Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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BIO-2007817
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.Fórmula:C32H36N6O3Forma y color:SolidPeso molecular:552.67Vialinin A
CAS:Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Fórmula:C34H26O8Pureza:99.89%Forma y color:SolidPeso molecular:562.57ZM223
CAS:ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).Fórmula:C23H17F3N4O2S2Pureza:99.67%Forma y color:SolidPeso molecular:502.53Ref: TM-T13412
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Fórmula:C27H28ClN3O3SPureza:96.18%Forma y color:SolidPeso molecular:510.05Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFórmula:C29H31F4N5O2Pureza:98%Forma y color:SolidPeso molecular:557.58TAS4464
CAS:TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).Fórmula:C21H23FN6O6SPureza:98.27%Forma y color:SolidPeso molecular:506.51USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:100% - 96.31%Forma y color:SolidPeso molecular:368.41MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Fórmula:C29H30F3N5O2Pureza:98%Forma y color:SolidPeso molecular:537.58Pevonedistat
CAS:Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM).Fórmula:C21H25N5O4SPureza:95% - 99.92%Forma y color:SolidPeso molecular:443.52Ref: TM-T6332
1mg52,00€2mg70,00€5mg96,00€10mg144,00€25mg259,00€50mg424,00€100mg717,00€1mL*10mM (DMSO)94,00€USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Fórmula:C19H20ClF3N4OSPureza:98.83%Forma y color:SolidPeso molecular:444.9Ref: TM-T67876
1mg88,00€5mg210,00€10mg329,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)245,00€Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Fórmula:C18H13BrN2O4S2Pureza:100%Forma y color:SolidPeso molecular:465.34Ref: TM-T4253
2mg37,00€5mg55,00€10mg89,00€25mg167,00€50mg279,00€100mg408,00€200mg567,00€1mL*10mM (DMSO)57,00€DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Fórmula:C19H13BrClNO5SPureza:99.71%Forma y color:SolidPeso molecular:482.73LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Fórmula:C30H50OPureza:97.99% - 99.67%Forma y color:SolidPeso molecular:426.72NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Fórmula:C21H22ClNOPureza:99.74% - 99.87%Forma y color:SolidPeso molecular:339.86USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41Ref: TM-T9217
1mg48,00€5mg97,00€10mg156,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)105,00€TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Fórmula:C9H2Cl4O2Pureza:99.34%Forma y color:SolidPeso molecular:283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFórmula:C22H17Cl2FN2O4Pureza:99.90%Forma y color:SolidPeso molecular:463.29NSC697923
CAS:NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.Fórmula:C11H9NO5SPureza:97% - 99.69%Forma y color:SolidPeso molecular:267.26Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Fórmula:C21H19F3N6Forma y color:SolidPeso molecular:412.41DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Fórmula:C16H9N5OPureza:99.34%Forma y color:SolidPeso molecular:287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Fórmula:C26H28FN3O4SPureza:99.03%Forma y color:SolidPeso molecular:497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€Ginkgolic Acid
CAS:Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.Fórmula:C22H34O3Pureza:98.69% - 99.9%Forma y color:White PowderPeso molecular:346.5P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Forma y color:SolidPeso molecular:348.22MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:98.5%Forma y color:SoildPeso molecular:412.49Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFórmula:C24H29ClN6O2Pureza:98%Forma y color:SolidPeso molecular:468.98DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:98.46%Forma y color:SolidPeso molecular:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€500mg1.454,00€1mL*10mM (DMSO)120,00€I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5Ref: TM-T73560
1mg188,00€2mg255,00€5mg369,00€10mg597,00€25mg1.121,00€50mg1.700,00€100mg2.205,00€1mL*10mM (DMSO)425,00€Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFórmula:C31H35F5N6OPureza:98%Forma y color:SolidPeso molecular:602.64EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Fórmula:C25H28Cl2N4O3Pureza:98.09%Forma y color:SolidPeso molecular:503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:100% - 99.66%Forma y color:SolidPeso molecular:396.44Ref: TM-T3535
1mg38,00€5mg81,00€10mg116,00€25mg205,00€50mg329,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)88,00€STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Forma y color:SoildPeso molecular:426.83USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:97.98% - 98.5%Forma y color:SolidPeso molecular:484.4Ref: TM-T4338
1mg43,00€5mg92,00€10mg160,00€25mg329,00€50mg547,00€100mg905,00€500mg1.786,00€1mL*10mM (DMSO)99,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Forma y color:SolidPeso molecular:408.92FT671
CAS:FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).Fórmula:C24H23F4N7O3Pureza:98%Forma y color:SolidPeso molecular:533.48ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Fórmula:C24H18F3N3O3S2Pureza:100% - 99.92%Forma y color:SolidPeso molecular:517.54DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Fórmula:C11H14ClNO3Pureza:98.37%Forma y color:SolidPeso molecular:243.69USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:422.21Ref: TM-T7685
1mg35,00€5mg70,00€10mg97,00€25mg210,00€50mg321,00€100mg472,00€500mg1.035,00€1mL*10mM (DMSO)78,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.75%Forma y color:SolidPeso molecular:276.25Ref: TM-T12926
1mg94,00€2mg137,00€5mg224,00€10mg339,00€25mg560,00€50mg810,00€100mg1.121,00€500mg2.232,00€IU1
CAS:IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Fórmula:C18H21FN2OPureza:98% - 99.30%Forma y color:SolidPeso molecular:300.37CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:100% - 99.92%Forma y color:SolidPeso molecular:413.47Ref: TM-T6796
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg298,00€50mg469,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)97,00€LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Fórmula:C15H10N2O4SPureza:92.78%Forma y color:SolidPeso molecular:314.32Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Fórmula:C21H14F3N3O2SPureza:98.36% - 99.71%Forma y color:SolidPeso molecular:429.42Ref: TM-T13244
5mg70,00€10mg96,00€25mg168,00€50mg279,00€100mg418,00€500mg938,00€1mL*10mM (DMSO)77,00€Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Fórmula:C30H32F5N5OPureza:98%Forma y color:SolidPeso molecular:573.6GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38Ref: TM-T5461
1mg70,00€2mg92,00€5mg153,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)166,00€GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.14TAS4464 hydrochloride
CAS:TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Fórmula:C21H24ClFN6O6SPureza:98.3% - 98.61%Forma y color:SolidPeso molecular:542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C22H18Cl2N2O3SPureza:98.48%Forma y color:SolidPeso molecular:461.36NSC799462
NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.Fórmula:C30H32F2N6O3SForma y color:SolidPeso molecular:594.68COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Fórmula:C25H25NO5Pureza:99.23%Forma y color:SolidPeso molecular:419.47Ref: TM-T5199
1mg188,00€5mg411,00€10mg593,00€25mg1.064,00€50mg1.501,00€100mg2.080,00€200mg2.832,00€1mL*10mM (DMSO)454,00€CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Fórmula:C23H27N3O4Pureza:96.65% - 97.57%Forma y color:SolidPeso molecular:409.48WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Fórmula:C21H22N2O2Pureza:98.57%Forma y color:SolidPeso molecular:334.41Ref: TM-T9236
1mg52,00€5mg116,00€10mg182,00€25mg320,00€50mg449,00€100mg610,00€200mg822,00€1mL*10mM (DMSO)128,00€Cbl-b-IN-3
CAS:Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Fórmula:C30H34F3N5OPureza:98.99%Forma y color:SolidPeso molecular:537.62Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFórmula:C30H33F3N6O2Pureza:98%Forma y color:SolidPeso molecular:566.62USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Fórmula:C41H43N7O4SPureza:98%Forma y color:SolidPeso molecular:729.89USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Fórmula:C18H18F3N5O2SPureza:99.18%Forma y color:SolidPeso molecular:425.43Ref: TM-T67873
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)84,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:100%Forma y color:SolidPeso molecular:279.33UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFórmula:C19H18N2OSPureza:99.3%Forma y color:SolidPeso molecular:322.42Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Forma y color:SolidPeso molecular:578.1dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Fórmula:C14H11ClN4OSPureza:98.48% - 99.19%Forma y color:SolidPeso molecular:318.78BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFórmula:C25H28N8Pureza:98.66%Forma y color:SolidPeso molecular:440.54Ref: TM-T14569
1mg92,00€5mg188,00€10mg298,00€25mg502,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)215,00€C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Fórmula:C20H23N3O2Pureza:99.30%Forma y color:SolidPeso molecular:337.42Ref: TM-T9375
1mg49,00€5mg104,00€10mg169,00€25mg334,00€50mg472,00€100mg658,00€200mg930,00€1mL*10mM (DMSO)115,00€UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.41Ref: TM-T16102
1mg92,00€2mg119,00€5mg187,00€10mg274,00€25mg432,00€50mg590,00€100mg843,00€1mL*10mM (DMSO)236,00€Heclin
CAS:Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.Fórmula:C17H17NO3Pureza:94.99% - 99.25%Forma y color:SolidPeso molecular:283.32Ref: TM-T24136
1mg35,00€5mg70,00€10mg111,00€25mg205,00€50mg321,00€100mg512,00€200mg728,00€1mL*10mM (DMSO)77,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Fórmula:C22H23N3O3Pureza:99.35% - 99.81%Forma y color:SolidPeso molecular:377.44UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Fórmula:C145H238N34O44·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:3161.64 (free acid)Nutlin-3
CAS:Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction and activates p53. Nutlin-3 has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H30Cl2N4O4Pureza:98.13% - 99.89%Forma y color:SolidPeso molecular:581.49Ref: TM-T2158
1mg37,00€5mg74,00€10mg97,00€25mg197,00€50mg301,00€100mg454,00€200mg650,00€1mL*10mM (DMSO)87,00€USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Fórmula:C22H18N4Pureza:98.2%Forma y color:SolidPeso molecular:338.41VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Forma y color:Odour SolidCbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Fórmula:C28H29F3N6O2Pureza:98%Forma y color:SolidPeso molecular:538.56ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Fórmula:C12H22ClN3OSPureza:99.30%Forma y color:SolidPeso molecular:291.84Ref: TM-T8931L
5mg35,00€10mg52,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg495,00€1mL*10mM (DMSO)35,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.5%Forma y color:SolidPeso molecular:520.67IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85Ref: TM-T15604
1mg35,00€5mg74,00€10mg127,00€25mg263,00€50mg467,00€100mg785,00€200mg1.074,00€1mL*10mM (DMSO)81,00€Indole-3-carbinol
CAS:Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFórmula:C9H9NOPureza:100% - 97.06%Forma y color:SolidPeso molecular:147.17USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Fórmula:C18H21N5O3SPureza:98.01%Forma y color:SoildPeso molecular:387.46Ref: TM-T60146
1mg88,00€5mg187,00€10mg264,00€25mg464,00€50mg655,00€100mg944,00€1mL*10mM (DMSO)207,00€USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:98.70%Forma y color:SolidPeso molecular:425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€Direct Black 38
CAS:Direct Black 38 (Chlorazol Black E) is a black azo dye that is genotoxic and induces unplanned DNA synthesis in rat liver and bone marrow micronuclei.Fórmula:C34H25N9Na2O7S2Pureza:98%Forma y color:Grey-Black Powder Physical Description Gray-Black Microcrystals Or Black Powder (Ntp 1992)Peso molecular:781.73E3 ligase Ligand 36
CAS:E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Fórmula:C25H30N4O5SForma y color:SolidPeso molecular:498.6IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.77%Forma y color:SolidPeso molecular:381.43Wu-5
CAS:Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Fórmula:C15H13NO7SPureza:99.29%Forma y color:SoildPeso molecular:351.33M435-1279
CAS:M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.Fórmula:C18H17N3O5S2Pureza:97.16%Forma y color:SolidPeso molecular:419.47Ref: TM-T9500
1mg37,00€5mg80,00€10mg114,00€25mg212,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)95,00€BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Fórmula:C23H29N3O5SPureza:99.15% - 99.72%Forma y color:SolidPeso molecular:459.56Ref: TM-T8564
1mg88,00€5mg188,00€10mg279,00€25mg535,00€50mg772,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)254,00€OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Fórmula:C19H18N2O6S2Pureza:98.19%Forma y color:SolidPeso molecular:434.49USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Fórmula:C26H22F4N6OPureza:99.60% - 99.88%Forma y color:SolidPeso molecular:510.486XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47Ref: TM-T9122
1mg96,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)283,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Fórmula:C25H28ClN3OPureza:98.76%Forma y color:SolidPeso molecular:421.96Ref: TM-T15464
1mg38,00€5mg85,00€10mg117,00€25mg187,00€50mg266,00€100mg373,00€200mg530,00€1mL*10mM (DMSO)94,00€E3 ligase Ligand 41
CAS:E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.Fórmula:C13H12ClF3N2O4Forma y color:SolidPeso molecular:352.69PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Fórmula:C7H5N5S2Pureza:100% - 99.10%Forma y color:SolidPeso molecular:223.28
