Gamma-secretasa
Inhibidores de la gamma-secretasa son compuestos que se dirigen al complejo enzimático de la gamma-secretasa, involucrado en la escisión de la proteína precursora de amiloide (APP) para producir péptidos beta-amiloides. Estos péptidos pueden agregarse y formar placas amiloides, una característica distintiva de la enfermedad de Alzheimer. Al inhibir la gamma-secretasa, estos compuestos buscan reducir la producción de beta-amiloide y su acumulación en el cerebro, convirtiéndose en un enfoque clave en la investigación sobre la enfermedad de Alzheimer. En CymitQuimica, ofrecemos una selección de inhibidores de la gamma-secretasa para apoyar su investigación en biología del amiloide, terapia para el Alzheimer y enfermedades neurodegenerativas.
Productos de "Gamma-secretasa"
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ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Fórmula:C19H20BrClN2O3SPureza:99.73%Forma y color:SolidPeso molecular:471.8Ref: TM-T11178L
1mg162,00€5mg391,00€10mg615,00€25mg907,00€50mg1.235,00€100mg1.663,00€1mL*10mM (DMSO)447,00€γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Fórmula:C24H24N4OSPureza:99.48% - 99.75%Forma y color:SolidPeso molecular:416.54RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Fórmula:C25H28F3N7Pureza:98.63%Forma y color:SolidPeso molecular:483.532IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C13H11NO5S2Pureza:97.1% - 99.06%Forma y color:SolidPeso molecular:325.36γ-Secretase modulator 13
CAS:γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Fórmula:C22H23FN6SPureza:99.68%Forma y color:SolidPeso molecular:422.52CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFórmula:C17H20ClN3O2SPureza:99.02%Forma y color:SolidPeso molecular:365.88BI-1408
CAS:BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).Fórmula:C22H23FN6Pureza:99%Forma y color:SolidPeso molecular:390.46IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C15H15NO5S2Pureza:97.96% - 98.38%Forma y color:SolidPeso molecular:353.41CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Forma y color:SolidPeso molecular:329.42Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Pureza:> 95%Forma y color:LiquidPeso molecular:145.02 kDaAβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:100% - 99.49%Forma y color:SolidPeso molecular:430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Fórmula:C19H16N2O3Pureza:98.84%Forma y color:SolidPeso molecular:320.34JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Forma y color:SolidPeso molecular:364.44Brontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Forma y color:LiquidBMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Fórmula:C26H26F6N4O3Pureza:100% - 99.87%Forma y color:SolidPeso molecular:556.5γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Fórmula:C24H23FN4OSPureza:98%Forma y color:SolidPeso molecular:434.53JLK6
CAS:JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signallingFórmula:C10H8ClNO3Pureza:96.50%Forma y color:SolidPeso molecular:225.63Ref: TM-T21890
1mg131,00€5mg259,00€10mg371,00€25mg622,00€50mg885,00€100mg1.206,00€500mg2.403,00€1mL*10mM (DMSO)271,00€Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Fórmula:C23H25N5O4SPureza:98.14%Forma y color:SolidPeso molecular:467.54Demcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Forma y color:LiquidPeso molecular:145.34 kDaAβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C35H49NPureza:99.14%Forma y color:SoildPeso molecular:483.77
