PDK
Los inhibidores de la piruvato deshidrogenasa quinasa (PDK) se dirigen a la enzima PDK, que regula la actividad del complejo de la piruvato deshidrogenasa (PDC) y juega un papel en el control metabólico y la apoptosis. Al inhibir PDK, estos compuestos desvían el metabolismo celular de la glucólisis hacia la fosforilación oxidativa, lo que puede inducir apoptosis en células cancerosas que dependen de la glucólisis aeróbica (efecto Warburg) para sobrevivir. Los inhibidores de PDK son valiosos en la investigación del metabolismo del cáncer y el desarrollo terapéutico. En CymitQuimica, ofrecemos inhibidores de PDK de alta calidad para apoyar su investigación en metabolismo del cáncer, apoptosis y bioenergética celular.
Productos de "PDK"
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Hay 11 productos en esta categoría.
RS1-PDK1 inhibitor
CAS:RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.Fórmula:C15H9ClN2O2S3Pureza:98%Forma y color:SolidPeso molecular:380.89PS47
CAS:PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.Fórmula:C17H15ClO2Pureza:99.09%Forma y color:SolidPeso molecular:286.75Ref: TM-T24677
5mg46,00€10mg65,00€25mg123,00€50mg187,00€100mg309,00€200mg435,00€1mL*10mM (DMSO)65,00€Osu03012
CAS:Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.Fórmula:C26H19F3N4OPureza:97.95% - 99.22%Forma y color:SolidPeso molecular:460.45Ref: TM-T2466
2mg37,00€5mg51,00€10mg87,00€25mg143,00€50mg264,00€100mg349,00€200mg454,00€500mg742,00€1mL*10mM (DMSO)51,00€PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Fórmula:C15H9ClN2O2S3Pureza:98%Forma y color:SolidPeso molecular:380.89M77976
CAS:M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.Fórmula:C17H16N2O3Pureza:99.80%Forma y color:SolidPeso molecular:296.32PS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Fórmula:C14H13NO6SPureza:99.01%Forma y color:SolidPeso molecular:323.32MP7
CAS:MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Fórmula:C28H22F2N4O4Pureza:99.45% - 99.84%Forma y color:SolidPeso molecular:516.5PS 48
CAS:PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).Fórmula:C17H15ClO2Pureza:98.37% - ≥95%Forma y color:SolidPeso molecular:286.75GSK2334470
CAS:GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.Fórmula:C25H34N8OPureza:99.04% - 99.87%Forma y color:SolidPeso molecular:462.596-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFórmula:C9H6BrN3OPureza:98.81%Forma y color:SolidPeso molecular:252.07PS210
CAS:PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.Fórmula:C19H15F3O5Pureza:99.78%Forma y color:SolidPeso molecular:380.31Ref: TM-T16670
1mg37,00€2mg52,00€5mg74,00€10mg107,00€25mg197,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)85,00€
![6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT77685.webp&w=3840&q=75)
