IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Productos de "IGF-1R"
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GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Fórmula:C44H47F2N9O5SPureza:98.07% - 99%Forma y color:SolidPeso molecular:851.96BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFórmula:C25H26ClN5O3Pureza:99.02%Forma y color:SolidPeso molecular:479.96AZ7550 trimesylate salt
CAS:AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 inhibits IGF1R activity and can be used in the study of lung cancer.Fórmula:C30H43N7O11S3Pureza:99.24%Forma y color:SolidPeso molecular:773.9IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisForma y color:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Fórmula:C16H14BrNO5SPureza:97.55%Forma y color:SolidPeso molecular:412.26I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Fórmula:C17H12INO5Pureza:96.66%Forma y color:SolidPeso molecular:437.19Ref: TM-T11593
1mg56,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)131,00€cis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Fórmula:C28H31N5OForma y color:SolidPeso molecular:453.59Linsitinib
CAS:OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Fórmula:C26H23N5OPureza:98.98% - ≥95%Forma y color:SolidPeso molecular:421.49NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Forma y color:SolidPeso molecular:468.94Ref: TM-T1918
1mg48,00€2mg63,00€5mg101,00€10mg163,00€25mg264,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)101,00€AGL-2263
CAS:AGL-2263 is a blocker of insulin receptor (IR)Fórmula:C17H10N2O5Forma y color:SolidPeso molecular:322.27Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Fórmula:C8H5NO2S2Pureza:99.77%Forma y color:SolidPeso molecular:211.26Ref: TM-T71812
1mg96,00€5mg227,00€10mg329,00€25mg567,00€50mg753,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)250,00€Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Fórmula:C22H22O8Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:414.41Ref: TM-T6943
5mg64,00€10mg88,00€25mg170,00€50mg316,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)69,00€KW-2450 free base
CAS:KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.Fórmula:C28H29N5O3SPureza:99.11%Forma y color:SolidPeso molecular:515.63Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C28H36ClN5O3SPureza:100% - 99.77%Forma y color:SolidPeso molecular:558.14CL-A3-7
CAS:CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.Fórmula:C24H22Br2F2N2O3Forma y color:SolidPeso molecular:584.25ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€Insulin(cattle)
CAS:Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Fórmula:C254H377N65O75S6Pureza:98%Forma y color:SolidPeso molecular:5733.49NBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Fórmula:C17H11NO7Pureza:99.83%Forma y color:SolidPeso molecular:341.27HNMPA
CAS:HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.Fórmula:C11H11O4PPureza:99.11%Forma y color:SolidPeso molecular:238.18Ref: TM-T21761
1mg50,00€2mg65,00€5mg93,00€10mg144,00€25mg301,00€50mg452,00€100mg660,00€500mg1.396,00€1mL*10mM (DMSO)106,00€NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFórmula:C28H31N5OPureza:99.22% - 99.79%Forma y color:SolidPeso molecular:453.58
