Antifúngicos

Anti-fungal; lanosterol 14α-demethylase inhibitor

Neticonazole has anti-infective and anti-cancer effects, inhibits exosome secretion, and can be used to study Candida albicans infection of the skin.

2-Methyl-4-isothiazolin-3-one or MIT is a powerful antimicrobial and antifungal agent which is widely used in personal care products. It is also used in industrial applications as a preservative and antifouling agent.

Caulilexin C inhibits hACAT1 and hACAT2 at 100 µg/ml.

Bitertanol (KWG 0599) is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis.

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections.

Amphotericin A is a polyene macrolide antibiotic, which is derived primarily from the soil bacterium *Streptomyces nodosus*. This compound functions by binding to ergosterol, an essential component of fungal cell membranes. This binding creates pores in the membrane, increasing its permeability and ultimately leading to cell death. Unlike its more widely used counterpart Amphotericin B, Amphotericin A is less frequently utilized but is critical in the study and understanding of antifungal activity. While Amphotericin A itself is not commonly used for clinical applications due to its lower efficacy compared to Amphotericin B, it plays a significant role in research settings. Its primary utility is in the investigation of the structure-activity relationship of polyene antibiotics, contributing to the development and enhancement of antifungal therapies. Scientists utilize Amphotericin A to understand the mechanisms behind antifungal drug resistance and to design synthetic derivatives with improved therapeutic profiles and reduced toxicity.

Isavuconazonium sulfate is a prodrug converted to antifungal isavuconazole, inhibiting fungal enzyme CYP51 to disrupt cell membrane synthesis.

Griseofulvin is an antifungal drug used to treat several types of dermatophytosis (ringworm). This includes fungal infections of the nails, scalp and the skin when antifungal creams have not worked. It is suggested that it prevents nuclear acid production and fungal cell mitosis. Additionally, through binding to alpha and beta tubulin, it interferes with the function of the spindle and cytoplasmic microtubules. Griseofulvin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

LW3 is an effective broad-spectrum antifungal compound.

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- can be used as a broad-spectrum antimicrobial agent with inhibitory activity against Aspergillus niger

Sertaconazole is a broad-spectrum antifungal.

Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.

Applications Blasticidin S Hydrochloride is a fungicide and antibiotic produced by Streptomyces griseochromogenes. Potential inhibitor of protein synthesis in bacteria and eukaryotes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Svidritskiy, E. et al.: Proc. Natl. Acad. Sci. U.S.A., 110, 12283 (2013); Izumi, M. et al.: Exp. Cell. Res., 197, 229 (1991);

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia. Itraconazole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Lucimycin is an antibiotic, which is derived from the fermentation of specific Streptomyces bacterial strains. This compound exerts its antibacterial effects by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis and effectively halting bacterial growth. Lucimycin is particularly effective against Gram-positive bacteria and some Gram-negative species, making it a valuable tool in both clinical and research settings. The primary applications of Lucimycin are in the treatment of various bacterial infections where conventional antibiotics may fail or serve as second-line treatments. In research laboratories, it is often used to study bacterial resistance mechanisms and the efficacy of novel antibacterial combinations. Its unique mode of action provides essential insights into ribosomal function and protein synthesis pathways, contributing to the broader understanding of microbial biochemistry and cellular biology. Due to its potent inhibitory effects and specific action, Lucimycin remains a critical component in the arsenal against multidrug-resistant bacterial strains.

Fluxapyroxad is a broad-spectrum fungicide that inhibits the succinate dehydrogenase (SQR) enzyme.

Lawsone, a red-orange dye, found in henna leaves and water hyacinth flowers, is also 2-hydroxy-1,4-naphthoquinone.

Applications Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors. References Turlington, M., et al.: Bioorg, Med. Chem. Lett., 23, 6172 (2013); Chen, Y., et al.: Faming Zhuanli Shenqing. CN 103664902 A 20140326. Mar 26, 2014

beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.

Stability Hygroscopic Applications L-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics. References Nakamura, T., et al.: Biol. Pharm. Bull., 31, 1580 (2008), Yang, J., et al.: Food Chem., 114, 898 (2009), Grigat, S., et al.: Drug Metab. Disposition, 37, 330 (2009),

Alexidine dihydrochloride: antifungal, antibiofilm, targets PTPMT1 for mitochondrial apoptosis, potential cancer treatment.

Trifloxystrobin is a fungicide against R. solani in sugar beets with EC50s: 23.0 μg/L for Daphnia neonates, 1.7 μg/L for embryos.

Chlorothalonil (DAC 2787): Broad-spectrum, efficient, low-toxicity fungicide for fruits, vegetables, rice, wheat, cotton.

Oxiconazole is an anti-fungal agent that is used for the treatment of various dermatophyte infections. It can be used to treat athlete’s foot, ringworm and jock itch. This drug inhibits ergosterol biosynthesis and acts to destabilize the fungal cytochrome enzyme P450 51. Additionally, this drug has shown to inhibit DNA synthesis and suppress concentrations of ATP. Oxiconazole nitrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation.

MoTPS1-IN-1 is a potent MoTPS1 inhibitor with antifungal anti-inflammatory activity that acts through interaction with Glu396 study ulcerative colitis.

Camalexin: a phytoalexin from Camelina sativa with antifungal, antibacterial, anticancer properties and induces ROS.

Polygodial (Tadeonal) is an antifungal potentiator and an antibiotic, particularly against Saccharomyces cerevisiae, Candida utilis, and Sclerotinia libertiana.

Fosetyl-aluminum is a systemic fungicide that controls downy mildews and Phytophthora diseases, used on a variety of crops including fruits and vegetables。

Inhibitor of glucan synthase; antifungal compound

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

Triadimenol (UK 199) is a triazole fungicide that is cardiotoxic and promotes reactive oxygen species (ROS) production and apoptosis in zebrafish.

Miconazole is an antifungal drug that is used for the treatment of fungal infections. This drug has broad-spectrum activity and works by inhibiting fungal CYP450 14α-lanosterol demethylase activity. This leads to altered ergosterol production and an impaired cell membrane. Miconazole nitrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.