Beta-bloqueante

Heterocyclic compounds with oxygen hetero-atom(s) only

Labetalol hydrochloride (Sch-15719W), a salicylamide derivative, is a non-cardioselective blocker of β-adrenergic receptors and α1-adrenergic receptors.

Applications Tirofiban intermediate.

Applications Tienilic Acid is a heterocyclic derivative of phenoxyacetic acid. Tienilic acid is used as diuretic, uricosuric, antihypertensive. References Kerremans, A.L., et al.: Eur. J. Clin. Pharmacol., 22, 515 (1982), Manier, J.W., et al.: Am. J. Gastroenterol., 77, 401 (1982)

Applications A labelled diuretic and antihypertensive. References Wagieh, N., et al.: Drug Test. Anal., 2, 113 (2010), Prado-Prado, F., et al.: Bioorg. Med. Chem., 18, 2225 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),

Impurity Verapamil EP Impurity J HCl Applications Nor Verapamil Hydrochloride (Verapamil EP Impurity J HCl) is a metabolite of Verapamil. References Mutlib, A.E., et al.: The Journal of Pharm. & Exp. Therapeutics, 252, 2, 593 (1989)

Impurity Rosuvastatin EP Impurity C (Calcium Salt) Stability Hygroscopic Applications 5-Oxo Rosuvastatin (Rosuvastatin EP Impurity C (Calcium Salt)) is a Rosuvastatin (R700500) impurity. References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Beck, G., et al.: J. Med. Chem., 33, 52 (1990), Koga, T., et al.: Lipids, 30, 775 (1995),

Applications Coumarin anticoagulant. Marketed as the racemate; the S-(-)-form is the more potent isomer. Anticoagulant. This compound is a contaminant of emerging concern (CECs). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Sulfonamides, nesoi

Applications 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid is a potential metabolite of Chlorthalidone. References Salado C., et al.: J. Chromatography. Biomed. App., 690, 195 (1997);

Applications 2-Azidoethanol is used as a reagent in the glycosylation of mono- or polysaccharides. 2-Azidoethanol is also used as a 2’-deoxy-ethynyluridine (EdU) blocker in nuclear DNA, preventing cross reactivity with other antibodies in order to better study its related pathways in the body. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Liboska, R., et al.: PLOS ONE, 7, e51679 (2012); Sun, X., et al.: Biomacromolecules, 3, 1065 (2002)