Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Dofequidar is a pyrimidine compound that is used as an immunosuppressant drug. It is used to treat autoimmune diseases and inflammatory bowel disease. Dofequidar has been shown to inhibit the transcription-polymerase chain reaction (PCR) of T lymphocytes in vitro, which may be due to its ability to bind hydrogen bonds in DNA. Dofequidar also binds to monoclonal antibodies, including anti-CD3 and anti-CD20, and inhibits the proliferation of mouse hippocampal cells.

Versatile small molecule scaffold

7-Fluoro-6-methoxy-1H-indazol-3-amine

Versatile small molecule scaffold

ethyl 2-oxo-2-{2-[4-(trifluoromethyl)pyrimidin-2-yl]hydrazino}acetate

Versatile small molecule scaffold

N-(tert-Butoxycarbonyl)-3-bromoaniline is a crystalline compound that was synthesised by reacting 3-bromoaniline with imidazolium chloride and pyridine. It has been shown to form a dimer via intramolecular nucleophilic substitution. The crystal structure of N-(tert-Butoxycarbonyl)-3-bromoaniline was determined using x-ray diffraction, which revealed the presence of phenylenes at the termini of the molecule. N-(tert-Butoxycarbonyl)-3-bromoaniline is an intermediate in the synthesis of various drugs including antihistamines, antibiotics and analgesics.

Versatile small molecule scaffold

5-Aminouracil-6-carboxylic acid

Versatile small molecule scaffold

5-Iodo-2-methyl-2H-pyrazolo[3,4-b]pyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-N,N-dimethylpyridin-2-amine

N-(6-Aminobenzothiazol-2-yl)acetamide is a cyclic molecule that has both optical and electron transfer properties. It is an efficient inhibitor of the enzyme, benzene, which catalyzes the oxidation of benzene to benzoquinone. This compound can be synthesized using a number of techniques, including cyclization by reaction with acetamide. The molecule is a semiconductor with potentiodynamic polarization properties in the region of visible light. This property is useful for optical absorption spectroscopy and voltammetry experiments. Inhibition efficiency can be determined spectroscopically or by kinetic experiments such as measuring the rate of electron transfer between the inhibitor and substrate. The morphology of N-(6-aminobenzothiazol-2-yl)acetamide crystals can be studied using techniques such as X-ray diffraction or scanning electron microscopy.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(R)-2-Benzylpiperidine

2-Methoxy-phenoxy)-acetyl chloride is a ligand that binds to metal ions such as chloride and phenoxyacetic. It has a multidentate shape with two oxo groups, which make it a good ligand for metal ions. 2-Methoxy-phenoxy)-acetyl chloride is used in the synthesis of chlorinated phenols.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

But-3-ene-1-sulfonamide is a synthetic macrocycle that is used to treat hepatitis C. It prevents the virus from replicating, and has been shown to be effective in the treatment of chronic hepatitis C. But-3-ene-1-sulfonamide binds to the NS5B protein in the viral ribonucleoprotein complex, which stops viral replication by inhibiting RNA synthesis. The drug also inhibits the production of new virus particles by binding to the surface of cells in a noncompetitive manner. But-3-ene-1-sulfonamide has a pharmacokinetic half life of 10 hours, and is approved for use only in patients with chronic hepatitis C who have not responded to other treatments.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Phthalimid-1-yl)butanoic acid

3-Phenyl-1H-pyrazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(4-Chlorophenyl)(piperidin-4-yl)methanone hydrochloride

2-Methyl-4-(piperazin-1-yl)quinoline

Versatile small molecule scaffold

Ethyl 7-aminoheptanoate is a prodrug that is converted to medoxomil in vivo. Medoxomil is an inhibitor of platelet aggregation and has been shown to be effective in preventing thrombosis. It also reduces the sensitivity of rats to certain drugs, although the mechanism of this effect is not known. Ethyl 7-aminoheptanoate has been shown to have low toxicity in rats, but high toxicity in mice. This drug has been found to be stable in vitro and can be used as a pharmacokinetic model for other drugs with similar properties such as benzamidine, which is also metabolized by liver enzymes such as CYP2C9 and CYP3A4.

Versatile small molecule scaffold

6-Bromo-3-methoxy-1H-indazole

Versatile small molecule scaffold

tert-Butyl N-[1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate

7-Hydroxy-1-methyl-1H-indazole

Applications D-Phenyl-d5-alanine-2,3,3-d3 (CAS# 1202064-02-5) is a useful isotopically labeled research compound.

Versatile small molecule scaffold

N-Phenylcyclobutanecarboxamide is a sulfone that is used as a chemotherapy agent. It has been shown to be effective in the treatment of peritoneal carcinomatosis and pancreatic cancer. This drug inhibits the growth of cancer cells by interfering with DNA synthesis and protein synthesis, which prevents cell division. N-Phenylcyclobutanecarboxamide also causes tumor cells to die by causing them to undergo apoptosis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethanol, 2-(phenylsulfonyl)- is a synthetic chemical compound. It is used as an electron donor in the Suzuki coupling reaction and has shown significant cytotoxicity against tumour cell lines. This product also has been used in the synthesis of naphthalene and pulchella. The mechanism for its cytotoxicity involves the desulfurization of tyrosinase, which is an enzyme that catalyzes the conversion of dihydroxyphenylalanine to melanin. This product has also been shown to be effective against glandularia with structural studies showing that it reacts with sulfonic acid groups.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Ethyl-4-methoxypyridine 1-oxide

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 2-bromobenzoate is a chemical compound that can be used as a light emitting material. It is also used as a component of organic electrochemical cells (OECs) for the conversion of solar energy to electricity and can be used in the treatment of hepatitis. The reaction product is generated from the reaction of the halide with benzoate and light, which leads to an emission spectrum in the visible region. Methyl 2-bromobenzoate has been shown to be an efficient catalyst for Friedel-Crafts reactions, and it's pharmacokinetic properties have been studied in rats. Methyl 2-bromobenzoate can also be used as a solid catalyst for the synthesis of bicyclic heterocycles.

(3E)-4-{1,4-Dioxa-8-azaspiro[4.5]decan-8-yl}-1,1,1-trifluorobut-3-en-2-one

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-4-phenylpyridine

Applications N,N-Diethylbutyramide is a compound that has been used as a pretreatment before N,N-Dimethyltryptamine (D469620) to decrease its hallucinogenic activity. References Smythies, J.R., et al.: Eur. J. Pharmacol., 17, 270-2 (1972);

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-3-nitrobenzoic acid is a diketone that is used as a synthetic building block for the synthesis of fatty acid esters. This compound is also used to normalize butyric acid levels in blood, and has been shown to inhibit the formation of coumarin derivatives from nitrosalicylic acid. 2-Methyl-3-nitrobenzoic acid is an organic molecule with a molecular weight of 128.17 g/mol, and has four functional groups: two methyl groups, one carboxyl group, and one phenyl group. The compound reacts with a solution containing nitrite ions in an acidic environment to form nitrous acid (HONO) and 2-methylene-3-nitrobenzaldehyde (2MNB). 2MNB is soluble in water and has a solubility data of 0.0012 g/100 mL at 25 degrees Celsius.

7-(Trifluoromethyl)-1H-indole-2-carboxylic acid

Ethyl 2-(benzylamino)-5-chloronicotinate

Versatile small molecule scaffold

Versatile small molecule scaffold

1,3-Diethylpyrimidine-2,4,6(1H,3H,5H)-trione

1-(2-Chlorophenyl)pyrazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 4-hydroxy-2-piperidinecarboxylate is a versatile compound with various applications. It can be used as an anesthetic, in research chemicals, and as an electrode. Additionally, it has been found to have inhibitory effects on certain enzymes and compounds such as lorcaserin hydrochloride, sulfometuron methyl, disaccharides, tenofovir, halides, promazine sulfometuron. Furthermore, it has anticoagulant properties that make it useful in the field of anticoagulation. Methyl 4-hydroxy-2-piperidinecarboxylate is derived from xylose and offers a wide range of potential uses in different industries.

Versatile small molecule scaffold

Alpha-cyclopropylbenzyl alcohol is an organic compound that belongs to the group of carbinols. The most common use of this compound is as a reactant in the Diels-Alder reaction. This reaction involves the formation of a new carbon-carbon bond with two electron-deficient olefins and a dienophile, which can be either an alkene or another diisocyanate. Alpha-cyclopropylbenzyl alcohol reacts selectively with methyl ethyl, isopropyl, and n-propyl groups, which are present in many diisocyanates. The product of this reaction is always a ring-opening adduct containing aldehydes or urethanes. These reactions often produce polyesters as well when alpha-cyclopropylbenzyl alcohol reacts with cyclohexanedimethanol.

Versatile small molecule scaffold

Trifluoroacetic acid is a reactive compound that can be used to produce amines by activation with trimethylsilyl. It is also used in the synthesis of other compounds, such as silanes and thiocyanates. Trifluoroacetic acid has been shown to be an effective treatment for autoimmune diseases, such as inflammatory bowel disease, alopecia areata, and rheumatoid arthritis. It has also been shown to inhibit the production of pro-inflammatory cytokines in human monocytes. Trifluoroacetic acid has chemical stability in organic solvents and does not react with water or alcohols.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-[Amino(hydroxyimino)methyl]-N-hydroxy-2-pyridinecarboxamide