Receptor S1P
Los receptores de esfingosina-1-fosfato (S1P) son una familia de GPCR que se unen a la molécula de señalización lipídica esfingosina-1-fosfato. Estos receptores desempeñan roles críticos en el tráfico de células inmunitarias, el desarrollo vascular y el mantenimiento de la integridad de las barreras endoteliales. Los moduladores de los receptores S1P se están desarrollando para el tratamiento de la esclerosis múltiple, el cáncer y las enfermedades cardiovasculares debido a su capacidad para influir en las respuestas inmunitarias y la migración celular. En CymitQuimica, ofrecemos una variedad de moduladores de receptores S1P de alta calidad para apoyar su investigación en inmunología, oncología y biología vascular.
Productos de "Receptor S1P"
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Amgen-23
CAS:Amgen-23 is a selective and highly potent sphingosine kinase 1 (SPHK1) inhibitor that inhibits SPHK2 and can be used in anticancer research.Fórmula:C23H25Cl2N3O2SPureza:97.31%Forma y color:SolidPeso molecular:478.44Opaganib
CAS:Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).Fórmula:C23H25ClN2OPureza:98.86% - 99.85%Forma y color:SolidPeso molecular:380.91Ref: TM-T6750
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg240,00€50mg415,00€100mg615,00€1mL*10mM (DMSO)87,00€Ponesimod
CAS:Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.Fórmula:C23H25ClN2O4SPureza:98.22% - 99.42%Forma y color:SolidPeso molecular:460.97Ref: TM-T3258
1mg46,00€2mg59,00€5mg93,00€10mg131,00€25mg234,00€50mg404,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)97,00€CYM-5520
CAS:CYM-5520 is a noncompetitive allosteric agonist of S1P2Fórmula:C21H19N3O2Pureza:99.47%Forma y color:SolidPeso molecular:345.39Ref: TM-T22703
1mg48,00€2mg64,00€5mg94,00€10mg142,00€25mg250,00€50mg374,00€100mg557,00€1mL*10mM (DMSO)103,00€PF429242 dihydrochloride
CAS:PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).Fórmula:C25H37Cl2N3O2Pureza:98.67%Forma y color:SolidPeso molecular:482.49MP-A08
CAS:MP-A08 selectively inhibits SPHK1; targets SphK1 & SphK2 with Ki of 6.9 μM & 27 μM, respectively.Fórmula:C27H25N3O4S2Pureza:98.04%Forma y color:SolidPeso molecular:519.64CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Fórmula:C23H27N3O4Pureza:96.65% - 97.57%Forma y color:SolidPeso molecular:409.48SLM6031434 HCl
CAS:SLM6031434 HCl (SLM-6031434 HCl) is a SphK2 inhibitor that reduces LPS-induced TNF伪 and IL-1尾 production.Fórmula:C22H31ClF3N5O2Pureza:98%Forma y color:SolidPeso molecular:489.96Etrasimod
CAS:Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).Fórmula:C26H26F3NO3Pureza:99.17% - 99.77%Forma y color:SolidPeso molecular:457.48Ref: TM-TQ0227
1mg52,00€5mg111,00€10mg180,00€25mg243,00€50mg305,00€100mg424,00€1mL*10mM (DMSO)113,00€K6PC-5
CAS:K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.Fórmula:C19H37NO4Pureza:98.55%Forma y color:SolidPeso molecular:343.5SK1-I hydrochloride
CAS:SK1-I hydrochloride is a selective and competitive SphK1 inhibitor and sphingosine analog ,anti-leukemic to inhibit tumor cell growth and promote apoptosis.Fórmula:C17H28ClNO2Pureza:99.80%Forma y color:SolidPeso molecular:313.86TASP 0277308
CAS:NH2-UAMC1110 TFA is an aminobutoxy derivative of UAMC1110 used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activating protein (fap) inhibitor.Fórmula:C23H28Cl2N6O3SForma y color:SolidPeso molecular:539.48LX-2931
CAS:LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.Fórmula:C9H15N3O5Pureza:100% - 99.83%Forma y color:SolidPeso molecular:245.23SEW2871
CAS:SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.Fórmula:C20H10F6N2OSPureza:99.62%Forma y color:White SolidPeso molecular:440.36CYM50374
CAS:CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.Fórmula:C19H19NO3SPureza:98.4% - 98.49%Forma y color:SolidPeso molecular:341.42Ref: TM-T27106
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€ML-031
CAS:ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.Fórmula:C19H20N2O3Pureza:99.21%Forma y color:SolidPeso molecular:324.374-Deoxypyridoxine hydrochloride
CAS:4-Deoxypyridoxine HCl halts S1P breakdown by blocking SPL, reducing apoptosis in insulinoma cells like S1P.Fórmula:C8H12ClNO2Pureza:99.86%Forma y color:White To Off White Crystalline PowderPeso molecular:189.64Amiselimod hydrochloride
CAS:Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.Fórmula:C19H31ClF3NO3Pureza:99.55%Forma y color:SolidPeso molecular:413.9Ref: TM-T10305
1mg38,00€2mg49,00€5mg80,00€10mg120,00€25mg215,00€50mg354,00€100mg512,00€200mg738,00€1mL*10mM (DMSO)88,00€Ozanimod hydrochloride
CAS:Ozanimod (RPC-1063) HCl is a selective S1P1/S1P5 modulator with high affinity, used in relapsing MS research.Fórmula:C23H25ClN4O3Pureza:99.81%Forma y color:SolidPeso molecular:440.92Ref: TM-T62552
1mg66,00€5mg139,00€10mg202,00€25mg416,00€50mg652,00€100mg938,00€500mg1.872,00€1mL*10mM (DMSO)154,00€CYM50308
CAS:CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM).Fórmula:C20H21F2N3O2SPureza:99.43% - 99.63%Forma y color:SolidPeso molecular:405.46Ref: TM-T15032
1mg62,00€5mg140,00€10mg202,00€25mg324,00€50mg455,00€100mg597,00€200mg842,00€500mg1.225,00€
