Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Productos de "Células madre"
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AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Fórmula:C20H19N3O2Pureza:98.9%Forma y color:SolidPeso molecular:333.38Ref: TM-T22037
1mg52,00€5mg97,00€10mg170,00€25mg378,00€50mg560,00€100mg800,00€200mg1.103,00€1mL*10mM (DMSO)120,00€EMT inhibitor-1
CAS:EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.Fórmula:C12H12Cl2N2O2SPureza:99%Forma y color:SolidPeso molecular:319.21Ref: TM-T11190
1mg111,00€5mg264,00€10mg424,00€25mg723,00€50mg1.008,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)283,00€JAK-IN-27
CAS:JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nMFórmula:C20H21F2N7OPureza:98%Forma y color:SolidPeso molecular:413.42Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidSAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Fórmula:C28H30Cl3N3OSPureza:100%Forma y color:SoildPeso molecular:562.984-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:99.56%Forma y color:White To Beige SolidPeso molecular:233.49exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44Ref: TM-T22775
5mg34,00€10mg52,00€25mg105,00€50mg173,00€100mg279,00€200mg406,00€1mL*10mM (DMSO)44,00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Fórmula:C31H31F3N8O4Forma y color:SolidPeso molecular:639.64ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂,适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Forma y color:SolidPeso molecular:521.95MRK-560
CAS:MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.Fórmula:C19H17ClF5NO4S2Pureza:98.87%Forma y color:SolidPeso molecular:517.92ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Fórmula:C18H14N4OSPureza:98.53%Forma y color:SolidPeso molecular:334.39Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Fórmula:C95H128F3N25O28S3Pureza:99.48%Forma y color:SolidPeso molecular:2221.37Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Forma y color:SolidPeso molecular:754.83TTP 22
CAS:TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.Fórmula:C16H14N2O2S2Pureza:97.08% - 97.78%Forma y color:SolidPeso molecular:330.42Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.82%Forma y color:SolidPeso molecular:334.39Ref: TM-T9053
1mg73,00€5mg145,00€10mg220,00€25mg437,00€50mg567,00€100mg805,00€200mg1.111,00€1mL*10mM (DMSO)161,00€GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SForma y color:SolidPeso molecular:312.35Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Fórmula:C20H21N7OPureza:99.41%Forma y color:SolidPeso molecular:375.43CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent inhibitor of CK1, exhibiting IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a [1].Fórmula:C17H12FN3O2Pureza:98%Forma y color:SolidPeso molecular:309.29TEAD-IN-2
CAS:TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Fórmula:C16H18BrF3N2OForma y color:SolidPeso molecular:391.23JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Forma y color:SolidPeso molecular:521.59Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Fórmula:C27H41NO2Pureza:98.31% - 99.66%Forma y color:White Crystalline SolidPeso molecular:411.62BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.75%Forma y color:SolidPeso molecular:347.45Casein kinase 1δ-IN-4
CAS:"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."Fórmula:C16H12N6SPureza:98%Forma y color:SolidPeso molecular:320.37JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:96.69% - 99.15%Forma y color:SolidPeso molecular:344.45Ref: TM-T3042
2mg39,00€5mg57,00€10mg85,00€25mg157,00€50mg274,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)63,00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Fórmula:C24H40O2Pureza:99.89%Forma y color:SoildPeso molecular:360.57SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Forma y color:SolidPeso molecular:415.28P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Forma y color:SolidPeso molecular:1995.29Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Forma y color:LiquidDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Forma y color:LiquidPeso molecular:145.34 kDaDPP
CAS:DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstratingFórmula:C36H40Cl2N2O10PtPureza:98%Forma y color:SolidPeso molecular:926.7BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Fórmula:C26H26F4N4O3Forma y color:SolidPeso molecular:518.5Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Forma y color:LiquidAJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:≥98%Forma y color:SolidPeso molecular:526.51CSNK2-IN-2
CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.Fórmula:C25H30FN9OForma y color:SolidPeso molecular:491.56Casein kinase 1δ-IN-3
CAS:Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.Fórmula:C17H16N2O2SPureza:99.42%Forma y color:SoildPeso molecular:312.39Ref: TM-T64350
1mg38,00€5mg73,00€10mg115,00€25mg235,00€50mg373,00€100mg560,00€200mg797,00€1mL*10mM (DMSO)87,00€H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:98.42%Forma y color:SolidPeso molecular:392.34Ref: TM-T35328
1mg64,00€5mg142,00€10mg227,00€25mg439,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)156,00€MSC-5046
MSC-5046 is a selective inhibitor of TEAD1.Fórmula:C24H18F3N5O3Forma y color:SolidPeso molecular:481.43WAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.Fórmula:C11H12N2O2S2Pureza:99.43%Forma y color:SoildPeso molecular:268.36Ref: TM-T60067
1mg84,00€5mg163,00€10mg229,00€25mg379,00€50mg568,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)155,00€SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:99.13% - 99.61%Forma y color:SolidPeso molecular:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFórmula:C20H20ClN5OSPureza:98%Forma y color:SolidPeso molecular:413.92Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Fórmula:C14H8O4Pureza:98.43% - 99.61%Forma y color:SolidPeso molecular:240.21CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Fórmula:C19H15N3O2Pureza:96.14% - 98.21%Forma y color:SolidPeso molecular:317.34Ref: TM-T3684
1mg63,00€2mg86,00€5mg97,00€10mg155,00€25mg273,00€50mg462,00€100mg677,00€1mL*10mM (DMSO)81,00€GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:98.8%Forma y color:SolidPeso molecular:313.42Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:97.10% - 98.54%Forma y color:SolidPeso molecular:358.18Ref: TM-T3156
2mg42,00€5mg59,00€10mg85,00€25mg168,00€50mg235,00€100mg331,00€200mg492,00€1mL*10mM (DMSO)69,00€GNE-7883
CAS:GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Fórmula:C28H29FN6O2Pureza:97.61%Forma y color:SolidPeso molecular:500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€Aβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C35H49NPureza:99.14%Forma y color:SoildPeso molecular:483.77Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Forma y color:LiquidCMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:98.34% - 99.01%Forma y color:SolidPeso molecular:466.46JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.Fórmula:C20H24N6O2SPureza:98%Forma y color:SolidPeso molecular:412.51ROCK-IN-6
CAS:ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1Fórmula:C19H19N5O8SPureza:98%Forma y color:SolidPeso molecular:477.45Amcasertib
CAS:Amcasertib (BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways via targeting stemness kinases.Fórmula:C31H33N5O2SPureza:100% - 99.31%Forma y color:SolidPeso molecular:539.69Zelasudil
CAS:Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.Fórmula:C22H21F2N7OPureza:99.15%Forma y color:SolidPeso molecular:437.445Ref: TM-T69665
1mg92,00€5mg180,00€10mg274,00€25mg469,00€50mg653,00€100mg912,00€200mg1.225,00€1mL*10mM (DMSO)188,00€A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Fórmula:C17H13F3N4O2Pureza:99.78%Forma y color:SolidPeso molecular:362.31Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.51%Forma y color:SolidPeso molecular:352.5Ref: TM-T12721
1mg74,00€5mg145,00€10mg215,00€25mg378,00€50mg530,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)111,00€ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Forma y color:SolidPeso molecular:402.79Ref: TM-TQ0110
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€1mL*10mM (DMSO)373,00€SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Forma y color:SolidPeso molecular:286.29Ref: TM-T6989
5mg40,00€10mg60,00€25mg107,00€50mg185,00€100mg339,00€200mg510,00€500mg797,00€1mL*10mM (DMSO)66,00€HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Fórmula:C7H5N3O2Pureza:99.45% - 99.95%Forma y color:Off-White To Yellow SolidPeso molecular:163.13RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Fórmula:C16H14N4O2SPureza:98% - 99.73%Forma y color:SolidPeso molecular:326.37Ref: TM-T1898
5mg51,00€10mg87,00€25mg187,00€50mg311,00€100mg414,00€200mg520,00€500mg840,00€1mL*10mM (DMSO)57,00€BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFórmula:C14H13N3OSPureza:99.02%Forma y color:SolidPeso molecular:271.34Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Fórmula:C23H29ClO4Pureza:98%Forma y color:SolidPeso molecular:404.93CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.Fórmula:C31H43ClN4O5Pureza:95.22%Forma y color:SolidPeso molecular:587.15GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Fórmula:C22H15F2N5OPureza:98.77%Forma y color:SoildPeso molecular:403.38Ref: TM-T77341
1mg333,00€5mg922,00€10mg1.140,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg3.734,00€CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Fórmula:C15H18N2OPureza:99.44%Forma y color:SolidPeso molecular:242.32CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Forma y color:SolidPeso molecular:465.34Ref: TM-T2310
2mg43,00€5mg64,00€10mg96,00€25mg160,00€50mg254,00€100mg404,00€200mg603,00€500mg938,00€1mL*10mM (DMSO)70,00€FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Fórmula:C25H30N2O5Pureza:100% - ≥98%Forma y color:SolidPeso molecular:438.52Ref: TM-T3075
1mg35,00€2mg52,00€5mg74,00€10mg99,00€25mg172,00€50mg311,00€100mg542,00€500mg1.188,00€1mL*10mM (DMSO)82,00€JAK-IN-3
CAS:JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Fórmula:C18H20N4O3Pureza:98.04% - 98.19%Forma y color:SolidPeso molecular:340.38Ref: TM-T11704
1mg133,00€2mg188,00€5mg321,00€10mg518,00€25mg1.035,00€50mg1.644,00€100mg2.680,00€200mg3.591,00€1mL*10mM (DMSO)354,00€ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Fórmula:C15H15ClN2O4Pureza:99.35%Forma y color:SolidPeso molecular:322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€GSK3i XIII
CAS:GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Fórmula:C18H19N5Pureza:98.87%Forma y color:SolidPeso molecular:305.38Ref: TM-T24111
1mg99,00€5mg195,00€10mg293,00€25mg494,00€50mg715,00€100mg1.008,00€500mg2.015,00€1mL*10mM (DMSO)216,00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Fórmula:C22H14N4O3Pureza:99.42%Forma y color:SolidPeso molecular:382.37Ref: TM-T60160
5mg64,00€10mg92,00€25mg177,00€50mg283,00€100mg425,00€500mgA consultar1mL*10mM (DMSO)64,00€GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Fórmula:C18H12F3N3O2S2Forma y color:SolidPeso molecular:423.43LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Fórmula:C23H27N3O4Pureza:97.07%Forma y color:SolidPeso molecular:409.48Ref: TM-T9015
1mg38,00€5mg85,00€10mg118,00€25mg207,00€50mg306,00€100mg444,00€200mg622,00€1mL*10mM (DMSO)93,00€MF-Human S100B(S100 Calcium Binding Protein B) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human S100B. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human S100B. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human S100B, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human S100B. You can calculate the concentration of Human S100B in the samples by comparing the OD of the samples to the standard curve.Momelotinib Mesylate
CAS:Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Fórmula:C24H26N6O5SPureza:98%Forma y color:SolidPeso molecular:510.57LM-41
CAS:LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Fórmula:C19H14FNO2Pureza:99.73%Forma y color:SolidPeso molecular:307.32KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Fórmula:C14H10N4O3SPureza:99.66%Forma y color:SolidPeso molecular:314.32Ref: TM-T15677
2mg46,00€5mg80,00€10mg117,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)73,00€Mouse GDF10(GrowthDifferentiation Factor 10) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GDF10. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GDF10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GDF10, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GDF10 in the samples is then determined by comparing the OD of the samples to the standard curve.Forma y color:Colourless TransparentliquidNRX-252262
CAS:NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)Fórmula:C23H17Cl2F3N2O4SPureza:99.10% - 99.87%Forma y color:SolidPeso molecular:545.36Ref: TM-T9182
1mg114,00€5mg273,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)329,00€5-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFórmula:C16H10IN3O2Forma y color:SolidPeso molecular:403.17Y-27632
CAS:Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.Fórmula:C14H21N3OPureza:99.53% - 99.87%Forma y color:SolidPeso molecular:247.34Ref: TM-T1870
5mg47,00€10mg60,00€25mg97,00€50mg169,00€100mg274,00€200mg425,00€500mg702,00€1mL*10mM (DMSO)50,00€SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Forma y color:SolidPeso molecular:244.29MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Fórmula:C15H15NO4SPureza:99.76%Forma y color:SolidPeso molecular:305.35Ref: TM-T8710
1mg37,00€2mg49,00€5mg73,00€10mg119,00€25mg235,00€50mg354,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)82,00€ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFórmula:C20H18FN3OPureza:100%Forma y color:SolidPeso molecular:335.37CK2 inhibitor 2
CAS:CK2 Inhibitor 2, characterized as a potent, selective, and orally active inhibitor of CK2, demonstrates an impressive IC50 value of 0.66 nM.Fórmula:C21H17ClN4O2Pureza:99.09%Forma y color:SolidPeso molecular:392.84Ref: TM-T35557
1mg65,00€5mg145,00€10mg226,00€25mg449,00€50mg672,00€100mg900,00€200mg1.216,00€1mL*10mM (DMSO)160,00€TGFβ-IN-5
CAS:TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Fórmula:C20H16N4Pureza:99.29% - 99.5%Forma y color:SolidPeso molecular:312.37STAT3-IN-35
CAS:STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Fórmula:C21H23NO4Forma y color:SolidPeso molecular:353.41Casein kinase 1δ-IN-10
CAS:Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).Fórmula:C21H17N3O3Pureza:98%Forma y color:SolidPeso molecular:359.38MF-Rat cTnT/TNNT2(Troponin T Type 2, Cardiac) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat cTnT/TNNT2. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Rat cTnT/TNNT2. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat cTnT/TNNT2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Rat cTnT/TNNT2. You can calculate the concentration of Rat cTnT/TNNT2 in the samples by comparing the OD of the samples to the standard curve.GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Fórmula:C21H16F4N4O2Pureza:97.68% - 98.42%Forma y color:SolidPeso molecular:432.37GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.Fórmula:C9H6BrNOPureza:99.58%Forma y color:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05CP-352664
CAS:CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Fórmula:C18H18N4Forma y color:SolidPeso molecular:290.36LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Fórmula:C11H9ClN2O2S2Pureza:99.91%Forma y color:SolidPeso molecular:300.78PF-5274857
CAS:PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.Fórmula:C20H25ClN4O3SPureza:98.53%Forma y color:SolidPeso molecular:436.96CK1-IN-3
CAS:WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.Fórmula:C17H16N2O3SPureza:98.70%Forma y color:SolidPeso molecular:328.39Ref: TM-T60005
1mg48,00€5mg97,00€10mg145,00€25mg255,00€50mg368,00€100mg505,00€200mg692,00€1mL*10mM (DMSO)105,00€Mouse CC17(Clara Cell Protein) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CC17. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CC17. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse CC17, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CC17 in the samples is then determined by comparing the OD of the samples to the standard curve.Forma y color:Colourless TransparentliquidKaempferol 3-neohesperidoside
CAS:Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle.Fórmula:C27H30O15Pureza:98.34%Forma y color:SolidPeso molecular:594.52Ref: TM-TN1819
1mg62,00€5mg127,00€10mg187,00€25mg315,00€50mg472,00€100mg658,00€1mL*10mM (DMSO)166,00€GSK3-IN-4
CAS:GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.Fórmula:C18H20N4OPureza:97.1%Forma y color:SoildPeso molecular:308.38Ref: TM-T64366
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)153,00€CKI-7 free base
CAS:CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H12ClN3O2SForma y color:SolidPeso molecular:285.75GSK-3β inhibitor 20
CAS:GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.Fórmula:C22H21N5O2SForma y color:SolidPeso molecular:419.50
