Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Productos de "Receptor sigma"
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Blarcamesine
CAS:Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.Fórmula:C19H23NOPureza:99.87%Forma y color:SolidPeso molecular:281.39BD-1047
CAS:BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Fórmula:C13H20Cl2N2Forma y color:SolidPeso molecular:275.217Amitriptyline
CAS:Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.Fórmula:C20H23NPureza:98.24% - 99.64%Forma y color:Crystals SolidPeso molecular:277.4Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Fórmula:C23H29N3OPureza:99.84% - 99.98%Forma y color:SolidPeso molecular:363.5Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Fórmula:C19H23ClFN3OPureza:100%Forma y color:SolidPeso molecular:363.86Pre-084
CAS:Pre-084 is a high affinity, selective σ1 agonist.Fórmula:C19H28ClNO3Pureza:99.91%Forma y color:SolidPeso molecular:353.88Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Fórmula:C27H33NO4Pureza:100%Forma y color:SolidPeso molecular:435.56Ref: TM-T13510
1mg64,00€5mg149,00€10mg215,00€25mg335,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)172,00€KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Fórmula:C23H30N2O6Pureza:97.72% - 99.07%Forma y color:SolidPeso molecular:430.49Ref: TM-T62396
2mg42,00€5mg62,00€10mg87,00€25mg126,00€50mg177,00€100mg263,00€500mg647,00€1mL*10mM (DMSO)67,00€SARS-CoV-2-IN-57
CAS:SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibitingFórmula:C23H37N3OPureza:98%Forma y color:SolidPeso molecular:371.56UKH-1114
CAS:UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Fórmula:C22H24F3NOForma y color:SolidPeso molecular:375.43AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.Fórmula:C25H30N2O5Pureza:98%Forma y color:SolidPeso molecular:438.52BD1063 dhydrochloride
CAS:BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Forma y color:SolidPeso molecular:346.12Ref: TM-T7488
2mg48,00€5mg72,00€10mg90,00€25mg187,00€50mg339,00€100mg499,00€200mg702,00€500mg1.074,00€Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-inducedFórmula:C22H26N2OForma y color:SolidPeso molecular:334.45KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Fórmula:C24H32N2O8Pureza:98.54%Forma y color:SolidPeso molecular:476.52PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Fórmula:C18H22N2OPureza:98%Forma y color:SolidPeso molecular:282.38Sigma-1 receptor antagonist 1
CAS:Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Fórmula:C19H23Cl2N3OPureza:99.81%Forma y color:SolidPeso molecular:380.31S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Fórmula:C20H23N3O2Pureza:99.45%Forma y color:SolidPeso molecular:337.42BMY-14802 hydrochloride
CAS:BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects.Fórmula:C18H23ClF2N4OPureza:98.64%Forma y color:SolidPeso molecular:384.85Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Fórmula:C20H26ClN3O2Pureza:99.52%Forma y color:SolidPeso molecular:375.89Ref: TM-T12911
1mg64,00€5mg145,00€10mg235,00€25mg394,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)160,00€Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Fórmula:C15H17N3Pureza:98.42%Forma y color:White To Pinkish Solid PowderPeso molecular:239.32Glycerol phenylbutyrate
CAS:Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Fórmula:C33H38O6Pureza:99.00% - 99.74%Forma y color:SolidPeso molecular:530.65AF-710B
CAS:AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.Fórmula:C20H27N3OSPureza:98.62% - 99.89%Forma y color:SolidPeso molecular:357.51KSK67
CAS:KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with KiFórmula:C22H27N3O2Pureza:99.11%Forma y color:SoildPeso molecular:365.47PD 144418 oxalate
CAS:PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Fórmula:C20H24N2O5Pureza:99.08%Forma y color:SolidPeso molecular:372.42Siramesine
CAS:Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potentFórmula:C30H31FN2OPureza:98%Forma y color:SolidPeso molecular:454.58σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Fórmula:C22H28N2O2Forma y color:SolidPeso molecular:352.47S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFórmula:C20H26ClNOPureza:98%Forma y color:SolidPeso molecular:331.88S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Fórmula:C21H28ClNOPureza:98%Forma y color:SolidPeso molecular:345.91BMY-14802
CAS:BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Fórmula:C18H22F2N4OPureza:98.93%Forma y color:SoildPeso molecular:348.39Ref: TM-T67739
1mg40,00€5mg88,00€10mg137,00€25mg264,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Sigma-1 receptor antagonist 6
CAS:Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Fórmula:C32H34N6Forma y color:SolidPeso molecular:502.65Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptorsFórmula:C26H27N3OPureza:98%Forma y color:SolidPeso molecular:397.51Cutamesine dihydrochloride
CAS:Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Fórmula:C23H32N2O2·2HClPureza:98.83% - 99%Forma y color:SolidPeso molecular:441.43Ref: TM-T3597
2mg38,00€5mg55,00€10mg96,00€25mg178,00€50mg281,00€100mg445,00€200mg640,00€1mL*10mM (DMSO)60,00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Fórmula:C21H23NOSPureza:99.80%Forma y color:SolidPeso molecular:337.48Ref: TM-T9244
2mg38,00€5mg55,00€10mg88,00€25mg170,00€50mg269,00€100mg391,00€200mg562,00€1mL*10mM (DMSO)59,00€OPC-14523 hydrochloride
CAS:OPC-14523 hydrochloride, an oral sigma/5-HT1A agonist, shows potent antidepressant activity with strong receptor affinity.Fórmula:C23H29Cl2N3O2Pureza:99.70%Forma y color:SolidPeso molecular:450.4AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Fórmula:C22H28N2Pureza:98%Forma y color:SolidPeso molecular:320.47Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFórmula:C30H32ClFN2OPureza:100% - 99.75%Forma y color:SolidPeso molecular:491.04Ref: TM-T1885
1mg60,00€2mg88,00€5mg111,00€10mg173,00€25mg354,00€50mg528,00€100mg743,00€1mL*10mM (DMSO)120,00€Roluperidone
CAS:Roluperidone (CYR-101) is a novel cyclic amide derivative.Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Forma y color:SolidPeso molecular:366.43NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Fórmula:C23H34ClNO2Pureza:98.85%Forma y color:SolidPeso molecular:391.98Ref: TM-T20797
1mg46,00€2mg57,00€5mg92,00€10mg137,00€25mg221,00€50mg329,00€100mg490,00€200mg700,00€500mg1.035,00€4-PPBP maleate
CAS:4-PPBP maleate: potent σ1 agonist, selective NR1a/2B NMDA antagonist, neuroprotective.Fórmula:C25H31NO4Pureza:99.54%Forma y color:SolidPeso molecular:409.52Ref: TM-T22513
5mg48,00€10mg74,00€25mg135,00€50mg210,00€100mg313,00€200mg442,00€1mL*10mM (DMSO)56,00€Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Fórmula:C19H24ClNOPureza:98.62% - 99.57%Forma y color:SolidPeso molecular:317.85Ref: TM-T4111
1mg46,00€2mg59,00€5mg93,00€10mg139,00€25mg255,00€50mg457,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)97,00€4-IBP
CAS:4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .Fórmula:C19H21IN2OPureza:98.99%Forma y color:SolidPeso molecular:420.29AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.Fórmula:C23H30N2O2Forma y color:SolidPeso molecular:366.5Blonanserin
CAS:Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.Fórmula:C23H30FN3Pureza:99.85%Forma y color:SolidPeso molecular:367.5BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.Fórmula:C15H24Br2Cl2N2Pureza:97.81%Forma y color:SolidPeso molecular:463.08Ref: TM-T21788
1mg65,00€5mg133,00€10mg202,00€25mg341,00€50mg507,00€100mg722,00€1mL*10mM (DMSO)157,00€BD-1047 dihydrobromide
CAS:BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacyFórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Forma y color:SolidPeso molecular:437.04Ref: TM-T1740
1mg37,00€2mg48,00€5mg73,00€10mg95,00€25mg168,00€50mg290,00€100mg490,00€1mL*10mM (DMSO)74,00€UMB24
CAS:UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.37EST64454 hydrochloride
CAS:EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.Fórmula:C18H23ClF2N4O2Pureza:99.15%Forma y color:SolidPeso molecular:400.85Ref: TM-T8834
2mg44,00€5mg65,00€10mg97,00€25mg197,00€50mg320,00€100mg509,00€200mg698,00€1mL*10mM (DMSO)81,00€S1R agonist 2
CAS:S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.Fórmula:C21H27NOPureza:99.04%Forma y color:SolidPeso molecular:309.45PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Fórmula:C19H28ClNO3Pureza:99.54%Forma y color:SolidPeso molecular:353.88Ref: TM-T3198L
5mg44,00€10mg65,00€25mg120,00€50mg207,00€100mg369,00€200mg565,00€1mL*10mM (DMSO)72,00€WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Fórmula:C21H29N5O3Pureza:98%Forma y color:SolidPeso molecular:399.49
