Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Productos de "Hedgehog / Smoothened"
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GANT 61
CAS:GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.Fórmula:C27H35N5Pureza:100% - ≥95%Forma y color:SolidPeso molecular:429.6Ellagic acid
CAS:Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.Fórmula:C14H6O8Pureza:97.11% - 99.75%Forma y color:Cream Colored Needles From Pyridine 1992)Peso molecular:302.19MRT-10
CAS:MRT-10 is a Smoothened (Smo) receptor antagonist.Fórmula:C24H23N3O5SPureza:99.47%Forma y color:SolidPeso molecular:465.52Ref: TM-T23027
1mg47,00€2mg63,00€5mg96,00€10mg135,00€25mg265,00€50mg378,00€100mg530,00€200mg720,00€1mL*10mM (DMSO)87,00€Naftifine hydrochloride
CAS:Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.Fórmula:C21H22ClNPureza:98.75% - 99.84%Forma y color:SolidPeso molecular:323.86Jervine
CAS:Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Fórmula:C27H39NO3Pureza:99.20% - 99.86%Forma y color:Needles From Methanol + Water SolidPeso molecular:425.6Ref: TM-T3363
5mg70,00€10mg119,00€25mg259,00€50mg499,00€100mg715,00€500mg1.444,00€1mL*10mM (DMSO)74,00€AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Fórmula:C25H24N4O2Pureza:99.96%Forma y color:SolidPeso molecular:412.48Taladegib
CAS:Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Fórmula:C26H24F4N6OPureza:100% - 99.39%Forma y color:SolidPeso molecular:512.5Vismodegib
CAS:Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).Fórmula:C19H14Cl2N2O3SPureza:98% - 99.99%Forma y color:SolidPeso molecular:421.3GANT 58
CAS:GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Fórmula:C24H16N4SPureza:99.53%Forma y color:SolidPeso molecular:392.48Sonidegib
CAS:Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Forma y color:SolidPeso molecular:485.5GSA-10
CAS:GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Fórmula:C26H30N2O5Pureza:≥98%Forma y color:SolidPeso molecular:450.53Purmorphamine
CAS:Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.Fórmula:C31H32N6O2Pureza:97.19% - 99.48%Forma y color:Light Tan SolidPeso molecular:520.62JK184
CAS:JK184 is a potent Hedgehog (Hh) pathway inhibitor.Fórmula:C19H18N4OSPureza:99.09% - 99.89%Forma y color:SolidPeso molecular:350.44TAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Fórmula:C28H31F3N4O6Pureza:98.79%Forma y color:SolidPeso molecular:576.56MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Fórmula:C31H29N3O5SPureza:98.31%Forma y color:SolidPeso molecular:555.64Ref: TM-T9532
1mg48,00€5mg97,00€10mg145,00€25mg255,00€50mg368,00€100mg505,00€200mg692,00€1mL*10mM (DMSO)116,00€
