PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Productos de "PKA"
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8-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Forma y color:Off-White PowderPeso molecular:430.08KT5720
CAS:KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Fórmula:C32H31N3O5Pureza:98%Forma y color:SolidPeso molecular:537.61H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Fórmula:C20H20BrN3O2S·2HClPureza:100% - 99.40%Forma y color:SolidPeso molecular:519.28Ref: TM-T6250
5mg39,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€1mL*10mM (DMSO)52,00€Protein kinase G inhibitor-1
CAS:Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.Fórmula:C14H18N2O2SPureza:98.11%Forma y color:SoildPeso molecular:278.37Ref: TM-T67755
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€200mg1.444,00€1mL*10mM (DMSO)235,00€H-89
CAS:H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.Fórmula:C20H20BrN3O2SPureza:98.06%Forma y color:Off-White PowderPeso molecular:446.36Ref: TM-T11524
5mg40,00€10mg59,00€25mg114,00€50mg170,00€100mg254,00€500mg627,00€1mL*10mM (DMSO)44,00€Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:100% - ≥95%Forma y color:White SolidPeso molecular:327.83Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM byPureza:98%Forma y color:Odour SolidAT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Forma y color:SolidPeso molecular:499.5Ref: TM-T3498
1mg96,00€2mg140,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€500mg2.442,00€1mL*10mM (DMSO)259,00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.34Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Fórmula:C16H27N6O5PSPureza:98%Forma y color:SolidPeso molecular:446.46Bucladesine sodium
CAS:Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Fórmula:C18H23N5NaO8PPureza:96.56% - 99.76%Forma y color:White PowderPeso molecular:491.37AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Fórmula:C18H16N4SPureza:100%Forma y color:SoildPeso molecular:320.41A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Ref: TM-T14069
1mg35,00€5mg66,00€10mg96,00€25mg170,00€50mg274,00€100mg439,00€500mg938,00€1mL*10mM (DMSO)90,00€Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Fórmula:C31H20O10Pureza:97.74% - 99.73%Forma y color:SolidPeso molecular:552.48Ref: TM-T4S2128
1mg47,00€2mg70,00€5mg144,00€10mg250,00€25mg424,00€50mg613,00€100mg843,00€1mL*10mM (DMSO)187,00€AT7867
CAS:AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Fórmula:C20H20ClN3Pureza:99.63%Forma y color:SolidPeso molecular:337.85Ref: TM-T6304
2mg44,00€5mg65,00€10mg86,00€25mg135,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)65,00€Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Fórmula:C13H11N3OSPureza:97.57% - 97.67%Forma y color:SolidPeso molecular:257.31Ref: TM-T4661
2mg39,00€5mg56,00€10mg87,00€25mg156,00€50mg227,00€100mg344,00€500mg812,00€1mL*10mM (DMSO)62,00€Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.98%Forma y color:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg62,00€2mg87,00€5mg97,00€10mg145,00€25mg246,00€50mg401,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)109,00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Forma y color:Off-White PowderPeso molecular:298.29
