Receptor de OX
Los receptores de orexina (OX1 y OX2) son GPCR que se unen a las orexinas, neuropéptidos involucrados en la regulación de la vigilia, el apetito y la homeostasis energética. La desregulación de la señalización de la orexina está vinculada a trastornos del sueño como la narcolepsia, así como a condiciones metabólicas como la obesidad. Los moduladores de los receptores de orexina están siendo investigados por su potencial terapéutico en el tratamiento de trastornos del sueño, ansiedad y adicción. En CymitQuimica, ofrecemos una gama de moduladores de receptores de orexina de alta calidad para apoyar su investigación en biología del sueño, metabolismo y neurofarmacología.
Productos de "Receptor de OX"
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Filorexant
CAS:Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).Fórmula:C24H25FN4O2Pureza:98.88%Forma y color:SolidPeso molecular:420.48IPSU
CAS:IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.Fórmula:C23H27N5O2Pureza:97.05%Forma y color:SolidPeso molecular:405.49Ref: TM-T5503
2mg51,00€5mg86,00€10mg97,00€25mg200,00€50mg299,00€100mg432,00€200mg662,00€1mL*10mM (DMSO)92,00€SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Fórmula:C19H18F2N4OPureza:98.14%Forma y color:SolidPeso molecular:356.37MK-1064
CAS:MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:461.9SB-674042
CAS:SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is used in the treatment of depression.Fórmula:C24H21FN4O2SPureza:99.9%Forma y color:SolidPeso molecular:448.51EMPA
CAS:EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nMFórmula:C23H26N4O4SPureza:99.11%Forma y color:SolidPeso molecular:454.54Ref: TM-T11186
1mg51,00€5mg105,00€10mg157,00€25mg278,00€50mg416,00€100mg625,00€200mg873,00€1mL*10mM (DMSO)116,00€DORA-22
CAS:DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryFórmula:C23H22F2N4O2Pureza:97.67%Forma y color:SolidPeso molecular:424.44Ref: TM-T5500
1mg131,00€2mg188,00€5mg284,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)331,00€RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Fórmula:C37H37N5O5SPureza:99.17%Forma y color:SolidPeso molecular:663.79Ref: TM-T87345
1mg221,00€5mg545,00€10mg879,00€25mg1.696,00€50mg2.725,00€100mg3.686,00€1mL*10mM (DMSO)795,00€Seltorexant
CAS:Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.Fórmula:C21H22FN7OPureza:100% - 99.86%Forma y color:SolidPeso molecular:407.44Ref: TM-T12877L
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg153,00€50mg274,00€100mg378,00€500mg868,00€1mL*10mM (DMSO)87,00€Suntinorexton
CAS:Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Fórmula:C23H28F2N2O4SPureza:100%Forma y color:SolidPeso molecular:466.54Ref: TM-T39807
1mg204,00€5mg503,00€10mg727,00€25mg1.074,00€50mg1.448,00€100mg1.892,00€200mg2.539,00€1mL*10mM (DMSO)526,00€Almorexant
CAS:Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.Fórmula:C29H31F3N2O3Pureza:97.75% - 98.02%Forma y color:SolidPeso molecular:512.56TCS-OX2-29
CAS:TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.Fórmula:C23H31N3O3Pureza:99.81%Forma y color:SolidPeso molecular:397.51Ref: TM-T4965
1mg35,00€5mg70,00€10mg96,00€25mg156,00€50mg215,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)77,00€MK-3697
CAS:MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).Fórmula:C23H21N5O3SPureza:97.69% - 98.15%Forma y color:SolidPeso molecular:447.51Ref: TM-T1913
1mg52,00€2mg69,00€5mg96,00€10mg119,00€25mg210,00€50mg350,00€100mg505,00€1mL*10mM (DMSO)105,00€TCS 1102
CAS:TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Forma y color:SolidPeso molecular:470.59YNT-185
CAS:YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,Fórmula:C33H37N5O5SPureza:98.6%Forma y color:SolidPeso molecular:615.74PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Fórmula:C19H19ClFN5O3Pureza:99.67% - 99.88%Forma y color:SolidPeso molecular:419.84ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Fórmula:C20H24N2O4SPureza:99.45%Forma y color:SolidPeso molecular:388.48Ref: TM-T26559
1mg44,00€5mg93,00€10mg137,00€25mg279,00€50mg445,00€100mg707,00€500mg1.415,00€1mL*10mM (DMSO)93,00€Orexin 2 Receptor Agonist
CAS:Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.Fórmula:C32H34N4O5SPureza:98.26% - 99.43%Forma y color:SolidPeso molecular:586.7Ref: TM-T3177
2mg42,00€5mg64,00€10mg80,00€25mg137,00€50mg233,00€100mg340,00€200mg472,00€1mL*10mM (DMSO)81,00€SB-649868
CAS:SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).Fórmula:C26H24FN3O3SPureza:99.53%Forma y color:SolidPeso molecular:477.55Ref: TM-T5498
1mg37,00€5mg111,00€10mg187,00€25mg399,00€50mg645,00€100mg1.035,00€200mg1.388,00€1mL*10mM (DMSO)136,00€L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Fórmula:C26H43ClN4O5S2Pureza:99.59%Forma y color:SolidPeso molecular:591.23Ref: TM-T11794
2mg111,00€5mg156,00€10mg243,00€25mg462,00€50mg723,00€100mg1.017,00€1mL*10mM (DMSO)212,00€
