Nucleósidos

Incorporated in DNA/RNA hybrids and mismatch pairs to analyse helix stability

3'-Deoxy-N6-lauroyladenosine is a nucleoside analog that is used to treat cancer. It is a phosphoramidite compound and it has been shown to be highly active against cancer cells. 3'-Deoxy-N6-lauroyladenosine is an antiviral agent that inhibits viral DNA synthesis by competing with the natural substrate, deoxyribonucleosides, for incorporation into the growing DNA chain. It also prevents the replication of RNA viruses by inhibiting their transcription and translation processes. 3'-Deoxy-N6-lauroyladenosine also inhibits inflammation in the body and may act as a chemotherapeutic agent in other diseases such as diabetes, Alzheimer's disease, and Parkinson's disease.

ATP is an important molecule in the body that is involved in a number of cellular processes, including energy production and transmission. It has been shown to be tumorigenic and is found at high levels in plasma membranes and muscle cells. ATP binds to the adenylate cyclase enzyme in the cell membrane and stimulates its activity, which increases intracellular levels of cyclic AMP (cAMP). Cyclic AMP activates protein kinase A, which phosphorylates proteins, leading to a cascade of reactions that result in cellular changes. ATP also has pharmacological effects on the plasma membrane by increasing its permeability to certain ions such as potassium ions. This leads to an increase in the rate of depolarization of the cell membrane, which causes an influx of calcium ions into the cell.

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N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoyladenosine 3'-CE phosphoramidite is a novel antiviral nucleoside that has been modified to be more resistant to enzymatic degradation. This nucleoside is synthesized as a high purity, high quality DNA synthon. It is an activator of viral RNA polymerase and inhibits the synthesis of viral DNA, which prevents replication of the virus. N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoyladenosine 3'-CE phosphoramidite has also shown anticancer activity in preclinical studies.

5'-O-DMT-N2-Isobutyryl-2'-O-(2-methylacetamido)guanosine 3'-CE phosphoroamidite is a high purity, modified phosphoramidite that is used as an activator for the synthesis of DNA. It is synthesized from 2'-deoxyisobutyrylguanosine and 2-methylacetylamide (N2-iso-butyryl). 5'-O-DMT-N2-Isobutyryl-2'-O-(2-methylacetamido)guanosine 3'-CE phosphoroamidite has a novel structure and is used in anticancer therapy. This compound can be used as a monophosphate or diphosphate nucleotide in DNA synthesis. 5'-O-DMT-N2-Isobutyryl - 2'- O-(2 - methylacetamido)

An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.

1,5-Anhydro-3-O-benzoyl-4,6-O-benzylidene-2-deoxy-2-(uracil-1-yl)-D-altrohexitol is a nucleoside that is used in the synthesis of DNA. It has antiviral and anticancer properties.

1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil is a synthetic nucleoside that is activated by phosphorylation. This nucleoside is an antiviral and anticancer agent, and has been shown to be active against HIV, cytomegalovirus, herpes simplex virus type 1, and lymphocytic leukemia cells. It has also been shown to have anti-inflammatory properties. The compound is a monophosphate and diphosphate, which are more potent than the corresponding ribonucleosides. 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil has CAS number 26582, high purity, high quality.

N4-Benzoyl-5'-O-Trityl-cytidine (NBT) is a nucleoside that occurs in two forms: diphosphate and monophosphate. It is used as an activator of DNA and RNA synthesis, and as an antiviral agent. NBT has been shown to inhibit the replication of herpes simplex virus type 1, vaccinia virus and influenza virus in cell culture. It also inhibits the reverse transcriptase activity of HIV in vitro. NBT is a novel deoxyribonucleoside phosphoramidite, which can be used in the synthesis of oligodeoxyribonucleotides for use in DNA sequencing or gene cloning applications.

5-Formyl-2'-O-methylcytidine is a molecule that is involved in cellular processes such as DNA methylation, the addition of a methyl group to the 5 position of a cytosine residue. It has been shown to be an important epigenetic regulator and can be used as a strategy to treat tuberculosis. 5-Formyl-2'-O-methylcytidine is synthesized from guanine, which undergoes conversion into cytosine via enzymatic modification. This process is catalyzed by methyltransferase enzymes and it is usually carried out with S-adenosylmethionine (SAM) as the methyl donor. The product then converts back into guanine through deamination, which can be catalyzed by either adenine phosphoribosyltransferase or adenylate kinase.

2'-Bromo-2'-deoxyuridine is a synthetic nucleoside analog of deoxyuridine, in which the 2'-hydroxyl group of the ribose sugar is replaced with a bromine atom (Br) at the 2' position. This modification allows it to be incorporated into DNA during DNA synthesis, where it can replace the normal thymidine. This molecule can potentially be used in molecular biology and cell biology as a thymidine analog to study DNA replication, cell proliferation, and DNA repair.

aATP is useful in molecular biology applications including PCR/qPCR, reverse transcription, DNA labelling and DNA sequencing.

Second messenger in intracellular signal transduction

7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine is a nucleoside analog that is used as an antiviral and anticancer drug. It has also been shown to have antimalarial activity. 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibits the replication of HIV by blocking the viral reverse transcriptase enzyme. This drug is a phosphoramidite monophosphate with a purity of 99%.

Anti-viral; reverse transcriptase inhibitor

2'-O-Me-5'-O-DMT-1,3-di-N-POM-pseudouridine-3'-CE phosphoramidite is an antiviral agent that inhibits the synthesis of RNA. It has been shown to inhibit the production of new viruses in cultured cells and to be active against some strains of influenza virus. The modification was developed by chemists at Boehringer Ingelheim, who have also synthesised other novel nucleosides that are being tested as anticancer agents. This product is a monophosphate derivative with a high purity level and a CAS number.

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a novel phosphoramidite. It is modified with p-nitrophenyl carbonyloxy group at the 3' position of the uracil moiety. This phosphoramidite has antiviral activity against Hepatitis C and HIV. It also has anticancer activity in vitro and in vivo. 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a nucleoside that can be used for DNA synthesis or as a monophosphate or diphosphate for RNA synthesis. It is synthesized from deoxy

Cytidine hemisulfate salt is a postulated inhibitor of the blood group antigen. It inhibits the phosphatase activity of blood group-specific phosphatases, which may be caused by its specific inhibition of α-tocopherol and phenolphthalein. Cytidine hemisulfate salt has been shown to inhibit both adenylic and uridylic phosphatases, but does not inhibit other phosphatases. This drug is also an antigen that can stimulate B cells, which produce antibodies against it. Cytidine hemisulfate salt is found in DNA and RNA.