Azúcares troncales y bases nucleicas

Pyrimidine nucleobase; component of nucleic acids

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N7-((2-Hydroxyethoxy)methyl)guanine is a reagent, a complex compound, and a useful intermediate that is used in the manufacture of speciality chemicals. N7-((2-Hydroxyethoxy)methyl)guanine is also a versatile building block that has been shown to be effective in reactions involving the synthesis of N-heterocyclic carbene ligands.

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Applications 5,6-Dimethylthiouracil is a heterocyclic building block.

O6-alkylguanine-DNA alkyltransferase inhibitor

N6-Methyladenine is a modification of adenine in DNA. It is formed by the methylation of the N6 position of adenine, which is a group P2 purine base. The structural analysis of this compound has been studied using x-ray diffraction data, and it has been found that it may inhibit cancer cells by modifying their DNA. This compound can also be used as an antimicrobial agent to treat infections caused by eukaryotes such as bacteria and fungi. N6-Methyladenine may be useful in transcriptional regulation and cellular transformation.

ICG-carboxylic acid, NIR fluorescent probe, absorbs at 800 nm for medical imaging and heat release. Derived from ICG dye.

Applications An intermediate in the preparation of thymidine derivatives References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),

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Applications 8-Benzyloxy-2’-deoxyguanosine (cas# 96964-90-8) is a compound useful in organic synthesis. References Wang, Y., et al.: Chem. Res. Toxicol., 19, 837 (2006),

5-Ethyl-2-thiouracil (5ET) is an inhibitor of uridine phosphorylase and inhibits the synthesis of uridine. It has been shown to inhibit muscle tissue, which may be due to its inhibition of 5'-nucleotidase. 5ET has also been shown to have antitumor activity against Toxoplasma in mice and is oriented with a mass spectrometric detection. The disulfonate group of 5ET has been shown to inhibit the enzyme's activity in a linear range from 0.3 mM to 10 mM, while the methyl ester group is active at concentrations below 0.1 mM. Studies have found that 5ET inhibits the kinetics of uridine phosphorylase by binding to the enzyme's active site, preventing substrate binding and catalysis.

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5,6-Dihydrouracil is a model system and a drug that belongs to the class of inhibitors. It inhibits DNA polymerase, RNA polymerase, and other enzymes by binding to their active sites. 5,6-Dihydrouracil has been shown to inhibit hydrogen bonding interactions with the DNA template or matrix effect in vitro. This drug has also been shown to have an effect on energy metabolism in humans. 5,6-Dihydrouracil is used as a probe for enzyme activity and receptor binding studies in vitro. Additionally, it can be used as an analytical method for determining the presence of dihydrouracil in human serum.

Thiazole Orange is a dye that can be used for reticulocyte analysis.

9-Propenyladenine is a natural product that is an extractant and organic solvent. It has been shown to have protein synthesis inhibition activity against the ribosomal subunit. 9-Propenyladenine also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 9-Propenyladenine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

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