN-1
CAS:β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFórmula:C33H35N6O7PPureza:98%Forma y color:SolidPeso molecular:658.64
