Src
Los inhibidores de Src son compuestos que se dirigen a las quinasas de la familia Src, que están involucradas en diversos procesos celulares, como el crecimiento, la diferenciación y la angiogénesis. Las quinasas Src desempeñan un papel crucial en las vías de señalización que promueven la formación de nuevos vasos sanguíneos en los tumores. Inhibir Src puede interrumpir estas vías, reduciendo así la angiogénesis y el crecimiento tumoral. Los inhibidores de Src se utilizan ampliamente en la investigación del cáncer y en el desarrollo terapéutico. En CymitQuimica, ofrecemos una selección completa de inhibidores de Src de alta calidad para apoyar su investigación en oncología, señalización celular y angiogénesis.
Productos de "Src"
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Scutellarein
CAS:Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.Fórmula:C15H10O6Pureza:98.02% - 99.63%Forma y color:SolidPeso molecular:286.24A 419259
CAS:A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn).Fórmula:C29H34N6OForma y color:SolidPeso molecular:482.62AZ12672857
CAS:AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM.Fórmula:C26H30N8O2Pureza:98.05%Forma y color:SolidPeso molecular:486.57Ref: TM-T9650
1mg70,00€2mg93,00€5mg155,00€10mg259,00€25mg424,00€50mg662,00€100mg894,00€1mL*10mM (DMSO)166,00€UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Forma y color:SolidPeso molecular:640.68SU6656
CAS:SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Fórmula:C19H21N3O3SPureza:97% - 98.21%Forma y color:SolidPeso molecular:371.45Ref: TM-T6997
1mg40,00€2mg51,00€5mg85,00€10mg139,00€25mg269,00€50mg449,00€100mg667,00€1mL*10mM (DMSO)88,00€lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Fórmula:C14H13NO5Pureza:97.77%Forma y color:Yellow To Tan PowderPeso molecular:275.26Ref: TM-T4185
1mg44,00€2mg58,00€5mg87,00€10mg160,00€25mg349,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)95,00€Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFórmula:C25H28O6Pureza:99.94% - ≥98%Forma y color:SolidPeso molecular:424.49PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.23%Forma y color:SolidPeso molecular:532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€CH6953755
CAS:CH6953755: oral YES1 kinase inhibitor, IC50 1.8 nM, potent, selective, anticancer, halts cell proliferation.Fórmula:C26H22F2N6O4SPureza:98.03%Forma y color:SolidPeso molecular:552.55Ref: TM-T10784
1mg58,00€5mg123,00€10mg187,00€25mg366,00€50mg588,00€100mg944,00€1mL*10mM (DMSO)149,00€CSF1R-IN-2
CAS:CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Fórmula:C20H20FN7O2Pureza:99.29%Forma y color:SolidPeso molecular:409.42Bafetinib
CAS:Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Forma y color:SolidPeso molecular:576.62Ref: TM-T6311
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg159,00€50mg188,00€100mg350,00€200mg455,00€1mL*10mM (DMSO)90,00€TGF-βRI inhibitor 3
CAS:TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.396PP 3
CAS:PP 3 is a Negative control for the Src kinase inhibitor PP 2Fórmula:C11H9N5Pureza:98.61%Forma y color:Whit To Off-White SolidPeso molecular:211.22Ref: TM-T23176
5mg51,00€10mg79,00€25mg140,00€50mg202,00€100mg305,00€500mg733,00€1mL*10mM (DMSO)55,00€Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Fórmula:C26H29Cl2N5O3Pureza:98.98% - 99.9%Forma y color:Yellowish-Orange Or Pink To Brownish Solid Solid PowderPeso molecular:530.45OXSI-2
CAS:OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.Fórmula:C18H15N3O3SPureza:98%Forma y color:Dark Orange SolidPeso molecular:353.391-Naphthyl PP1
CAS:1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)Fórmula:C19H19N5Pureza:99.85%Forma y color:White Cyrstalline SolidPeso molecular:317.39PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:419.48BT424
CAS:BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].Fórmula:C22H15BCl2N2O2Pureza:98%Forma y color:SolidPeso molecular:421.08WHI-P154
CAS:Fórmula:C16H14BrN3O3Pureza:>98.0%(HPLC)Forma y color:White to Yellow to Orange powder to crystalPeso molecular:376.21Tolimidone
CAS:Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.Fórmula:C11H10N2O2Pureza:99.85% - 99.85%Forma y color:SolidPeso molecular:202.21TL02-59 dihydrochloride
CAS:TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).Fórmula:C32H36Cl2F3N5O4Pureza:98%Forma y color:SolidPeso molecular:682.56A-770041
CAS:A-770041 is an Lck inhibitor, YZ inhibits the production of IL-2 stimulated by concanavalin A in whole blood, and can prevent cardiac allograft rejection.Fórmula:C34H39N9O3Pureza:99.23% - 99.86%Forma y color:SolidPeso molecular:621.73Ref: TM-T14074
1mg55,00€5mg116,00€10mg188,00€25mg426,00€50mg725,00€100mg1.130,00€200mg1.501,00€1mL*10mM (DMSO)159,00€A 419259 trihydrochloride
CAS:A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).Fórmula:C29H37Cl3N6OPureza:100% - 99.47%Forma y color:SolidPeso molecular:592Ref: TM-TQ0132
1mg52,00€2mg74,00€5mg107,00€10mg170,00€25mg319,00€50mg557,00€100mg797,00€500mg1.586,00€GluR6 antagonist-1
CAS:GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.Fórmula:C15H11ClN2OSPureza:98.07%Forma y color:SolidPeso molecular:302.78Ref: TM-T9723
2mg38,00€5mg58,00€10mg90,00€25mg138,00€50mg197,00€100mg294,00€200mg411,00€1mL*10mM (DMSO)65,00€KX1-004
CAS:KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.Fórmula:C16H13FN2O2Pureza:99.12% - ≥95%Forma y color:SolidPeso molecular:284.29Ref: TM-T1812
1mg46,00€2mg59,00€5mg87,00€10mg160,00€25mg283,00€50mg465,00€100mg655,00€500mg1.378,00€1mL*10mM (DMSO)97,00€Dasatinib monohydrate
CAS:Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Fórmula:C22H28ClN7O3SPureza:100% - 99.68%Forma y color:SolidPeso molecular:506.03Src Inhibitor 1
CAS:Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.Fórmula:C22H19N3O3Pureza:100% - 99.38%Forma y color:SolidPeso molecular:373.4MCB-613
CAS:MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.Fórmula:C20H20N2OPureza:98.17% - 99.33%Forma y color:SolidPeso molecular:304.39Ref: TM-T6886
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg259,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)96,00€1-Naphthyl PP1 hydrochloride
CAS:1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-SrcFórmula:C19H20ClN5Pureza:98.63%Forma y color:SolidPeso molecular:353.85NVP-BHG 712
CAS:Fórmula:C26H20F3N7OPureza:>95.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:503.49SI-2 hydrochloride
CAS:SI-2 hydrochloride, an SRC-3 inhibitor, induces breast cancer cell death (IC50: 3-20 nM) with good oral bioavailability.Fórmula:C15H16ClN5Pureza:98.18%Forma y color:SolidPeso molecular:301.771-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Fórmula:C20H21N5Pureza:98% - 98.93%Forma y color:White Cyrstalline SolidPeso molecular:331.41Ref: TM-T2153
1mg50,00€2mg66,00€5mg88,00€10mg139,00€25mg286,00€50mg532,00€100mg705,00€1mL*10mM (DMSO)95,00€Rebastinib
CAS:DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,Fórmula:C30H28FN7O3Pureza:99.53% - 99.79%Forma y color:SolidPeso molecular:553.59PP 2
CAS:Fórmula:C15H16ClN5Pureza:>97.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:301.78AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Fórmula:C29H28F3N5O2Pureza:98%Forma y color:SolidPeso molecular:535.56Adrenalone hydrochloride
CAS:Adrenalone HCl: α1-adrenoceptor agonist, topical hemostatic, vasoconstrictor, prolongs local anesthesia.Fórmula:C9H11NO3·HClPureza:99.94%Forma y color:SolidPeso molecular:217.65Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Forma y color:SolidPeso molecular:596.64PP2
CAS:PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.Fórmula:C15H16ClN5Pureza:95.65% - 98%Forma y color:White SolidPeso molecular:301.77Ref: TM-T6266
2mg47,00€5mg69,00€10mg116,00€25mg188,00€50mg321,00€100mg510,00€200mg725,00€1mL*10mM (DMSO)74,00€PP 1
CAS:Fórmula:C16H19N5Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:281.36Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Fórmula:C22H26ClN7O2SPureza:99.59% - 99.86%Forma y color:Pale-Yellow SolidPeso molecular:488.01TL02-59
CAS:TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.Fórmula:C32H34F3N5O4Pureza:95.63%Forma y color:SolidPeso molecular:609.64Ref: TM-T13186
1mg71,00€5mg135,00€10mg212,00€25mg359,00€50mg512,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)170,00€Bosutinib
CAS:Fórmula:C26H29Cl2N5O3Pureza:>95.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:530.45Dasatinib
CAS:Fórmula:C22H26ClN7O2SPureza:>95.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:488.01PD173955
CAS:PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFórmula:C21H16Cl2N4OSPureza:98.52% - 99.28%Forma y color:SolidPeso molecular:443.35RK-24466
CAS:RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.Fórmula:C23H22N4OPureza:98.07%Forma y color:SolidPeso molecular:370.45Ref: TM-T16760
1mg66,00€5mg144,00€10mg227,00€25mg393,00€50mg588,00€100mg905,00€1mL*10mM (DMSO)159,00€Tirbanibulin Mesylate
CAS:Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Fórmula:C27H33N3O6SPureza:99.42%Forma y color:SolidPeso molecular:527.63Ref: TM-T15675
2mg38,00€5mg56,00€10mg70,00€25mg126,00€50mg243,00€100mg416,00€200mg562,00€1mL*10mM (DMSO)65,00€Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Fórmula:C28H30N6OSPureza:100% - 99.55%Forma y color:SolidPeso molecular:498.64Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFórmula:C29H27F3N6OPureza:98% - 99.60%Forma y color:SolidPeso molecular:532.56
