Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Productos de "Receptor de Trk"
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Tepotinib
CAS:Tepotinib (EMD-1214063) is a selective, orally, and ATP-competitive c-MET tyrosine kinase inhibitor. Tepotinib has antitumor effect. Cost-effective and quality-assured.Fórmula:C29H28N6O2Pureza:98% - 99.91%Forma y color:SolidPeso molecular:492.57Ref: TM-T6121
1mg42,00€2mg55,00€5mg88,00€10mg127,00€25mg235,00€50mg395,00€100mg558,00€200mg810,00€1mL*10mM (DMSO)96,00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Fórmula:C33H44FN5O3Pureza:99.33% - 99.44%Forma y color:SolidPeso molecular:577.73Ref: TM-T4257
1mg43,00€2mg57,00€5mg87,00€10mg140,00€25mg274,00€50mg378,00€100mg528,00€1mL*10mM (DMSO)111,00€7,8-Dihydroxyflavone
CAS:7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.Fórmula:C15H10O4Pureza:98.37% - 99.81%Forma y color:SolidPeso molecular:254.24Trk-IN-4
CAS:Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).Fórmula:C24H23F4N5O4Pureza:98%Forma y color:SolidPeso molecular:521.46ONO-7579
CAS:ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.Fórmula:C24H18ClF3N6O4SForma y color:SolidPeso molecular:578.95Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Fórmula:C25H32N8OPureza:99.28%Forma y color:SolidPeso molecular:460.57Ref: TM-T6081
1mg51,00€5mg106,00€10mg177,00€25mg376,00€50mg603,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)110,00€Tavilermide
CAS:Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Fórmula:C24H32N6O11Pureza:98.98%Forma y color:SolidPeso molecular:580.54Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFórmula:C26H29Cl4FN6O3Pureza:98.73%Forma y color:SolidPeso molecular:634.36Ref: TM-T22324
1mg66,00€2mg93,00€5mg144,00€10mg227,00€25mg464,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)188,00€N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Fórmula:C12H14N2O2Pureza:98.03% - 99.91%Forma y color:SolidPeso molecular:218.25TRK-IN-24
CAS:TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,Fórmula:C39H45N7O3Pureza:98%Forma y color:SolidPeso molecular:659.82GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Fórmula:C25H27ClFN7Pureza:99.44%Forma y color:SolidPeso molecular:479.98AZ-23
CAS:AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.Fórmula:C17H19ClFN7OPureza:99.4%Forma y color:SolidPeso molecular:391.83
