Antimicrobianos

Broad-spectrum antibiotic; bacterial cell wall biogenesis inhibitor

Selective and potent inhibitor of sialidases (neuraminidases) in influenza A and B viruses. The compound binds tightly to the viral neuraminidase active site in late stages of viral life-cycle. It inhibits shedding sialic acids from host cell surface glycans, which interact with viral hemagglutinin, and consequently prevents release of new viral particles from the host cell surface.

Please enquire for more information about N-(4-Hexylphenyl)-5-nitro-2-furancarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating gynecological and obstetric infections.

Bromobutide-desbromo is a chemical compound that functions as a selective herbicide. It is derived from synthetic sources and is specifically formulated to interfere with photosynthesis in target plants. The mode of action of bromobutide-desbromo involves inhibiting photosystem II, a crucial component of the photosynthetic electron transport chain in plants. This inhibition disrupts the energy conversion process, leading to a decrease in ATP and NADPH production, which are essential for plant growth. Bromobutide-desbromo is primarily utilized in agricultural settings to manage and control the growth of unwanted broadleaf and grassy weeds. Its application is critical in optimizing crop yields by reducing competition for nutrients, light, and space. With its selective action, this compound targets undesirable vegetation with minimal impact on the surrounding non-target plants, offering a precise and effective weed management solution. As an expert scientist, understanding the specific interactions and efficacy of bromobutide-desbromo will facilitate the development of sustainable agricultural practices and contribute to integrated weed management strategies.

Pentosan polysulfate is a semi-synthetic polysaccharide, which is derived from xylan, sourced from beechwood hemicellulose. It functions as a heparin-like compound with anticoagulant and fibrinolytic properties. Its sulfated polysaccharide form allows it to adhere to the urothelium of the bladder, forming a protective layer that can prevent irritating solutes in urine from reaching bladder cells. Through this mechanism, it mitigates the pain and discomfort associated with interstitial cystitis (IC), a chronic condition characterized by bladder pain and urinary urgency. The primary use of pentosan polysulfate is in the management of interstitial cystitis, where its ability to restore defects in the bladder's glycosaminoglycan layer provides symptomatic relief. Additionally, it has shown potential in addressing certain other conditions, such as osteoarthritis, due to its anti-inflammatory properties, although these applications require further research for clinical validation. As a pharmaceutical agent, it is crucial in offering a therapeutic option to improve the quality of life for patients with chronic urinary bladder disorders.

Applications Pentachlorophenol-13C6 is the labeled form of Pentachlorophenol (P238100), which is used as insecticide for terminate control; pre-harvest defoliant; general herbicide. Antimicrobial preservative and fungicide for wood, wood products, starches, textiles, paints, adhesives, leather, pulp, paper, industrial waste systems, building materials. Surface disinfectant.This compound is a contaminant of emerging concern (CECs). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),

Aminosidine is a nucleoside analogue that inhibits the HIV-1 reverse transcriptase and the integrase, which are enzymes involved in viral DNA synthesis. Aminosidine is active against Leishmania spp., but not against bacteria. Aminosidine has been shown to be effective in experimental models of human bowel disease and in patients with inflammatory bowel disease. It was also found to be active against wild-type strains of human immunodeficiency virus type 1, but not resistant mutants. The mechanism of action is the inhibition of cellular mitochondrial membrane potential.

Inhibitor of protein synthesis; aminoglycoside

Ofloxacin Q acid is a quinolone analog, which is a synthetic derivative known for its significant antibacterial properties. This compound is sourced from the chemical synthesis of fluoroquinolone derivatives, designed to enhance reactivity and efficacy in pharmaceutical applications. Ofloxacin Q acid acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, and repair, thereby leading to the cessation of bacterial growth and replication. The primary usage of Ofloxacin Q acid is in the development and study of antibacterial agents. Its capacity to inhibit crucial bacterial enzymes makes it an essential component in the research and development of therapies aimed at treating bacterial infections. The compound's stability under acidic conditions and its ability to resist bacterial mutations further emphasize its potential as a subject in pharmaceutical research. This makes Ofloxacin Q acid a valuable tool in understanding bacterial resistance mechanisms and designing next-generation antibacterial drugs.

Applications (4bS)-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol is a naturally occurring diterpene that exhibits potent antimicrobial activity. References Tian, M., et al.: Records of Natural Products, 14, 219 (2020)

Omomycin is a novel antibiotic, specifically a macrolide, which is derived from microbial sources, primarily soil-dwelling actinomycetes. Its mode of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This interaction prevents the translocation of peptides during translation, thereby halting bacterial growth and proliferation. The primary uses and applications of Omomycin are in the treatment of multi-drug resistant bacterial infections, particularly those caused by Gram-positive pathogens such as Staphylococcus aureus and Streptococcus pneumoniae. It has shown efficacy in overcoming resistance associated with traditional antibiotics and has been studied for its potential role in addressing healthcare-associated infections. The ongoing development and research into Omomycin focus on its pharmacokinetics, dosing regimens, and long-term safety profile in various clinical settings.

Please enquire for more information about Fosmidomycin sodium hydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Validamycin E is an antifungal antibiotic, which is a secondary metabolite derived from the actinobacterium Streptomyces hygroscopicus. Its mode of action involves the inhibition of trehalase, an enzyme crucial for the hydrolysis of trehalose into glucose, disrupting essential energy pathways in fungi. By inhibiting trehalase, Validamycin E effectively interferes with the growth and development of fungal pathogens. This compound is primarily used in agriculture to control and manage plant diseases caused by pathogenic fungi, such as Rhizoctonia solani. It is particularly employed in crops like rice, vegetables, and fruit trees, where it helps in mitigating the impact of fungal infections on productivity and crop quality. Validamycin E's specific action against trehalase ensures a targeted approach, reducing the risk of harmful effects on non-target organisms, making it an invaluable tool in integrated pest management systems. Its application contributes to sustainable agricultural practices, supporting both the protection of crops and the preservation of ecological balance.

Anti-fungal; sterol demethylase inhibitor

3-(2-(2,4-Dichlorophenyl)-2-hydroxyethyl)-3,4-imidazolidinedione is a synthetic compound, which is a derivative of imidazolidinedione. It is primarily characterized as an antifungal agent with broad-spectrum activity against various fungal species. Its mode of action involves disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately, cell death. The efficacy of this compound is attributed to its ability to inhibit the growth of pathogens by targeting critical pathways necessary for fungal survival. Used extensively in the field of medicinal chemistry, its applications include the treatment of fungal infections in both clinical and agricultural settings. This compound's selectivity for fungal cells, while sparing mammalian cells, underscores its significance in developing antifungal therapies. Researchers continue to explore its potential in addressing drug-resistant fungal strains, making it a subject of ongoing study within pharmaceutical and agricultural research domains.

Applications β-Costol is a component in essential oil from plant extract and exhibits antibacterial and antifungal activities References Suleimen, E.M., et al.: Chem. Natural Compds., 55, 154 (2019);Doungchawee, J., et al.: Chemistry and Biodiversity, 16, (2019);Gandhi, A.S., et al.: Am. J. Pharm.Tech. Res., 8, 189 (2018);

BMS 806 is used as an anti-viral agent. It has been shown to inhibit the replication of HIV. BMS 806 inhibits viral life by binding to the surface glycoproteins and inhibiting viral entry into cells. The drug also inhibits viral replication by preventing DNA transcription and translation. BMS 806 is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Gentamicin B is an aminoglycoside antibiotic, which is derived from the bacterium Micromonospora. This derivative exhibits its mode of action by binding to the 30S subunit of the bacterial ribosome, disrupting protein synthesis. As a result, it causes misreading of mRNA, ultimately leading to cell death, thereby exhibiting bactericidal effects. Gentamicin B is commonly employed in the treatment of serious infections caused by Gram-negative bacteria, including Pseudomonas, Klebsiella, and Escherichia coli. It is particularly useful in healthcare settings for severe systemic infections, such as those affecting the respiratory tract, urinary tract, skin, and soft tissues. Due to its potent activity, it is often reserved for situations where other antibiotics might be ineffective. Additionally, its use is monitored carefully to avoid potential nephrotoxicity and ototoxicity, common side effects associated with aminoglycosides. Thus, Gentamicin B plays a critical role in the antibiotic arsenal, particularly in hospital settings dealing with resistant bacterial strains.

Virginiamycin - Complex of M1+S1 is an antibiotic compound, which is derived from the actinobacterium Streptomyces virginiae. It functions through the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby obstructing peptide bond formation and impeding microbial growth. The complex is composed of two major components: Virginiamycin M1 and Virginiamycin S1, which synergistically enhance antimicrobial efficacy. In scientific applications, Virginiamycin is utilized extensively as a growth promoter in livestock, owing to its ability to improve feed efficiency and weight gain. It is also employed in veterinary medicine to treat and prevent infections caused by Gram-positive bacteria, including some resistant strains. Additionally, its use extends to industrial fermentation processes as an agent to maintain selective conditions and enhance yield. Despite its benefits, the rise of antibiotic resistance necessitates careful management of Virginiamycin usage to mitigate potential impacts on human health.

Steffimycin B is an anthracycline antibiotic, which is a metabolite produced by certain Streptomyces species. This compound functions by intercalating into DNA, thereby inhibiting the synthesis of nucleic acids and disrupting essential cellular processes. Its mode of action involves preventing the replication and transcription of bacterial DNA, leading to cell death. Steffimycin B has been primarily explored for its antibiotic properties, particularly in research settings for its potential to combat specific bacterial infections. Additionally, its structural similarities to other anthracyclines suggest potential use in studying mechanisms of drug resistance and interactions with DNA. Further investigation may reveal additional therapeutic applications or synergistic effects in combination with other antimicrobial agents.

Sulfadiazine is a sulfonamide antibiotic with action on bacterial folate synthesis inhibition and is used for treating toxoplasmosis and urinary tract infections.

Applications Anti-infective (topical). Antimicrobial.Environmental contaminants; Food contaminants; Heat processing contaminants References Morris, et al.: Cancer Res., 29, 2145 (1969), Sanderson, H., et al.: Toxicol. Lett., 144, 383 (2003),

Apramycin sulfate is a semisynthetic antibiotic that inhibits the growth of Gram-negative bacteria. It is a sulfonamide and has been used in clinical isolates to treat bacterial infections. Apramycin sulfate inhibits the biosynthesis of folic acid, which is important for DNA synthesis and cell division. It also inhibits the production of RNA by binding to ribosomes and inhibiting protein synthesis. Apramycin has been shown to have anticancer properties as well, with studies showing that it can inhibit tumor growth in vitro and in vivo.

Gentamicin C1a pentaacetate is an aminoglycoside antibiotic derivative, which is synthesized through the acetylation of the hydroxyl groups in gentamicin C1a. This compound is derived from the fermentation products of Micromonospora species, a genus of actinobacteria. Its mode of action is similar to that of standard aminoglycosides, primarily involving the binding to bacterial 30S ribosomal subunits. This binding interferes with protein synthesis by causing misreading of mRNA, ultimately leading to the inhibition of protein production and bacterial cell death. In scientific research, Gentamicin C1a pentaacetate is utilized in studies focusing on antibiotic resistance mechanisms, structure-activity relationships, and the development of new derivative antibiotics. Its modified structure offers opportunities to explore variations in bacterial susceptibility and efflux mechanisms. Understanding such interactions is vital for the design of potent antibiotic candidates and combating resistant bacterial strains. Given the growing concern over antibiotic resistance, studies involving Gentamicin C1a pentaacetate contribute to a broader comprehension of aminoglycoside modifications and their potential applications in clinical and laboratory settings.

Inducer of apoptosis; translational inhibitor; aminonucleoside antibiotic

Rifaximin is a rifamycin antibiotic with action on bacterial RNA polymerase to inhibit transcription and is used for treating travelers' diarrhea, irritable bowel syndrome, and hepatic encephalopathy.

Homoembelin is a chemical compound that is classified as a natural product alkaloid, which is derived from specific plant sources, notably the fruit of the plant Embelia ribes. It operates through a variety of biochemical interactions at the molecular level, including the inhibition of specific enzymes and modulation of signaling pathways. This mode of action has garnered interest due to its potential effects in various therapeutic contexts. The uses and applications of Homoembelin have been a subject of scientific investigation, particularly in the areas of traditional medicine and pharmacology. Researchers are exploring its potential as an anti-inflammatory, antimicrobial, and anticancer agent. Consequently, it has been a topic of numerous studies seeking to understand its efficacy and safety profiles. The exploration of its modes of action and biological activities continues to provide insights into possible therapeutic applications, making it a compound of considerable interest within the scientific community.

Please enquire for more information about Aqabamycin F including the price, delivery time and more detailed product information at the technical inquiry form on this page

Descarbamylnovobiocin is a synthetic derivative of the antibiotic novobiocin, which is originally sourced from Streptomyces species. As a derivative, it modifies certain structural elements of the parent compound to potentially enhance or alter its antimicrobial properties. Its mode of action is primarily through the inhibition of bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and cell division. By impeding these enzymes, descarbamylnovobiocin disrupts the supercoiling of bacterial DNA, thereby inhibiting bacterial growth and proliferation. Due to its activity against a range of Gram-positive bacteria, including resistant strains, descarbamylnovobiocin is primarily used in research settings to study bacterial resistance mechanisms and the development of new antibacterial agents. It provides a valuable tool for understanding the nuances of antimicrobial activity and resistance, aiding the development of next-generation antibiotics. Its applications are critical in microbiology and pharmacology research, where understanding resistance mechanisms and finding alternative therapeutic pathways are ongoing scientific challenges.

Aureothricin is a dithiolopyrrolone antibiotic and is used for its antimicrobial properties. It inhibits transcription in bacteria, leading to growth inhibition

Fosravuconazole L-lysine ethanolate is an antifungal prodrug, which is a derivative of the widely used antifungal agent ravuconazole. This compound is synthesized through chemical modification to enhance its bioavailability and aqueous solubility, addressing limitations found in its parent compound. Fosravuconazole is designed to undergo in vivo conversion to ravuconazole, its active form, by enzymatic processes within the body. Fosravuconazole L-lysine ethanolate exhibits potent antifungal activity through its mechanism of inhibiting the enzyme lanosterol 14α-demethylase (CYP51). This enzyme is crucial in the biosynthesis of ergosterol, an essential component of fungal cell membranes. Inhibition of this pathway results in impaired cell membrane formation and, ultimately, cell death. The primary use of Fosravuconazole L-lysine ethanolate is in the treatment of various systemic fungal infections, particularly those caused by Candida and Aspergillus species. It is researched for its use in both immunocompromised and non-immunocompromised patients, highlighting its potential in treating invasive mycoses with a favorable safety profile.

Please enquire for more information about Hsv-tk substrate including the price, delivery time and more detailed product information at the technical inquiry form on this page