Azúcares troncales y bases nucleicas

Please enquire for more information about 2-Chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-6-phenylpurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cy3.5 diacid, SE is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.

Please enquire for more information about 6-(2-Hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3’-beta-Azido-2’,3’-dideoxy-5’-O-(4-methoxytrityl)-5-fluorouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5,6-Diamino-1,3-dimethyl uracil hydrate is a purine derivative that inhibits the growth of cancer cells by blocking the enzyme ribonucleotide reductase. This leads to a decrease in DNA synthesis, protein synthesis, and cell division. The anticancer activity of 5,6-Diamino-1,3-dimethyl uracil hydrate is due to its ability to inhibit the formation of ATP and the GTP cycle. It also has a potent inhibitory effect on the structural analysis of DNA and RNA. 5,6-Diamino-1,3-dimethyl uracil hydrate has been shown to produce apoptotic effects in many types of cancer cells. This drug also has specific agonist properties for G protein coupled receptors that are responsible for activating apoptosis.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(4-nitrobenzyl)uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-(Dimethylamino)guanosine (cas# 2140-67-2) is a compound useful in organic synthesis.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-allyl-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Fluorouridine Diphosphate Glucose (5-FdG-Glc) is a fluorinated analogue of uridine 5'-monophosphate. It is used as an analytical tool to study tumor metastases and to analyze the effects of different substances on the cell's metabolism. The enzyme activities of phosphatase and anabolic enzymes are potentiated by 5-FdG-Glc, which has been shown to be effective in inhibiting cancer cells and microorganisms. 5-FdG-Glc can also be used for the detection of p-nitrophenyl phosphate, which is a product of lipid peroxidation in cells.

Applications Adenine Hydrochloride can be utilized in uses for enhanced detection of hydrogen peroxide with platinized microelectrode arrays for analyses of mitochondria activities. It can also be used for biological use in method for producing Cordyceps sinesis by fermentation. References Ben-Amor, S., et al.: Electrochim. Acta., 126, 171-178 (2014); Jia, J., et al.: Faming Zhuanli Shenqing, CN 101407767 A 20081117 (2008);

N4-Acetylcytosine is an inhibitor of serine proteases, glycosidases and nucleosidases. It has been shown to inhibit the replication of a wide range of viruses including HIV, herpes simplex virus type 1, and adenovirus. N4-Acetylcytosine also inhibits the proliferation of cervical cancer cells.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(2-methoxy)ethyl-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Fluoro-1-(2'-Fluoro-2'-Deoxyribofuranosyl)Uracil (5FU) is a pyrimidine analog that is used in the treatment of cancer. It is usually given intravenously to patients with metastatic colorectal cancer. 5FU is an inhibitor of thymidylate synthase and dihydrofolate reductase, which are enzymes involved in DNA synthesis. The drug also inhibits the production of uracil, which results in the inhibition of RNA synthesis and protein synthesis. This leads to tumor cell death by apoptosis or necrosis. 5FU also has been shown to have a direct cytotoxic effect on lung tumor cells, as well as other analogues such as 2'-fluoro-5-methyl-4(3H)-pyrimidinone and 5,5'-difluorouracil (5DFUR).

DMTr-4'-Me-U-CED-TBDMS phosphoramidite: dye for RNA labeling; useful in RNA therapy, aptamers, ribozymes. Store in dark.

Please enquire for more information about 5’-Methyl-4-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine (3DFT) is a nucleoside analogue of thymidine. It has been shown to be an efficient inhibitor of HIV replication in vitro and in vivo. 3DFT is able to inhibit virus production by blocking the viral reverse transcriptase enzyme, which is responsible for copying the viral genomic RNA into DNA. This drug also inhibits the activity of human immunodeficiency virus type 1 integrase, which is an enzyme that catalyses the integration of proviral DNA into host cell chromosomes. 3DFT is a potent inhibitor of HIV infection in vitro and in vivo and has also been shown to inhibit other viruses such as cytomegalovirus, herpes simplex virus types 1 and 2, varicella zoster virus, influenza A virus, coxsackie B4 virus, echovirus 7, and erythrovirus 9.

Please enquire for more information about 3’-Azido-3’-deoxy-4-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

8-Bromoadenine is a nucleophile that reacts with electrophiles to form adducts. 8-Bromoadenine has been shown to induce DNA strand breaks and oxidative damage in vitro, which may be due to its ability to react with DNA bases and form intramolecular hydrogen bonds. 8-Bromoadenine has also been shown to cause inflammatory bowel disease in mice by increasing the production of proinflammatory cytokines. 8-Bromoadenine induces Toll-like receptor 4 (TLR4) signaling, which leads to enhancement of radiation response. This drug can also be used as the monosodium salt for treating cancer, although it only has a limited number of sequences that can be synthesized.

Purine nucleobase; component of nucleic acids and coenzymes

2’-Amino-2’-deoxy-β-D-arabinouridine is a modified nucleoside based on uridine, in which the 2'-hydroxyl group of the sugar has been replaced with an amino group, and the sugar itself is arabinose (a stereoisomer of ribose). This compound is of possible interest in nucleic acid chemistry and antisense or RNA-interference research.

6-Amino-5-bromo-1-methyluracil monohydrate (6ABMU) is a purine analogue that has been shown to be a potent and selective inhibitor of the enzyme uracil phosphoribosyltransferase, which is involved in the synthesis of uridine monophosphate. 6ABMU has been used for research purposes and can be administered orally or intravenously. This drug also has been shown to increase the production of propylamine, an intermediate in the metabolism of methylated purines. The pharmacokinetics of 6ABMU have been studied in rats, mice, and humans and has been found to have a half-life of about one hour. Metrics such as the bioavailability and plasma protein binding have also been determined for this drug. Biostructural studies on 6ABMU have shown that it binds to proteins with high affinity and specificity; these proteins include protein-protein interactions such as those between rib

3’-O-t-Bulyldimethylsilyl thymidine is a nucleoside analog that is chemically stable and has been shown to be a potential biomarker for the diagnosis of fetal bovine spongiform encephalopathy (BSE). 3’-O-t-Bulyldimethylsilyl thymidine binds to basic proteins in the cell nucleus, which can be detected by immunoassay. It also has been shown to inhibit protein synthesis in tubule cells of the kidney and skin cancer cells. The drug is metabolized by dephosphorylation to t-butyldeoxyuridine, which is then converted into thymidine.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(2S)-[2-(tert-butoxy-carbonyl)amino-3-carbonyl]propyl-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

N2-Acetylguanine is a reactive compound that inhibits the growth of cancer cells in leukemia. It is an antimicrobial agent that has significant cytotoxicity against leukemia cells and other bacterial cells. N2-Acetylguanine reacts with dihydrozeatin to form acyclic nucleoside phosphonate, which inhibits the synthesis of DNA, RNA, and protein. This reaction yields a high yield of this product in a short period of time. The modification process also creates a more efficient method for synthesizing this compound. N2-Acetylguanine can be used to treat dyslipidemia by decreasing cholesterol levels in the blood and can also be used as an active substance in the treatment of diabetes mellitus type II and insulin resistance.

3'-Fluorothymidine-5'-triphosphate is a nucleotide analog that is a potent inhibitor of HIV and hepatitis B virus. It binds to the polymerase enzyme, preventing the synthesis of viral DNA. 3'-Fluorothymidine-5'-triphosphate has been shown to be toxic for human cells in culture. This toxicity is due to its ability to inhibit cellular protein synthesis by binding to ribonucleotide reductase, an enzyme required for DNA synthesis. 3'-Fluorothymidine-5'-triphosphate also inhibits transcription and replication of human mitochondrial DNA by binding to the transcription factor TFIIIA, which regulates RNA polymerase I activity.

Please enquire for more information about 6-Hydroxy-2-methoxy-7-deazapurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Methyl-6-methylaminouracil is a postulated intermediate in the synthesis of thymine.

Please enquire for more information about 3’-Azido-3’-deoxy-5-trifluoromethyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications N6-(2-Isopentenyl)adenine can be used in biological study for cytokinins stimulated expression of stress-related proteins and transcripts in Arabidopsis thaliana with isopentenyltransferase overexpression. References Skalak, J., et al.: J. Exp. Bot., 67, 2861-2873 (2016)

Guanine (2-Aminohypoxanthine) is a purine base that is a constituent of nucleotides occurring in nucleic acids.

Guanine sulfate is a salt that is found in human blood, urine, and other biological fluids. It is composed of the conjugate acid of guanine with sulfate ions. This compound has been used to study the effect of radiation on rat cardiomyocytes. Guanine sulfate has also been used as a substrate for studying the activity of enzymes bound to biological samples such as human serum and histidine. The optimum pH for guanine sulfate is 7.0-8.5, which can be achieved by adding sodium hydroxide or potassium hydroxide to water. Guanine sulfate has been shown to denature DNA in Streptococcus faecalis at high concentrations (pH 8).

Guanosine-2-Deoxy-2-Fluoro-D-Glucose Diphosphate Ester is a cell-free extract that inhibits the glycosylation of proteins. It is an analog of guanosine, which is a nucleotide and vitamin. The mechanism of action is through inhibition of the enzyme protein glycosylation, which prevents mannose from being converted to mannose phosphate. This inhibits the cycle that creates more sugar phosphates, which are needed for protein glycosylation. Guanosine-2-Deoxy-2-Fluoro-D-Glucose Diphosphate Ester has been shown to inhibit growth in cell culture at concentrations of 0.1 mM.

(S)-HPMPA is a nucleotide analogue, which is a chemically synthesized compound designed to mimic nucleotides. It acts as both an antiviral and an antitumor agent, sourced primarily through synthetic chemistry involving the modification of naturally occurring nucleotide structures. The mode of action of (S)-HPMPA involves mimicking natural substrates of various viral polymerases and cellular enzymes, thereby inhibiting viral DNA synthesis and disrupting the replication cycle of DNA viruses. Additionally, it can interfere with certain cellular pathways contributing to its antitumor effects. The primary applications of (S)-HPMPA include research in virology, particularly focused on understanding viral replication mechanisms and developing new antiviral therapies. It has shown activity against a range of DNA viruses, including herpesviruses and cytomegaloviruses, and has potential uses in oncology as a supportive agent in antitumor research. The compound's ability to integrate into ongoing biochemical pathways provides valuable insights into enzyme-substrate interactions and cellular responses to analog interference, making it a significant tool in molecular biology and pharmaceutical research.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-tetrahydrofurfuryluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Amino-5-nitroso-3-methyluracil is an aromatic compound that belongs to the class of nitrogenous bases. It is a crystalline solid that can be obtained through dehydration of 6-amino-5-nitrosohydantoin, which is also known as 5,6-diaminopyrimidine. This substance has an anionic charge in the ligand form and a hydrated form. It reacts with piperidine to produce piperidinium ions. 6-Amino-5-nitroso-3-methyluracil has been shown to exist in two forms: neutral and exocyclic. The neutral form is more stable than the exocyclic form, which exhibits intramolecular hydrogen bonding.

Please enquire for more information about 2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-flluoro-3-deazauridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei.

6-Amino-1,3-dibutyluracil is a stabiliser that binds to chlorine and prevents its degradation by the polyene. It is also used in the lab as a stabiliser in organic chemistry. 6-Amino-1,3-dibutyluracil has been shown to inhibit the oxidation of uracil to form enaminones and eliminate hydrogen peroxide. The average molecular weight of 6-amino-1,3-dibutyluracil is 238.2 g/mol.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl) amino]propyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Thymidylyl-(3'-5')-2'-Deoxy-5-Fluorouridine is a thymidine analogue that is chemically synthesized, and has been shown to be non-toxic to animal cells. This drug has been used to study the effect of thymidine on cell culture viability. Thymidylyl-(3'-5')-2'-Deoxy-5-Fluorouridine may also have therapeutic potential for the treatment of cancer in humans.

Please enquire for more information about 9-Ethyl-d5-adenine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7-Bromo-6-chloro-7-deazapurine including the price, delivery time and more detailed product information at the technical inquiry form on this page