Iridioides

Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata , reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling; stimulation of the endogenous β-endorphin expression may be a novel and effective strategy for the discovery and development of analgesics for the long-term treatment of chronic pain.

Natural glycoside

Shanziside suppresses immune system; notably reduces IL-2 in activated human T cells.

Shanzhiside is a bioactive compound, specifically an iridoid glycoside, derived from the fruit of the Gardenia jasminoides Ellis. This product originates from a traditional medicinal plant, long recognized in Eastern medicine for its therapeutic properties. Shanzhiside acts primarily through its anti-inflammatory and antioxidant activities, modulating pathways that contribute to oxidative stress and inflammation in cells. These actions offer neuroprotective effects, making it a subject of interest in neuroscience research. The applications of Shanzhiside are particularly focused on its potential in treating neurodegenerative diseases, such as Alzheimer's and Parkinson's. Research indicates that its ability to mitigate oxidative damage and inflammation in neuronal tissues can contribute to slowing or preventing the progression of these conditions. Further exploration of its pharmacokinetics and molecular interactions in neuronal pathways continues, as it presents a promising avenue for therapeutic development.

Natural glycoside

Valtrate analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Catalpol, an iridoid glucoside, has been reported to inhibit apoptosis of neuron and endothelial cells; the pretreatment of H9c2 cells with catalpol can be against H 2 O 2 -induced apoptosis, and the protective effect of catalpol involves the mitochondrial-dependent caspase pathway and is associated with increased Bcl-2 and decreased Bax expression.