Iridioides

Globularin is a naturally occurring bioactive compound, which is an iridoid glycoside sourced primarily from the plant family Plantaginaceae. Its mode of action involves modulation of specific cellular signaling pathways, demonstrating antioxidant, anti-inflammatory, and potential anti-cancer properties in various in vitro and in vivo studies. Globularin’s primary uses and applications are in the fields of pharmacology and biochemistry, where it is extensively researched for its therapeutic potential. It has shown promise in mitigating oxidative stress and associated cellular damage, making it a candidate for studies focused on neuroprotection and chronic inflammatory conditions. Additionally, preliminary research suggests its efficacy in modulating cell proliferation and apoptosis, positioning it as a compound of interest in cancer research. Its role in traditional medicine as a component of herbal extracts also underscores its historical significance and warrants further scientific exploration.

Natural glycoside

Natural glycoside

Natural glycoside

Nuzhenide analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Loganin is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively. Loganin has neuroprotective, anti-amnesic, anti-inflammatory and anti-shock effects, it also exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation. Loganin can attenuate neuroinflammatory responses through the inactivation of NF-κB by NF-κB dependent inflammatory pathways and phosphorylation of MAPK in Aβ25-35-induced PC12 cells, and can protect against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells.

Euphroside is a bioactive glycoside, which is a compound derived from natural sources, typically found in certain medicinal plants. Its chemical structure consists of a sugar moiety bound to a non-sugar component, which influences its pharmacological activity. The mode of action of Euphroside is not fully elucidated, but it is believed to interact with biological pathways involving oxidative stress and inflammatory responses. This action is hypothesized to modulate cellular processes and physiological functions, potentially offering therapeutic benefits. Euphroside is primarily studied for its possible applications in biomedical and pharmacological fields, including anti-inflammatory and antioxidant therapies. Its potential to mitigate oxidative stress makes it a subject of interest for researchers looking into treatments for chronic diseases characterized by inflammation and cellular damage. Additionally, Euphroside might hold promise for further exploration in other therapeutic areas, depending on ongoing research outcomes. Its efficacy and safety are under continuous investigation, with a focus on understanding the underlying mechanisms and identifying possible clinical applications.

Catalposide is a bioactive iridoid glycoside, which is a naturally occurring compound sourced from various plant species, including those in the family Bignoniaceae. This compound is primarily extracted from the roots, leaves, and flowers of plants such as Catalpa and Rehmannia species. Catalposide exhibits its effects by modulating various cellular pathways, including the inhibition of pro-inflammatory cytokines and the modulation of oxidative stress mechanisms. Its mode of action involves the suppression of NF-kB activation and interference with inflammatory signaling cascades. The compound's potent anti-inflammatory and antioxidative properties make it of significant interest in the field of pharmacology and medicine. Catalposide is studied for its potential therapeutic applications in managing conditions such as arthritis, cardiovascular diseases, and neurodegenerative disorders. Its capability to mitigate oxidative stress also positions it as a promising candidate for research in aging-related diseases and conditions that require the protection of cellular components from oxidative damage.