GRK
Las quinasas de receptores acoplados a proteínas G (GRK) son una familia de enzimas que fosforilan GPCR activados, lo que lleva a la desensibilización de los receptores y a la regulación de la señalización de los receptores. Las GRK desempeñan un papel crucial en el control de la intensidad y la duración de la señalización de los GPCR, lo que las hace importantes en la regulación de varios procesos fisiológicos, incluida la función cardiovascular, la respuesta inmunitaria y la neurotransmisión. Los inhibidores y activadores de GRK se estudian por su potencial en aplicaciones terapéuticas en insuficiencia cardíaca, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una gama de moduladores de GRK de alta calidad para apoyar su investigación en transducción de señales, regulación de receptores y desarrollo terapéutico.
Productos de "GRK"
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Hay 10 productos en esta categoría.
GRK5-IN-2
CAS:GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.Fórmula:C20H20N4O4Pureza:99.61%Forma y color:SolidPeso molecular:380.4Ref: TM-T9609
2mg35,00€5mg50,00€10mg80,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)55,00€GRK2-IN-1 hydrochloride (2055990-90-2 free base)
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H26ClFN4O4Pureza:98%Forma y color:SolidPeso molecular:488.94CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:452.48CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Forma y color:SolidPeso molecular:499.5Ref: TM-T3498
1mg96,00€2mg140,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€500mg2.442,00€1mL*10mM (DMSO)259,00€GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Forma y color:SolidPeso molecular:438.91Ref: TM-T62518
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.216,00€1mL*10mM (DMSO)133,00€GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C20H16Cl2N4O2Pureza:98.99%Forma y color:SolidPeso molecular:415.27Ref: TM-T27471
1mg319,00€5mg772,00€10mg1.074,00€25mg1.596,00€50mg2.147,00€100mg2.822,00€1mL*10mM (DMSO)945,00€GRK6-IN-2
CAS:GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.Fórmula:C21H21FN6Pureza:98.94%Forma y color:SolidPeso molecular:376.43Takeda103A
CAS:Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.Fórmula:C24H23F2N7OPureza:97.17%Forma y color:SolidPeso molecular:463.48Ref: TM-T24850
1mg85,00€2mg105,00€5mg164,00€10mg258,00€25mg424,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)187,00€GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C24H20N4O2Pureza:98.13% - 99.78%Forma y color:SolidPeso molecular:396.44Ref: TM-T27467
1mg140,00€5mg331,00€10mg439,00€25mg667,00€50mg894,00€100mg1.198,00€200mg1.596,00€1mL*10mM (DMSO)340,00€1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.Fórmula:C13H13NO5Pureza:99.55%Forma y color:SolidPeso molecular:263.25
![1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8913.webp&w=3840&q=75)