Glycoscience

1,2-Di-O-acetyl-3-O-benzyl-4-C-(phenylmethoxy)methyl-L-Lyxofuranose 5-methanesulfonate is a high purity, custom synthesis sugar that has been modified with fluorination, glycosylation and methylation. It is also a synthetic saccharide that can be used in the modification of oligosaccharides and monosaccharides. This product is available in a variety of different quantities.

1,2,3,4,6-Penta-O-benzoyl-b-D-glucopyranose is a synthetic substrate that has been validated for use in heparin assays. It is an inhibitor of the enzyme sulfate protease and can be used to study the role of this enzyme in inflammation. 1,2,3,4,6-Penta-O-benzoyl-b-D-glucopyranose has also been shown to inhibit the activity of neutrophils (a type of white blood cell) and monocytes (a type of white blood cell). This compound has been shown to have antitumor activity as well as antiinflammatory activities.

4-Aminobenzyl b-D-thiogalactopyranoside is a chemical compound that belongs to the group of glycosylation, complex carbohydrate, Methylation, Click modification, Polysaccharide, Fluorination, saccharide, Modification and sugar. It is a synthetic product that can be modified according to customer requests. 4-Aminobenzyl b-D-thiogalactopyranoside is an oligosaccharide that has been custom synthesized for high purity. This product can be used in various applications such as pharmaceuticals and biochemistry research.

This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.

3-Cyclohexylpropyl-b-D-glucopyranoside is a synthetic glycoside that is used as an intermediate in the production of complex carbohydrates. This product is custom synthesized and available at a purity of 99%. It can be modified with methylation, glycosylation, or click chemistry. The saccharide can also be fluorinated for use in the synthesis of other products. 3-Cyclohexylpropyl-b-D-glucopyranoside has been shown to be stable during storage at room temperature for up to three months.

D-ribulose 1,5-bisphosphate sodium hydrate (DRBP) is a naturally occurring sugar that is found in plants. It is synthesized by the action of ribulose bisphosphate carboxylase on ribulose 1,5-bisphosphate, with ATP as a cofactor. DRBP has been shown to be an important intermediate in many biochemical pathways and enzymes. DRBP has been shown to inhibit HIV replication in vitro by binding to the enzyme reverse transcriptase and blocking its activity. As an inhibitor of HIV replication, DRBP is activated by a number of factors including p-nitrophenyl phosphate (pNPP), and the presence of hydrogen bond donors such as ATP or NADP+. This chemical also inhibits protease activity and increases the transport rate for D-ribulose 1,5-bisphosphate.

a-D-Glucose-1-phosphate disodium salt hydrate (aGPD) is a bacterial strain that has been shown to produce fatty acids from glucose. The production of fatty acids has been shown to be dependent on transfer reactions involving tagatose, which is an intermediate product of the process optimization of aGPD. The final product of these reactions is lactic acid, which is formed in an acidic environment. This bacterial strain has also been used as a model system for studying kidney bean phosphatase and photosynthetic activity in monoclonal antibody production.

4,6-O-Benzylidene-2,3-di-O-(4-methoxybenzyl)-a-D-galactopyranosyl fluoride is a glycosylation reagent that is used in the synthesis of complex carbohydrates. This product is a fluorinated sugar with a CAS number and a high purity. It can be custom synthesized to order.

Phosphoric acid mono-((2R,3R,4S,5R)-2,3,4,5,7-pentahydroxy-6-hydroxyimino-heptyl) ester disodium salt (compound H) is a high purity compound that can be custom synthesized to suit the customer's needs. It is a synthetically modified sugar with Click modification. This product has been fluorinated and glycosylated. Modification and methylation are also available on request.

Shortest chain oligosaccharide that can be classified as a maltodextrin. A component of liquid glucose (a commercial sweetener composed of glucose, maltose, maltotriose and maltotetrose).

Methyl 2,3-di-O-benzyl-4,6-O-benzylidene-a-D-mannopyranoside is a custom synthesis of a complex carbohydrate. It is an Oligosaccharide and Polysaccharide that has been modified by methylation and glycosylation. This carbohydrate is saccharide with a high purity and a high degree of Fluorination. Methyl 2,3-di-O-benzyl-4,6-O-benzylidene-a-D-mannopyranoside is synthesized by Click chemistry using sugar as the starting material. The synthesis involves two steps: first, the sugar moiety was protected by benzylation to yield benzyl 2,3 di O acetate; second, it was methylated to give the desired product.

Tetradecyl b-D-maltopyranoside is a crystalline polymer of high molecular weight that is made up of repeating units of tetradecyl b-D-maltose. It has a lamellar morphology and can be sectioned with techniques such as electron microscopy, X-ray diffraction, and differential scanning calorimetry. Tetradecyl b-D-maltopyranoside is a metastable form of the compound. It has been found in nature in the form of the monomer unit, tetradecyl maltosyl (tetramethyleneglycol) b-d-maltoside. In order to produce this compound as a polymer, it must first be heated to about 160°C for several hours, which causes the monomers to assemble into chains of tetrahedrons. The properties of tetradecyl b-D-maltopyranoside depend on its environment

Chitosan oligomer (Dp 3-7) hydrochloride is a carbohydrate with a molecular weight of 1640. It is used as a sugar and an adjuvant in vaccine development. Chitosan oligomer (Dp 3-7) hydrochloride is synthesized by the reaction of chitosan with phosphoryl chloride and has been shown to have antiviral, antibacterial, and anti-inflammatory effects.

Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

1,2,3,5,6-Penta-O-acetyl-D-galactofuranose is a condensation product of a 4-methylumbelliferone with the anomeric form of D-galactose. It is a white crystalline solid that can be obtained in yields up to 200 g per multigram of reactants. This compound has been shown to react with chloride ion and zinc chloride at elevated temperatures to yield the corresponding chloride or zinc salt. The crystal structure of this compound has been studied by x-ray diffraction and found to have an anomeric configuration and a space group P2(1)22(1). Carbohydrates are polyhydroxyaldehydes or polyhydroxyketones containing at least one hemiacetal or hemiketal group in their structure. The general formula for carbohydrates is (Cx(H2O)y)z where x is usually 2 or 3, y is

Applications Isotope Labelled 2-(α-D-Mannopyranosyl)-L-tryptophan is a tryptophan glycoconjugate being tested as an diagnostic tool for the accurate measure of renal function. References Yonemura, K., et al.: Kidney. Int., 65, 1395 (2004); Kehraus, S., et al.: J. Med. Chem., 47, 2243 (2004);

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1,2,3,4-Tetra-O-benzoyl-a-D-glucuronide methyl ester is a synthetic compound that belongs to the class of complex carbohydrates. It has been custom synthesized and modified using glycosylation, methylation, and click chemistry. It is composed of one monosaccharide and four oligosaccharides linked together by O-glycosidic bonds. The carbohydrate moiety contains a benzoyl group attached to the 1 position on the glucose molecule through an ether linkage. This product is available in high purity (≥ 99%) at CAS No. 201789-32-4.

Enantiomer of natural L-Rha 13C-labelled at carbons 1 and 2

Essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 and myeloid differentiation protein 2.

Ethyl 4,6-O-(4-methoxybenzylidene)-b-D-thiogalactopyranoside is a custom synthesis of a carbohydrate. It is a high purity product with a purity of at least 99.0%. It has the following properties: Custom synthesis, sugar, Click modification, Fluorination, Glycosylation, Synthetic, Methylation, Modification. This product is registered under CAS No. 100735-66-8 and has the molecular formula C51H75NO17. The molecular weight is 905.1 g/mol and the structural formula is as follows:

2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-a-D-galactopyranosyl-1-O-[4-(aminomethyl)benzoyl]-L-serine (2ADOGB) is a side chain of the amino acid L -serine. It has been shown to have antihypertensive, vasodilatory, and diuretic properties in mice. 2ADOGB is converted to an erythroimidazole derivative by aminomethylation and then binds to DNA as a tautomer. This binding inhibits transcription of genes that encode enzymes responsible for synthesizing prostaglandins, thereby reducing inflammation and pain.

Curcumin b-D-glucuronide is a glucuronide conjugate of the curcumin molecule. It has been shown to have anticancer activity in mouse tumor models and human metastatic colorectal cancer cell lines by inducing apoptosis. Curcumin b-D-glucuronide is metabolized by the liver microsomes of rats, and thus may be useful for the prevention of colon cancer. Curcumin b-D-glucuronide also has anti-inflammatory properties that are due to its inhibition of prostaglandin E2 (PGE2) levels in humans.

(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one is a nucleoside that has been synthesized and characterized by x-ray crystallographic analysis. It is an analog of the nucleoside fluorouracil which has been fluorinated at the 5 position of the oxo group. The crystal structure of (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one was determined using x ray crystallography to be a lactone with an anhydrous form. This compound is currently being investigated as a potential drug candidate for cancer treatment.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Alpha-cyclodextrin (α-CD) derivative with a hydrophilic exterior and lipophilic cavity (smaller than β-CDs and γ-CDs) to allocate certain guest molecules. This structural characteristic enables applications in molecular encapsulation, solubility enhancement, and stabilization across multiple industries. In pharmaceuticals, it serves as a drug delivery vehicle, enhancing the bioavailability and stability of active ingredients. The food industry utilizes it as a stabilizer for flavors, colors, and nutrients, as well as a functional ingredient for its effects on lipid metabolism. In cosmetics, it acts as a complex agent for fragrances and active components. Its applications extend to analytical chemistry for chiral separation and to materials science for developing smart materials and nanosystems.

Benzyl 2-acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a synthetic saccharide. The chemical structure of this material has been modified by fluorination, methylation, and click modification. This product is soluble in water and can be used as a starting material for the synthesis of polysaccharides.

(4R)-Benzyl-4-deoxy-4-C-nitrophenyl-b-D-arabinopyranoside is a synthetic glycoside that has been modified by fluorination and saccharide. It is a custom synthesis, which means it can be synthesized to order with high purity. This compound is used in the modification of glycoconjugates and polysaccharides, as well as the synthesis of oligosaccharides. It is also used in click chemistry, which involves the use of copper and azide ions.

N-omega-(2-Acetamido-2-deoxy-b-D-glucopyranosyl)-N-aBocL-asparagine is a custom synthesis of an oligosaccharide that has been modified by fluorination, methylation and Click chemistry. This product is also a monosaccharide, saccharide or carbohydrate that is used in the modification of proteins. It has CAS No. 137255-40-4 and can be used as a synthetic building block for the synthesis of various saccharides with glycosylation reactions.

Polyimides are polymers that are used in a variety of industrial and consumer products. Ethyl 2,3,4,6-tetra-O-acetyl-b-D-thioglucopyranoside is a type of polyimide that has been shown to be photosynthetic. Polyimides are synthesized by condensing acetylene with formaldehyde in the presence of an acid catalyst. This compound has been investigated for use as an active component in photonic and optoelectronic devices such as solar cells and light emitting diodes (LEDs). The material is also being explored for use in the fabrication of microelectronic devices such as field effect transistors (FETs) and optical switches. It can be used to investigate organisms’ photosynthetic activity qualitatively or quantitatively by observing color changes or measuring oxygen production.

2,4,7,8,9-Pentaacetyl-N-[(2-propen-1-yloxy)carbonyl]-b-neuraminic acid methyl ester is a Glycosylation reagent that is used in the synthesis of oligosaccharide and polysaccharide. The product can be modified to produce Click modifications and complex carbohydrates. It has been shown to have high purity and can be custom synthesized.

3,4,6-Tri-O-acetyl-2-azido-2-deoxy-D-galactose is a sialylated glycoside with a carbohydrate and an amino sugar. It is a stereoselective analog of sialoside, which is the product of the reaction between neuraminic acid with D-galactose. The enzyme that catalyzes this reaction is called sialoglycolysis. 3,4,6-Tri-O-acetyl-2-azido-2-deoxy -D -galactose has been shown to be an efficient catalyst for the synthesis of glycosylamines from disaccharides and trifluoromethanesulfonate in solid phase.

1,2:3,4-Di-O-isopropylidene-6-deoxy-6-tosyl-a-D-galactopyranose is a synthetic compound that has been modified by fluorination and glycosylation. It is used as an intermediate in the synthesis of oligosaccharides and polysaccharides. The compound has been custom synthesized to a high purity level with minimal impurities. The product is available in monosaccharide form or as a complex carbohydrate.

3-Amino-2,3,6-trideoxy-L-arabino-hexose hydrochloride is a fluorinated sugar. It is synthesized by the fluorination of arabinose. This compound has a high degree of substitution and can be used for glycosylation reactions or modification reactions. 3-Amino-2,3,6-trideoxy-L-arabino-hexose hydrochloride has CAS number 56501-70-3 and is soluble in water.

N-Acetylneuraminic acid (NA2) is a glycan that is found in the human body, and is important for brain function. NA2 Glycan, 2-AB labelled, is a high purity custom synthesis sugar with Click modification and fluorination. The glycans are made of monosaccharides or saccharides linked together by glycosidic bonds. Carbohydrates are classified according to their number of sugar units: simple carbohydrates contain one or two sugar units; complex carbohydrates have three or more. This product is an oligosaccharide that contains nine sugar units: three monosaccharides and six saccharides. It can be used as a substrate for methylation, glycosylation, and modification reactions.

2-Deoxy-2-fluoro-L-[UL-13C]fucose is a modified sugar molecule used in various scientific applications, particularly in glycobiology and drug development.  It's used to study fucose-containing glycans, enzyme interactions, metabolic pathways, and glycoengineering. For instance, it can be incorporated into proteins to investigate the effects of fucose modifications on their function or used to develop drugs targeting fucose-metabolizing enzymes

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Nepetin-7-glucoside is a compound found in plants that has been shown to have anti-inflammatory and antiviral properties. Nepetin-7-glucoside inhibits the activity of enzymes such as phospholipase A2, cyclooxygenase, and lipoxygenase. It also reduces the production of inflammatory mediators such as prostaglandins and leukotrienes. Nepetin-7-glucoside may be helpful in the treatment of autoimmune diseases and other inflammatory disorders. This compound also has antiviral effects by inhibiting the replication of herpes simplex virus type 1 (HSV1) in a cell culture system. Nepetin-7-glucoside also has been shown to inhibit the expression of genes related to inflammation and other inflammatory diseases, such as rheumatoid arthritis, colitis ulcerosa, psoriasis, and Crohn's disease.

Methyl D-arabinofuranoside is an antimycobacterial agent that inhibits the synthesis of mycolic acids, which are important components of the cell wall of Mycobacterium tuberculosis. Methyl D-arabinofuranoside has been shown to be active against drug-resistant strains and has been well tolerated by animals. This compound can be synthesized from 2,4-dichlorophenylacetic acid and arabinose in two steps. The first step involves a three-component condensation reaction with sodium hydroxide, hydrochloric acid, and 2,4-dichlorophenylacetic acid. The second step is a nucleophilic attack on the pyran ring of methyl D-arabinofuranoside with hypophosphorous acid. Methyl D-arabinofuranoside can also be prepared by reacting sodium nitrosobenzene with sodium benzene sulfinate in alcoholic solution