Tirosina quinasa / adaptadores
Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.
Subcategorías de "Tirosina quinasa / adaptadores"
- ALK
- c-Fms
- c-Kit
- c-Met / HGFR
- c-RET
- CSF-1R
- EGFR
- Receptor de efrina
- Receptor del factor de crecimiento de fibroblastos (FGFR)
- FLT
- Hck
- HER
- IGF-1R
- PDGFR
- PYK2
- Src
- Receptor TAM
- Tie-2
- Receptor de Trk
- Tirosina quinasas
- VEGFR
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Productos de "Tirosina quinasa / adaptadores"
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Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Fórmula:C18H22FN9O2Pureza:100%Forma y color:SolidPeso molecular:415.42ACP-5862
CAS:ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Fórmula:C26H23N7O3Forma y color:SolidPeso molecular:481.51Duligotuzumab
CAS:Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody targeting Her3 (ErbB3) [1].Pureza:98%Forma y color:LiquidLumretuzumab
CAS:Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Forma y color:LiquidXL092
CAS:XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.Fórmula:C29H25FN4O5Pureza:98.60%Forma y color:SolidPeso molecular:528.53LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Fórmula:C25H22N6Pureza:98% - 98.71%Forma y color:SolidPeso molecular:406.48EGFR-IN-82
CAS:EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/Fórmula:C32H41BrN9O2PPureza:98%Forma y color:SolidPeso molecular:694.6Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Fórmula:C31H39N7O5SPureza:98.85%Forma y color:SolidPeso molecular:621.75Ref: TM-T9865
1mg55,00€5mg116,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg840,00€1mL*10mM (DMSO)170,00€LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Fórmula:C16H16ClN3O2Pureza:99.89%Forma y color:SolidPeso molecular:317.77AG 1478 Hydrochloride
CAS:Fórmula:C16H14ClN3O2·HClPureza:>95.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:352.22EGFR-IN-126
CAS:EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Fórmula:C28H28BrFN4O3Forma y color:SolidPeso molecular:567.45Ddr1-In-1
CAS:DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.Fórmula:C30H31F3N4O3Pureza:99.34% - 99.84%Forma y color:SolidPeso molecular:552.59Ref: TM-T3337
1mg42,00€2mg52,00€5mg85,00€10mg115,00€25mg170,00€50mg227,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)90,00€EGFR-IN-87
CAS:EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,Fórmula:C28H33N7O2Pureza:98.64%Forma y color:SolidPeso molecular:499.61AZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Forma y color:SolidPeso molecular:463.57Ref: TM-T1948
2mg39,00€5mg49,00€10mg63,00€25mg88,00€50mg113,00€100mg156,00€200mg219,00€500mg366,00€1mL*10mM (DMSO)55,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:419.48Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Forma y color:SolidPeso molecular:445.54Ref: TM-T2487
1mg44,00€2mg55,00€5mg79,00€10mg106,00€25mg185,00€50mg283,00€100mg432,00€200mg605,00€500mg938,00€1mL*10mM (DMSO)86,00€LDC1267
CAS:LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).Fórmula:C30H26F2N4O5Pureza:99.38% - 99.76%Forma y color:SolidPeso molecular:560.55Ref: TM-T2311
1mg35,00€2mg52,00€5mg77,00€10mg105,00€25mg168,00€50mg248,00€100mg419,00€1mL*10mM (DMSO)93,00€DDR1-IN-4
CAS:DDR1-IN-4 is a DDR1 inhibitor that inhibits autophosphorylation of DDR1 and DDR2 and can be used to study chronic kidney disease.Fórmula:C23H20BrF3N6O3Pureza:97.25%Forma y color:SolidPeso molecular:565.34Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Fórmula:C25H32N8OPureza:99.28%Forma y color:SolidPeso molecular:460.57Ref: TM-T6081
1mg51,00€5mg106,00€10mg177,00€25mg376,00€50mg603,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)110,00€
