Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
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Productos de "Señalización PI3K / Akt / mTOR"
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EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Fórmula:C25H18N4O3Pureza:98%Forma y color:SolidPeso molecular:422.44MTK458
CAS:MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.Fórmula:C17H15F3N4Pureza:98.36%Forma y color:SolidPeso molecular:332.32Caxmotabart
Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Forma y color:Odour LiquidIHMT-PI3Kδ-372
CAS:IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.Fórmula:C26H23F2N7O2Pureza:99.54%Forma y color:SolidPeso molecular:503.5AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Forma y color:Yellow SolidPeso molecular:294.3PI3Kδ-IN-1
CAS:PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).Fórmula:C22H20F3N7O2Pureza:99.3%Forma y color:SolidPeso molecular:471.44BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:100% - 98.40%Forma y color:SolidPeso molecular:534.53Ref: TM-T6072L
1mg52,00€5mg114,00€10mg187,00€25mg411,00€50mg607,00€100mg847,00€1mL*10mM (DMSO)156,00€PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Fórmula:C32H26N8O2SPureza:98%Forma y color:SolidPeso molecular:586.67LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Fórmula:C20H22N4O2Pureza:99.48%Forma y color:SolidPeso molecular:350.41Ref: TM-T11826
1mg49,00€5mg108,00€10mg164,00€25mg284,00€50mg424,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)116,00€740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Fórmula:C143H226N43O41PS3Pureza:99.92%Forma y color:SoildPeso molecular:3330.79SKLB 1028
CAS:SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Fórmula:C24H29N9Pureza:99.71% - 99.85%Forma y color:SolidPeso molecular:443.55Ref: TM-T34656
1mg56,00€5mg119,00€10mg187,00€25mg378,00€50mg560,00€100mg800,00€500mg1.644,00€1mL*10mM (DMSO)143,00€(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Fórmula:C27H27N5O3Pureza:98%Forma y color:SolidPeso molecular:469.54Methyl 2,5-dihydroxycinnamate
CAS:Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Fórmula:C10H10O4Pureza:98.98%Forma y color:CrystallinePeso molecular:194.18PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Fórmula:C20H25F3N8O4Pureza:98.01%Forma y color:SolidPeso molecular:498.46Matuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Pureza:95%Forma y color:LiquidPeso molecular:145.9 kDabpV(phen)
CAS:bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).Fórmula:C12H8KN2O5VPureza:98%Forma y color:SolidPeso molecular:350.24HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Fórmula:C29H34ClN7OPureza:100% - 99.75%Forma y color:SolidPeso molecular:532.08EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Forma y color:Lyophilized PowderPeso molecular:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFórmula:C21H23N5O2SPureza:99.53%Forma y color:SoildPeso molecular:409.5PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Fórmula:C24H26N6O3Pureza:98.04% - ≥98%Forma y color:SolidPeso molecular:446.5
