Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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Recifercept
CAS:Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.Forma y color:LiquidFGFR-IN-11
CAS:FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Fórmula:C28H29ClN4O4Pureza:98%Forma y color:SolidPeso molecular:521.01FGFR1 inhibitor-8
FGFR1 inhibitor-8 (Compound 9), an FGFR1 inhibitor with an IC50 of 0.5 nM, binds to the ATP-binding pocket of FGFR1 and exhibits anticancer activity [1].Fórmula:C26H18ClNO5Pureza:98%Forma y color:SolidPeso molecular:459.88BLU9931
CAS:BLU9931 is the first selective small molecule inhibitor of FGFR4.Fórmula:C26H22Cl2N4O3Pureza:96.958% - 99.85%Forma y color:SolidPeso molecular:509.38Regorafenib
CAS:Fórmula:C21H15ClF4N4O3Pureza:>98.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:482.82FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Fórmula:C28H32Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:603.5EOC317
CAS:EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Fórmula:C27H26F5N7O3Pureza:98.00% - 99.26%Forma y color:SolidPeso molecular:591.53Ref: TM-T4318
1mg117,00€2mg172,00€5mg248,00€10mg418,00€25mgA consultar50mgA consultar100mgA consultar1mL*10mM (DMSO)324,00€Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Fórmula:C31H33N5O4Pureza:98% - 99.92%Forma y color:SolidPeso molecular:539.62LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Fórmula:C21H19Cl2N5O2Pureza:97.22% - 99.46%Forma y color:SolidPeso molecular:444.31Ref: TM-T2361
1mg52,00€5mg97,00€10mg160,00€25mg313,00€50mg494,00€100mg742,00€200mg1.008,00€1mL*10mM (DMSO)111,00€U3-1784
U3-1784 is a humanized monoclonal antibody targeting CD334, with anti-cancer activity, used in liver cancer research.Forma y color:LiquidPeso molecular:145.5AZ8010
CAS:AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.Fórmula:C27H34N4O3Forma y color:SolidPeso molecular:462.58S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Fórmula:C22H22N4O4SPureza:95.35% - 97.4%Forma y color:SolidPeso molecular:438.5Ref: TM-T3274
1mg47,00€2mg63,00€5mg84,00€10mg96,00€25mg170,00€50mg305,00€100mg558,00€1mL*10mM (DMSO)92,00€Efimosfermin alfa
Efimosfermin alfa is a humanized antibody targeting FGFR1.Forma y color:Odour LiquidASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Fórmula:C18H19F2N5O4Pureza:99.8% - 99.86%Forma y color:SolidPeso molecular:407.37Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Fórmula:C28H30N6OSPureza:100% - 99.55%Forma y color:SolidPeso molecular:498.64Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFórmula:C29H27F3N6OPureza:98% - 99.60%Forma y color:SolidPeso molecular:532.56NSC 12
CAS:NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.Fórmula:C24H34F6O3Pureza:99.51%Forma y color:SolidPeso molecular:484.52Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
CAS:Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist.Fórmula:C26H32N4O8Pureza:100% - 99.83%Forma y color:SolidPeso molecular:528.55SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Fórmula:C26H37N5O2Pureza:98.43%Forma y color:SolidPeso molecular:451.6Lenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Fórmula:C21H19ClN4O4Pureza:98.46% - 99.8000%Forma y color:SolidPeso molecular:426.85ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.22% - 99.53%Forma y color:SolidPeso molecular:429.52Derazantinib
CAS:Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C29H29FN4OPureza:99.71%Forma y color:SolidPeso molecular:468.57Ref: TM-TQ0228
1mg52,00€5mg116,00€10mg169,00€25mg271,00€50mg401,00€100mg597,00€200mg850,00€1mL*10mM (DMSO)125,00€Irpagratinib
CAS:Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.Fórmula:C28H32F2N6O5Pureza:99.08%Forma y color:SolidPeso molecular:570.59Ref: TM-T79850
1mg98,00€5mg232,00€10mg373,00€25mg737,00€50mg1.175,00€100mg1.824,00€200mg2.441,00€1mL*10mM (DMSO)291,00€Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Forma y color:SolidPeso molecular:503.38Ref: TM-T3456
1mg52,00€5mg120,00€10mg177,00€25mg310,00€50mg469,00€100mg707,00€500mg1.415,00€1mL*10mM (DMSO)134,00€Sucralfate
CAS:Sucralfate (Sucrose octasulfate-aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of activeFórmula:C12H54Al16O75S8Pureza:98%Forma y color:White Amorphous PowderPeso molecular:2086.75SM27
CAS:SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.Fórmula:C21H16N2O9S2Pureza:98.83%Forma y color:SolidPeso molecular:504.49TG 100572 Hydrochloride
CAS:TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Fórmula:C26H27Cl2N5O2Pureza:98%Forma y color:SolidPeso molecular:512.43H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Fórmula:C29H34Cl2N8O4Pureza:97.45%Forma y color:SolidPeso molecular:629.54Ref: TM-T7738
1mg70,00€5mg169,00€10mg274,00€25mg530,00€50mg748,00€100mg1.064,00€1mL*10mM (DMSO)283,00€ODM-203
CAS:ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor ImmunityFórmula:C26H21F2N5O2SPureza:99.85%Forma y color:SolidPeso molecular:505.54FIIN-4
CAS:FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.Fórmula:C35H38N8O4Pureza:100%Forma y color:SolidPeso molecular:634.73GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98Ref: TM-T6930
10mg52,00€25mg90,00€50mg96,00€100mg140,00€200mg229,00€500mg359,00€1mL*10mM (DMSO)52,00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Fórmula:C26H30N6O3Pureza:97.88% - 98.44%Forma y color:White PowderPeso molecular:474.55Ref: TM-T2094
1mg59,00€2mg85,00€5mg116,00€10mg188,00€25mg365,00€50mg555,00€100mg795,00€500mg1.605,00€1mL*10mM (DMSO)120,00€FGFR1 inhibitor-17
CAS:FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.Fórmula:C16H13ClN2O3Forma y color:SolidPeso molecular:316.739ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47Ref: TM-T2358
1mg51,00€2mg72,00€5mg105,00€10mg159,00€25mg279,00€50mg462,00€100mg648,00€1mL*10mM (DMSO)116,00€2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS:Fórmula:C21H15ClF4N4O3Pureza:98%Forma y color:SolidPeso molecular:482.8154Ref: IN-DA00ICN3
1g131,00€5g255,00€10g619,00€25gA consultar10mg30,00€50mg46,00€100mg56,00€250mg69,00€500mg100,00€PROTAC FGFR1 degrader-1
PROTAC FGFR1 degrader-1 (compound S2H) is a targeted degrader of FGFR1, demonstrating an IC50 of 26.81 nM and a DC50 of 39.78 nM in KG1a cells. This compound is composed of a CRBN-type E3 ligase ligand (blue part) Pomalidomide, a target protein ligand (red part) FGFR1ligand-1, and a PROTAC linker (black part) 9-Bromononanoic acid, together forming the conjugate E3LigaseLigand-linker Conjugate 164.Fórmula:C46H54N8O8Forma y color:SolidPeso molecular:846.97Surfen dihydrochloride
CAS:Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a heparin sulfate antagonist with antimicrobial properties and inhibits blockade of signaling.Fórmula:C21H22Cl2N6OPureza:97.08%Forma y color:SolidPeso molecular:445.35PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:96.78%Forma y color:SolidPeso molecular:405.28Fanregratinib
CAS:Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.Fórmula:C27H33ClN6O2Forma y color:SolidPeso molecular:509.04FGFR4-IN-14
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutantFórmula:C27H25Cl2N5O2Pureza:98%Forma y color:SolidPeso molecular:522.43FGFR-IN-16
CAS:FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.Fórmula:C30H27Cl2N7O4Forma y color:SolidPeso molecular:620.49Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Fórmula:C29H34N6O4S2Pureza:100% - 97.67%Forma y color:SolidPeso molecular:594.75Ref: TM-T8544
5mg35,00€10mg51,00€25mg77,00€50mg95,00€100mg144,00€200mg225,00€500mg373,00€1mL*10mM (DMSO)49,00€SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Fórmula:C18H16N2O4Pureza:98%Forma y color:SolidPeso molecular:324.33Bemarituzumab
CAS:Bemarituzumab: humanized IgG1 antibody inhibits FGFR2b, may be used in cancer research.Pureza:SDS-PAGE:95% SEC-HPLC:99.99%Forma y color:LiquidPeso molecular:144 kDaFGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Fórmula:C23H22N4OPureza:98.09%Forma y color:SolidPeso molecular:370.45PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Fórmula:C28H35N7O2Pureza:98.20%Forma y color:SolidPeso molecular:501.62PD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Fórmula:C28H41N7O3Pureza:98.15% - 98.21%Forma y color:Yellow SolidPeso molecular:523.67Ref: TM-T2642
5mg43,00€10mg57,00€25mg89,00€50mg140,00€100mg221,00€200mg393,00€500mg655,00€1mL*10mM (DMSO)59,00€Ferulic acid sodium
CAS:Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.Fórmula:C10H9NaO4Pureza:99.58%Forma y color:White Crystalline PowderPeso molecular:216.16FGFR4-IN-1
CAS:FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).Fórmula:C24H27N7O5Pureza:98.96%Forma y color:SolidPeso molecular:493.52FGFR1/DDR2 inhibitor 1
CAS:FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108Fórmula:C28H22F3N5OPureza:99.43%Forma y color:SolidPeso molecular:501.5Ref: TM-T11279
1mg92,00€5mg216,00€10mg354,00€25mg582,00€50mg802,00€100mg1.169,00€1mL*10mM (DMSO)240,00€CP-547632 hydrochloride
CAS:CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.Fórmula:C20H25BrClF2N5O3SForma y color:SolidPeso molecular:568.86KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.89%Forma y color:SolidPeso molecular:332.4FGFR2/3-IN-2
CAS:FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.Fórmula:C29H23FN6O3Forma y color:SolidPeso molecular:522.53DGY-06-116
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.Fórmula:C32H33ClN8O2Pureza:97.65%Forma y color:SolidPeso molecular:597.11Ref: TM-T22306
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)70,00€SSR128129E
CAS:SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.Fórmula:C18H15N2O4·NaPureza:98.79% - ≥95%Forma y color:SolidPeso molecular:346.31PD 173074
CAS:Fórmula:C28H41N7O3Pureza:>95.0%(HPLC)Forma y color:White to Yellow to Orange powder to crystalPeso molecular:523.68FIIN-1
CAS:FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,Fórmula:C32H39Cl2N7O4Pureza:97.30%Forma y color:SolidPeso molecular:656.6Ref: TM-T37426
1mg79,00€2mg103,00€5mg202,00€10mg329,00€25mg550,00€50mg783,00€100mg1.035,00€500mg2.118,00€PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Fórmula:C26H30Cl2N6O4Pureza:98.65%Forma y color:SolidPeso molecular:561.46Ref: TM-TQ0015
1mg81,00€2mg105,00€5mg170,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)212,00€Aprutumab
CAS:Aprutumab, a human FGFR2 monoclonal antibody, targets FGFR2-IIIB/C and is used in antibody-drug conjugates.Pureza:98.69% (SEC-HPLC) - 98.69% (SEC-HPLC)Forma y color:LiquidPeso molecular:150 kDaR1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Fórmula:C18H14ClFN4OPureza:97.96%Forma y color:SolidPeso molecular:356.78TYRA-300
CAS:TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.Fórmula:C25H24Cl2N6O3SPureza:99.66%Forma y color:SolidPeso molecular:559.47Ref: TM-T88841
1mg404,00€5mg735,00€10mg999,00€25mg1.588,00€50mg2.147,00€100mg2.902,00€1mL*10mM (DMSO)904,00€KHS101 hydrochloride
CAS:KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.Fórmula:C18H22ClN5SPureza:99.6%Forma y color:SolidPeso molecular:375.92Ref: TM-T5170
2mg37,00€5mg55,00€10mg85,00€25mg156,00€50mg251,00€100mg369,00€200mg525,00€1mL*10mM (DMSO)62,00€PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.23%Forma y color:SolidPeso molecular:532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€Pazopanib
CAS:Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.Fórmula:C21H23N7O2SPureza:98.78% - 99.72%Forma y color:White PowderPeso molecular:437.52Ref: TM-T0097L
10mg49,00€25mg73,00€50mg96,00€100mg145,00€200mg236,00€500mg331,00€1mL*10mM (DMSO)59,00€BW710
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.Fórmula:C28H29FN6O2SForma y color:SolidPeso molecular:532.63XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively)Fórmula:C26H28FN5OPureza:98.24% - 99.55%Forma y color:SolidPeso molecular:445.53FGFR4-IN-16
CAS:FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].Fórmula:C35H30Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:685.56Rogaratinib
CAS:Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Fórmula:C23H26N6O3SPureza:99.54%Forma y color:SolidPeso molecular:466.56FGFR2-IN-3
CAS:FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].Fórmula:C28H24FN7O2Pureza:99.24%Forma y color:SoildPeso molecular:509.53Ref: TM-T60185
1mg95,00€5mg202,00€10mg298,00€25mg630,00€50mg938,00€100mg1.264,00€1mL*10mM (DMSO)224,00€Orantinib
CAS:Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Fórmula:C18H18N2O3Pureza:100% - 98.01%Forma y color:SolidPeso molecular:310.35Pemigatinib
CAS:Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).Fórmula:C24H27F2N5O4Pureza:98.15% - 99.95%Forma y color:SolidPeso molecular:487.5LC-MB12
CAS:LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.Fórmula:C43H44Cl2N10O8Pureza:99.16%Forma y color:SolidPeso molecular:899.78S49076 HCl
CAS:S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.Fórmula:C22H18ClN3O5Pureza:98%Forma y color:SolidPeso molecular:439.85Infigratinib phosphate
CAS:Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Forma y color:SolidPeso molecular:658.47Dovitinib
CAS:Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.Fórmula:C21H21FN6OPureza:99.66% - 99.78%Forma y color:SolidPeso molecular:392.43Ref: TM-T6289
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg328,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)50,00€Gunagratinib
CAS:Gunagratinib (ICP-192) is a pan-FGFR inhibitor, useful in research on FGFR-related diseases.Fórmula:C22H25N5O4Pureza:99.68%Forma y color:SolidPeso molecular:423.47BO-264
CAS:BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Fórmula:C18H19N5O3Pureza:98.03% - 99.81%Forma y color:SolidPeso molecular:353.38CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.41%Forma y color:SolidPeso molecular:486.31Lucitanib
CAS:Lucitanib (E-3810) is a VEGFR/FGFR inhibitor targeting VEGFR1-3 and FGFR1-2 with IC50s 7-82.5 nM.Fórmula:C26H25N3O4Pureza:96.13%Forma y color:SolidPeso molecular:443.49Ref: TM-T15185
1mg48,00€2mg63,00€5mg87,00€10mg144,00€25mg269,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)96,00€FGFR3-IN-7
CAS:FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H24FN9OPureza:98%Forma y color:SolidPeso molecular:485.52SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Forma y color:Yellow-Green SolidPeso molecular:296.32Fazpilodemab
CAS:Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ.Pureza:98%Forma y color:LiquidAZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Forma y color:SolidPeso molecular:463.57Ref: TM-T1948
2mg39,00€5mg49,00€10mg63,00€25mg88,00€50mg113,00€100mg156,00€200mg219,00€500mg366,00€1mL*10mM (DMSO)55,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:419.48FGFR1 inhibitor-9
FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM.Fórmula:C27H20ClNO5Pureza:98%Forma y color:SolidPeso molecular:473.9Infigratinib
CAS:Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFórmula:C26H31Cl2N7O3Pureza:98% - 98.97%Forma y color:SolidPeso molecular:560.48FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Fórmula:C22H23N5O5SForma y color:SolidPeso molecular:469.51Heparan Sulfate
CAS:Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.Fórmula:C12H19NO20S3(monomer)Pureza:98%Forma y color:SolidPeso molecular:593.47(monomer)SU4984
CAS:SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Fórmula:C20H19N3O2Pureza:100%Forma y color:SolidPeso molecular:333.38FGFR1 inhibitor-10
CAS:FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.Fórmula:C26H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:561.62PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.7%Forma y color:SolidPeso molecular:369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€PP58
CAS:PP58 is an inhibitor of PDGFR, FGFR and Src family.Fórmula:C22H19Cl2N5O2Pureza:99.21%Forma y color:SolidPeso molecular:456.32FGFR1 inhibitor 7
FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrumFórmula:C25H16ClNO4Pureza:98%Forma y color:SolidPeso molecular:429.85PD-161570
CAS:Fórmula:C26H35Cl2N7OPureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:532.51FGFR3-IN-6
CAS:FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H23FN8O2Pureza:98%Forma y color:SolidPeso molecular:486.5FGFR1 inhibitor-16
CAS:FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Fórmula:C16H9N5O3SForma y color:SolidPeso molecular:351.339Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Fórmula:C24H27FN6O4Pureza:99.82%Forma y color:SolidPeso molecular:482.51Roblitinib
CAS:Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Fórmula:C25H30N8O4Pureza:97.27% - 99%Forma y color:SolidPeso molecular:506.56Ref: TM-T4235
1mg58,00€2mg84,00€5mg103,00€10mg169,00€25mg306,00€50mg535,00€100mg752,00€500mg1.586,00€Nintedanib
CAS:Fórmula:C31H33N5O4Pureza:>95.0%(T)(HPLC)Forma y color:White to Yellow to Yellow green powder to crystalPeso molecular:539.64
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