Antimicrobianos

Broad-spectrum antibiotic; bacterial cell wall biogenesis inhibitor

Selective and potent inhibitor of sialidases (neuraminidases) in influenza A and B viruses. The compound binds tightly to the viral neuraminidase active site in late stages of viral life-cycle. It inhibits shedding sialic acids from host cell surface glycans, which interact with viral hemagglutinin, and consequently prevents release of new viral particles from the host cell surface.

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Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating gynecological and obstetric infections.

Bromobutide-desbromo is a chemical compound that functions as a selective herbicide. It is derived from synthetic sources and is specifically formulated to interfere with photosynthesis in target plants. The mode of action of bromobutide-desbromo involves inhibiting photosystem II, a crucial component of the photosynthetic electron transport chain in plants. This inhibition disrupts the energy conversion process, leading to a decrease in ATP and NADPH production, which are essential for plant growth. Bromobutide-desbromo is primarily utilized in agricultural settings to manage and control the growth of unwanted broadleaf and grassy weeds. Its application is critical in optimizing crop yields by reducing competition for nutrients, light, and space. With its selective action, this compound targets undesirable vegetation with minimal impact on the surrounding non-target plants, offering a precise and effective weed management solution. As an expert scientist, understanding the specific interactions and efficacy of bromobutide-desbromo will facilitate the development of sustainable agricultural practices and contribute to integrated weed management strategies.

Pentosan polysulfate is a semi-synthetic polysaccharide, which is derived from xylan, sourced from beechwood hemicellulose. It functions as a heparin-like compound with anticoagulant and fibrinolytic properties. Its sulfated polysaccharide form allows it to adhere to the urothelium of the bladder, forming a protective layer that can prevent irritating solutes in urine from reaching bladder cells. Through this mechanism, it mitigates the pain and discomfort associated with interstitial cystitis (IC), a chronic condition characterized by bladder pain and urinary urgency. The primary use of pentosan polysulfate is in the management of interstitial cystitis, where its ability to restore defects in the bladder's glycosaminoglycan layer provides symptomatic relief. Additionally, it has shown potential in addressing certain other conditions, such as osteoarthritis, due to its anti-inflammatory properties, although these applications require further research for clinical validation. As a pharmaceutical agent, it is crucial in offering a therapeutic option to improve the quality of life for patients with chronic urinary bladder disorders.

Applications Pentachlorophenol-13C6 is the labeled form of Pentachlorophenol (P238100), which is used as insecticide for terminate control; pre-harvest defoliant; general herbicide. Antimicrobial preservative and fungicide for wood, wood products, starches, textiles, paints, adhesives, leather, pulp, paper, industrial waste systems, building materials. Surface disinfectant.This compound is a contaminant of emerging concern (CECs). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),

Aminosidine is a nucleoside analogue that inhibits the HIV-1 reverse transcriptase and the integrase, which are enzymes involved in viral DNA synthesis. Aminosidine is active against Leishmania spp., but not against bacteria. Aminosidine has been shown to be effective in experimental models of human bowel disease and in patients with inflammatory bowel disease. It was also found to be active against wild-type strains of human immunodeficiency virus type 1, but not resistant mutants. The mechanism of action is the inhibition of cellular mitochondrial membrane potential.

Inhibitor of protein synthesis; aminoglycoside

Ofloxacin Q acid is a quinolone analog, which is a synthetic derivative known for its significant antibacterial properties. This compound is sourced from the chemical synthesis of fluoroquinolone derivatives, designed to enhance reactivity and efficacy in pharmaceutical applications. Ofloxacin Q acid acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, and repair, thereby leading to the cessation of bacterial growth and replication. The primary usage of Ofloxacin Q acid is in the development and study of antibacterial agents. Its capacity to inhibit crucial bacterial enzymes makes it an essential component in the research and development of therapies aimed at treating bacterial infections. The compound's stability under acidic conditions and its ability to resist bacterial mutations further emphasize its potential as a subject in pharmaceutical research. This makes Ofloxacin Q acid a valuable tool in understanding bacterial resistance mechanisms and designing next-generation antibacterial drugs.

Applications (4bS)-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol is a naturally occurring diterpene that exhibits potent antimicrobial activity. References Tian, M., et al.: Records of Natural Products, 14, 219 (2020)

Omomycin is a novel antibiotic, specifically a macrolide, which is derived from microbial sources, primarily soil-dwelling actinomycetes. Its mode of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This interaction prevents the translocation of peptides during translation, thereby halting bacterial growth and proliferation. The primary uses and applications of Omomycin are in the treatment of multi-drug resistant bacterial infections, particularly those caused by Gram-positive pathogens such as Staphylococcus aureus and Streptococcus pneumoniae. It has shown efficacy in overcoming resistance associated with traditional antibiotics and has been studied for its potential role in addressing healthcare-associated infections. The ongoing development and research into Omomycin focus on its pharmacokinetics, dosing regimens, and long-term safety profile in various clinical settings.

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