Antivirales

Isomyosmine inhibits nitrate reductase and reduces oxidative stress. Isomyosmine is used to study inflammation and virus infection related to oxidoreductase.

Applications Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir is an intermediate for the synthesis of Atazanavir (A790051) and the preparation of some peptide analogs. References Martin, J., et al.: Prog. Med. Chem., 32, 239 (1995), Jadhav, P., et al.: J. Med. Chem., 40, 181 (1997), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998);

Impurity USP Ribavirin Related Compound A Applications Ribavirin Carboxylic acid is an impurity of Ribavirin (R414475). Ribavirin impurity A. References Lertora, J., et al.: Clin. Pharmacol. Ther., 50, 442 (1991), Connor, E., et al.: Antimicrob. Agents Chemother., 37, 532 (1993), Manns, M., et al.: Lancet, 358, 958 (2001),

Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

(S)-HPMPA is a nucleotide analogue, which is a chemically synthesized compound designed to mimic nucleotides. It acts as both an antiviral and an antitumor agent, sourced primarily through synthetic chemistry involving the modification of naturally occurring nucleotide structures. The mode of action of (S)-HPMPA involves mimicking natural substrates of various viral polymerases and cellular enzymes, thereby inhibiting viral DNA synthesis and disrupting the replication cycle of DNA viruses. Additionally, it can interfere with certain cellular pathways contributing to its antitumor effects. The primary applications of (S)-HPMPA include research in virology, particularly focused on understanding viral replication mechanisms and developing new antiviral therapies. It has shown activity against a range of DNA viruses, including herpesviruses and cytomegaloviruses, and has potential uses in oncology as a supportive agent in antitumor research. The compound's ability to integrate into ongoing biochemical pathways provides valuable insights into enzyme-substrate interactions and cellular responses to analog interference, making it a significant tool in molecular biology and pharmaceutical research.

Stability Hygroscopic Applications Tenofovir (T018500) impurity.

PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .

Antiviral; nonpeptidic HIV-1 protease inhibitor