ATM / ATR
Los inhibidores de ATM (Ataxia Telangiectasia Mutada) y ATR (ATM y Rad3-relacionada) se dirigen a quinasas clave involucradas en la respuesta al daño del ADN (DDR) que se activan en respuesta a rupturas de doble hebra de ADN y estrés replicativo. Estos inhibidores interrumpen la capacidad de estas quinasas para detectar y reparar el daño del ADN, lo que puede llevar a una mayor inestabilidad genómica y muerte celular, particularmente en células cancerosas que dependen de mecanismos robustos de reparación del ADN para sobrevivir. Los inhibidores de ATM/ATR son herramientas cruciales en la investigación y terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una amplia gama de inhibidores de ATM/ATR de alta calidad para apoyar su investigación en la respuesta al daño del ADN, biología del cáncer y desarrollo terapéutico.
Productos de "ATM / ATR"
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ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Fórmula:C23H27N7OPureza:98%Forma y color:SolidPeso molecular:417.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Fórmula:C26H31N5O3Pureza:99.03% - 99.13%Forma y color:SolidPeso molecular:461.56Schisandrin B
CAS:Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Fórmula:C23H28O6Pureza:100% - 99.84%Forma y color:SolidPeso molecular:400.46Ref: TM-T2925
1mg42,00€5mg88,00€10mg127,00€25mg230,00€50mg414,00€100mg600,00€500mg1.254,00€1mL*10mM (DMSO)94,00€Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C24H25N5O3SPureza:100% - 99.7%Forma y color:SolidPeso molecular:463.55Ref: TM-T2669
1mg35,00€5mg74,00€10mg92,00€25mg155,00€50mg225,00€100mg359,00€200mg525,00€500mg833,00€1mL*10mM (DMSO)77,00€ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Fórmula:C19H22N8OPureza:98%Forma y color:SolidPeso molecular:378.43Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFórmula:C20H21N7OPureza:98.72% - 99.84%Forma y color:SolidPeso molecular:375.43Ref: TM-T7318
1mg37,00€5mg79,00€10mg111,00€25mg216,00€50mg359,00€100mg562,00€500mg1.206,00€1mL*10mM (DMSO)87,00€PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Forma y color:SolidPeso molecular:389.88Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Fórmula:C21H26N6O3Pureza:98.15% - 99.6%Forma y color:SolidPeso molecular:410.47Ref: TM-T62083
1mg169,00€5mg416,00€10mg605,00€25mg944,00€50mg1.254,00€100mg1.730,00€1mL*10mM (DMSO)470,00€NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Fórmula:C11H17N5O2Pureza:98.36%Forma y color:SolidPeso molecular:251.29ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Fórmula:C20H24N6O2SPureza:98% - 99.99%Forma y color:SolidPeso molecular:412.51CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Fórmula:C17H15N7O2Pureza:99.14% - 99.85%Forma y color:SolidPeso molecular:349.35GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Forma y color:SolidPeso molecular:364.36azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Fórmula:C27H32FN5O2Pureza:97.41% - 99.38%Forma y color:SolidPeso molecular:477.57ATR kinase-IN-2
CAS:ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Fórmula:C21H24N4O3SPureza:100.00% - 98.02%Forma y color:SolidPeso molecular:412.51KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Fórmula:C21H17NO3S2Pureza:100% - 99.80%Forma y color:SolidPeso molecular:395.49CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.7%Forma y color:SolidPeso molecular:555.84Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Forma y color:SolidPeso molecular:469.54
