Cannabinoides

Impurity Paracetamol EP Impurity H/ Acetaminophen impurity H Applications Acetaminophen Acetate is an impurity of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.

AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.

Applications (E)-1-(3,5-Bis(benzyloxy)phenyl)pent-1-en-3-ol is a reagent in the synthesis of 3''-Hydroxycannabidiol (H824825) which is a major constituents in marijuana. 3''-Hydroxycannabidiol be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol. References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)

CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.

Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90.

Applications JWH-007 is a novel cannabinoid receptor agonist at both the CB1 and CB2 receptors. Synthetic cannabinoids References Pertwee, R.G., et al.: Euro. J. Pharmacol., 284, 241 (1995); Wiley, J.L., et al.: J. Pharmacol. Experiment. Therap., 285, 995 (1998);

Applications RCS-4 is a synthetic JWH 018 cannabinoid analog that has been identified as a component of several different ‘herbal incense’ products. Synthetic Cannabinoids References Gandhi, A., et al.: Bioanalysis, 6, 1471 (2014);

Applications 1-Butanol is a common chemical reagent used in biodiesel production. Also it has been used in the study the polarization of vapor-deposited 1-butanol films (1) as well as in the preparation of bioavailable CB1 antagonists (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Gavra, I. et al.: J. Chem. Phys. 2017 Mar 14;146(10):104701.2. Röver, S. et al.: J. Med. Chem. 2013 Dec 27;56(24):9874-96.